Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 209549618

GI number: 209549618

Start: 2086220

End: 2087266

Strand: Direct

Name: moaA [H]

Synonym: Rleg2_2025

Alternate gene names: 209549618

Gene position: 2086220-2087266 (Clockwise)

Preceding gene: 209549615

Following gene: 209549620

Centisome position: 45.97

GC content: 61.8

Gene sequence:

>1047_bases
GTGAATACGAGAGTCGGAACGATAGGCAACGCATCGCTGCTCACGGCGGATGCACATCCGATGATTGACCCTTTCGGCCG
GGCAGTCACCTATCTCCGCGTCTCCGTCACCGATCGCTGCGATTTCCGCTGCACCTATTGCATGGCGGAGAATATGACCT
TCCTGCCGAAGAAGGATCTGTTGACGCTGGAGGAACTCGACCGTCTCTGTTCCGCCTTCGTCGCCAAGGGCGTGAAGAAG
ATCCGGCTCACCGGCGGCGAACCCCTGGTGCGCAAGAACATCATGTATCTGGTCCGCCGGCTCGGCGAAAAGATCGGCGC
CGGCCTCGACGAGGTGACGCTGACCACCAATGGCTCGCAGCTCTCCCGCCATGCCGAGGAGCTTTATGATTGCGGCGTGC
GCCGCATCAACGTCTCGCTCGATACGCTCGACCCCGACAAATTCCGCAAGATCACCCGCTGGGGCGATTTTGCCAAGGTG
ATGGAAGGCATCGACGCCGCTCAGAAAGCCGGCATCAAGATCAAGCTCAACGCCGTGGCGCTCAAGGATTTCAACGACGC
CGAGATGCCCGAAATCATGCGTTTCGCCCATGGTCGCGGCATGGATCTCACCGTCATCGAAACCATGCCGATGGGCGAGA
TCGACGAGGACCGCACCGACCAGTACCTGCCGCTCTCCAAATTGCGGGCGGATCTGGAAAAGCAGTTCACGCTCACCGAT
ATCGACTACCAGACCGGCGGCCCGGCCCGTTATGTCAGGGTAGCTGAAACCGGCGGCCGCCTCGGCTTCATCACGCCGAT
GACCCATAATTTCTGCGAGAGCTGCAACCGCGTCCGCCTCACCTGCACCGGCACGCTCTATATGTGCCTCGGCCAGAACG
ACGCCGCCGATCTGCGCGCCGCACTGCGCGCCACCGAAGACGACGCCCTCCTCCACGCCGCCATCGACGAAGCCATCACC
CGCAAACCGAAGGGCCACGACTTCATCATCGACCGCACGCATAACAGGCCGGCGGTGGCGCGGCATATGAGTGTCACGGG
TGGGTGA

Upstream 100 bases:

>100_bases
CCTTGACGGCGCAATCACATATGCACACATAGAAAGATATCGCTTGAAAACAGGCAGGCATCAGGTCTGGCGCGCTTCAG
ATCCGCCCGCGGAGGAATTG

Downstream 100 bases:

>100_bases
GACGCGGTCCCGCAAAGCGGGAGCGATCGATCCAGTGAATCGATCGCAGCGTCGAACGCCCTGAGCCCAAGCGAAGGGCC
GGGATACAGTGCGGCAGGCT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNTRVGTIGNASLLTADAHPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAENMTFLPKKDLLTLEELDRLCSAFVAKGVKK
IRLTGGEPLVRKNIMYLVRRLGEKIGAGLDEVTLTTNGSQLSRHAEELYDCGVRRINVSLDTLDPDKFRKITRWGDFAKV
MEGIDAAQKAGIKIKLNAVALKDFNDAEMPEIMRFAHGRGMDLTVIETMPMGEIDEDRTDQYLPLSKLRADLEKQFTLTD
IDYQTGGPARYVRVAETGGRLGFITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRAALRATEDDALLHAAIDEAIT
RKPKGHDFIIDRTHNRPAVARHMSVTGG

Sequences:

>Translated_348_residues
MNTRVGTIGNASLLTADAHPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAENMTFLPKKDLLTLEELDRLCSAFVAKGVKK
IRLTGGEPLVRKNIMYLVRRLGEKIGAGLDEVTLTTNGSQLSRHAEELYDCGVRRINVSLDTLDPDKFRKITRWGDFAKV
MEGIDAAQKAGIKIKLNAVALKDFNDAEMPEIMRFAHGRGMDLTVIETMPMGEIDEDRTDQYLPLSKLRADLEKQFTLTD
IDYQTGGPARYVRVAETGGRLGFITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRAALRATEDDALLHAAIDEAIT
RKPKGHDFIIDRTHNRPAVARHMSVTGG
>Mature_348_residues
MNTRVGTIGNASLLTADAHPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAENMTFLPKKDLLTLEELDRLCSAFVAKGVKK
IRLTGGEPLVRKNIMYLVRRLGEKIGAGLDEVTLTTNGSQLSRHAEELYDCGVRRINVSLDTLDPDKFRKITRWGDFAKV
MEGIDAAQKAGIKIKLNAVALKDFNDAEMPEIMRFAHGRGMDLTVIETMPMGEIDEDRTDQYLPLSKLRADLEKQFTLTD
IDYQTGGPARYVRVAETGGRLGFITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRAALRATEDDALLHAAIDEAIT
RKPKGHDFIIDRTHNRPAVARHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=324, Percent_Identity=36.4197530864198, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI22027536, Length=324, Percent_Identity=36.4197530864198, Blast_Score=201, Evalue=6e-52,
Organism=Escherichia coli, GI1786999, Length=334, Percent_Identity=33.2335329341317, Blast_Score=191, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=331, Percent_Identity=37.4622356495468, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=334, Percent_Identity=38.3233532934132, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=337, Percent_Identity=37.9821958456973, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28574488, Length=327, Percent_Identity=38.5321100917431, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI28574490, Length=321, Percent_Identity=38.9408099688474, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38780; Mature: 38780

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRVGTIGNASLLTADAHPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAENMTFLPKKDL
CCCCCCCCCCCEEEEECCCCCCCHHHHEEEEEEEEECCCCCCEEEEEEECCCEECCCCCC
LTLEELDRLCSAFVAKGVKKIRLTGGEPLVRKNIMYLVRRLGEKIGAGLDEVTLTTNGSQ
CCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHH
LSRHAEELYDCGVRRINVSLDTLDPDKFRKITRWGDFAKVMEGIDAAQKAGIKIKLNAVA
HHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEE
LKDFNDAEMPEIMRFAHGRGMDLTVIETMPMGEIDEDRTDQYLPLSKLRADLEKQFTLTD
EECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEE
IDYQTGGPARYVRVAETGGRLGFITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRA
CCCCCCCCEEEEEEEECCCCEEEECCCHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHH
ALRATEDDALLHAAIDEAITRKPKGHDFIIDRTHNRPAVARHMSVTGG
HHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHEEECCCC
>Mature Secondary Structure
MNTRVGTIGNASLLTADAHPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAENMTFLPKKDL
CCCCCCCCCCCEEEEECCCCCCCHHHHEEEEEEEEECCCCCCEEEEEEECCCEECCCCCC
LTLEELDRLCSAFVAKGVKKIRLTGGEPLVRKNIMYLVRRLGEKIGAGLDEVTLTTNGSQ
CCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHH
LSRHAEELYDCGVRRINVSLDTLDPDKFRKITRWGDFAKVMEGIDAAQKAGIKIKLNAVA
HHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEE
LKDFNDAEMPEIMRFAHGRGMDLTVIETMPMGEIDEDRTDQYLPLSKLRADLEKQFTLTD
EECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEE
IDYQTGGPARYVRVAETGGRLGFITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRA
CCCCCCCCEEEEEEEECCCCEEEECCCHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHH
ALRATEDDALLHAAIDEAITRKPKGHDFIIDRTHNRPAVARHMSVTGG
HHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA