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The map label for this gene is envZ [H]

Identifier: 209549643

GI number: 209549643

Start: 2112744

End: 2114063

Strand: Reverse

Name: envZ [H]

Synonym: Rleg2_2050

Alternate gene names: 209549643

Gene position: 2114063-2112744 (Counterclockwise)

Preceding gene: 209549644

Following gene: 209549642

Centisome position: 46.59

GC content: 62.95

Gene sequence:

>1320_bases
ATGAGGGCGATCCCCTGGTTCTCGGGTTTGATGTGGCCGAGGACGTTGCGGTCGCGGATCTTCCTCATCCTGCTCATCGG
TCTCGCCCTTGCCTACGGGCTGTCCTTCAGTGTGCTCTATATGGAGCGCACCATGTCGGCCAAGGCGGTGATGCTCGGCA
CGCTGGAGAATGACGTCGCAACGTCGATCGCCGTTCTCGACCGGCTTCCACCAGGCGAGCGCGGCGTTCTCCTCGACCGG
CTGAGCCGCGGCAATTACCGTTTCCTGCTCGGGACCGGCCTTCCAGGCGTGCCCGACACGTCAAGCAAGGGGGCGGAGAT
ATCAGGCAAGATCGAGGAGGCGATCGGACATCGCTTTCCGATCAGCATCGAACGGATTCCAGGTGAGGTGAACCGATTGC
AGGCGCATCTGACGCTGAGCGATGGAAGCCCGCTGACGATCGACGTCACGCCGAAGGGCGTCATGCCGATCGCCGCATGG
CTGCCCTATGTCTTCGTCATCCAGATGCTGCTGCTCATCCTCTGCACCTGGTTTGCGGTTCGCCAGGCGATCCGGCCGCT
CGGTGCGCTTGCTGCCGCCGCCGATGCGCTCGATCCGAACAAGGATGGTCCCGCTTTGAGCGAGGCCGGTCCGAGCGAGG
TCGCGCATGCGGTGAGGGCATTCAATGCGATGCGGGAGCGGATCGCCCATTACCTCGAAGAGCGTGTACAGATACTGGCG
GCCATCTCGCACGATCTGCAGACGCCGATCACCCGCATGCGGCTGCGCGCCGATATGGCGGAGGACTCGCCTGAAAAGGA
CAAGCTGGTGCATGATCTCGGGGAGATCCAGCGCCTCGTCCAGGACGGTATAGCCTATGCGCGCAGCGCCCACGGCAGCG
GCGAGAAGAATGCCCGCATCGATCTCGCCTCATTCATCGACAGCATATCCTACGACTATCAGGACACCGGAAAGGCGGTG
ACGGTCGTCGGGCTGGTTCAGGGCGCCGCCATGACCAAGCCGCATGCGCTTCGCCGCATTCTCTCGAACTTCATCGACAA
TGCGTTGAAGTTTGCGGGTGCCGCCGAAATCAGCGTCGAGCACAATGCGGAAAACAATGTCGTCATCACCGTGATGGATC
GGGGGCCTGGTATCCCTGACGATATGCTCGAAGCCGCCATGCAGCCCTTCTTCCGGCTGGAGCAATCCCGCAACCGTGAG
ACCGGCGGCACCGGTCTTGGTCTTGCGATCGCCCAGCAGCTGACGGCCAAGATCGGCGGTTCGCTCCGGCTCTACAATCG
CGCCGGTGGCGGGCTGGCGGCGGAAGTCACCCTTCGGTGA

Upstream 100 bases:

>100_bases
AGCGGCTGGGAGACGATGCGCGCGAACCGACCTACATCAAGACGGTGCGCAGTGAAGGCTATGTATTTTCCGTTCCGGTC
GAAATCATGGAGCTGCGCCA

Downstream 100 bases:

>100_bases
CGATGAGGATCGCTGGAATATTTCCGGCGGTTTGTATGGGACAGTGTCCTGGATGCCGGATGCTACGTTTTGTGACATTT
CGGCCGATTTCGGAAACATG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MRAIPWFSGLMWPRTLRSRIFLILLIGLALAYGLSFSVLYMERTMSAKAVMLGTLENDVATSIAVLDRLPPGERGVLLDR
LSRGNYRFLLGTGLPGVPDTSSKGAEISGKIEEAIGHRFPISIERIPGEVNRLQAHLTLSDGSPLTIDVTPKGVMPIAAW
LPYVFVIQMLLLILCTWFAVRQAIRPLGALAAAADALDPNKDGPALSEAGPSEVAHAVRAFNAMRERIAHYLEERVQILA
AISHDLQTPITRMRLRADMAEDSPEKDKLVHDLGEIQRLVQDGIAYARSAHGSGEKNARIDLASFIDSISYDYQDTGKAV
TVVGLVQGAAMTKPHALRRILSNFIDNALKFAGAAEISVEHNAENNVVITVMDRGPGIPDDMLEAAMQPFFRLEQSRNRE
TGGTGLGLAIAQQLTAKIGGSLRLYNRAGGGLAAEVTLR

Sequences:

>Translated_439_residues
MRAIPWFSGLMWPRTLRSRIFLILLIGLALAYGLSFSVLYMERTMSAKAVMLGTLENDVATSIAVLDRLPPGERGVLLDR
LSRGNYRFLLGTGLPGVPDTSSKGAEISGKIEEAIGHRFPISIERIPGEVNRLQAHLTLSDGSPLTIDVTPKGVMPIAAW
LPYVFVIQMLLLILCTWFAVRQAIRPLGALAAAADALDPNKDGPALSEAGPSEVAHAVRAFNAMRERIAHYLEERVQILA
AISHDLQTPITRMRLRADMAEDSPEKDKLVHDLGEIQRLVQDGIAYARSAHGSGEKNARIDLASFIDSISYDYQDTGKAV
TVVGLVQGAAMTKPHALRRILSNFIDNALKFAGAAEISVEHNAENNVVITVMDRGPGIPDDMLEAAMQPFFRLEQSRNRE
TGGTGLGLAIAQQLTAKIGGSLRLYNRAGGGLAAEVTLR
>Mature_439_residues
MRAIPWFSGLMWPRTLRSRIFLILLIGLALAYGLSFSVLYMERTMSAKAVMLGTLENDVATSIAVLDRLPPGERGVLLDR
LSRGNYRFLLGTGLPGVPDTSSKGAEISGKIEEAIGHRFPISIERIPGEVNRLQAHLTLSDGSPLTIDVTPKGVMPIAAW
LPYVFVIQMLLLILCTWFAVRQAIRPLGALAAAADALDPNKDGPALSEAGPSEVAHAVRAFNAMRERIAHYLEERVQILA
AISHDLQTPITRMRLRADMAEDSPEKDKLVHDLGEIQRLVQDGIAYARSAHGSGEKNARIDLASFIDSISYDYQDTGKAV
TVVGLVQGAAMTKPHALRRILSNFIDNALKFAGAAEISVEHNAENNVVITVMDRGPGIPDDMLEAAMQPFFRLEQSRNRE
TGGTGLGLAIAQQLTAKIGGSLRLYNRAGGGLAAEVTLR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=270, Percent_Identity=31.8518518518519, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787894, Length=218, Percent_Identity=31.1926605504587, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=30.9433962264151, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082128, Length=319, Percent_Identity=24.4514106583072, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790861, Length=269, Percent_Identity=26.7657992565056, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=25.4032258064516, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=30.6382978723404, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=26.7148014440433, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=279, Percent_Identity=24.3727598566308, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=304, Percent_Identity=26.9736842105263, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=299, Percent_Identity=25.752508361204, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=28.9915966386555, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=26.457399103139, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=25.7918552036199, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=315, Percent_Identity=26.3492063492064, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47617; Mature: 47617

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIPWFSGLMWPRTLRSRIFLILLIGLALAYGLSFSVLYMERTMSAKAVMLGTLENDVA
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECHHHHHH
TSIAVLDRLPPGERGVLLDRLSRGNYRFLLGTGLPGVPDTSSKGAEISGKIEEAIGHRFP
HHHHHHHCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCC
ISIERIPGEVNRLQAHLTLSDGSPLTIDVTPKGVMPIAAWLPYVFVIQMLLLILCTWFAV
EEHCCCCCHHHHEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQAIRPLGALAAAADALDPNKDGPALSEAGPSEVAHAVRAFNAMRERIAHYLEERVQILA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISHDLQTPITRMRLRADMAEDSPEKDKLVHDLGEIQRLVQDGIAYARSAHGSGEKNARI
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
DLASFIDSISYDYQDTGKAVTVVGLVQGAAMTKPHALRRILSNFIDNALKFAGAAEISVE
HHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
HNAENNVVITVMDRGPGIPDDMLEAAMQPFFRLEQSRNRETGGTGLGLAIAQQLTAKIGG
ECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
SLRLYNRAGGGLAAEVTLR
CEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MRAIPWFSGLMWPRTLRSRIFLILLIGLALAYGLSFSVLYMERTMSAKAVMLGTLENDVA
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECHHHHHH
TSIAVLDRLPPGERGVLLDRLSRGNYRFLLGTGLPGVPDTSSKGAEISGKIEEAIGHRFP
HHHHHHHCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCC
ISIERIPGEVNRLQAHLTLSDGSPLTIDVTPKGVMPIAAWLPYVFVIQMLLLILCTWFAV
EEHCCCCCHHHHEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQAIRPLGALAAAADALDPNKDGPALSEAGPSEVAHAVRAFNAMRERIAHYLEERVQILA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISHDLQTPITRMRLRADMAEDSPEKDKLVHDLGEIQRLVQDGIAYARSAHGSGEKNARI
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
DLASFIDSISYDYQDTGKAVTVVGLVQGAAMTKPHALRRILSNFIDNALKFAGAAEISVE
HHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
HNAENNVVITVMDRGPGIPDDMLEAAMQPFFRLEQSRNRETGGTGLGLAIAQQLTAKIGG
ECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
SLRLYNRAGGGLAAEVTLR
CEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]