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The map label for this gene is fumC [H]

Identifier: 209549609

GI number: 209549609

Start: 2076690

End: 2078081

Strand: Direct

Name: fumC [H]

Synonym: Rleg2_2016

Alternate gene names: 209549609

Gene position: 2076690-2078081 (Clockwise)

Preceding gene: 209549607

Following gene: 209549611

Centisome position: 45.76

GC content: 62.5

Gene sequence:

>1392_bases
ATGACCGCAACCCGAACCGAAACCGATACTTTTGGCCCGATCGACGTCACCGCCGACCGATATTGGGGCGCCCAGGCCGA
GCGTTCGCTCGGCAATTTCAAGATCGGCTGGGAAAAGCAGCCGCTGTCGATCGTGCGTGCGCTCGGCATCGTCAAACAGG
CGGCCGCCCGCGCCAACATGTCGCTCGGCCAACTCGACCCCGCGCTTGGCCAAGCCATCGTCGATGCCGCCCAGGAAGTG
ATCGACGGCAAACTCGACGAGCATTTTCCGCTTGTCGTCTGGCAGACCGGTTCGGGGACGCAGTCCAACATGAATGCCAA
TGAGGTGATCTCCAATCGTGCCATAGAAATGCTTGGCGGCGTCATGGGTTCCAAGAAGCCGGTGCATCCGAACGATCACG
TCAATATGAGCCAGTCGTCGAACGACACCTACCCGACGGCGATGCATATCGCCTGCGCCGAACGGATCGCCCATCACCTG
CTGCCATCCCTGAAGCACCTGCATGCCGCCCTCGACATGAAGGTCACCGAATTCAGCCACATCATCAAGATCGGCCGCAC
CCACACCCAGGATGCCACACCGCTGACGCTCGGCCAGGAATTTTCGGGTTATGCCGCCCAGGTCGGCTCCGCCATCAAGC
GCATCGAAATGACCCTGCCCGGCCTCTGCGAACTCGCCCAGGGCGGCACCGCCGTCGGCACCGGCCTCAATGCGCCTATC
GGTTTCGCCGAGAAGGTCGCTGAAGAAATCGCCGCCATTACCCAAATGCCCTTCGTGACCGCGCCGAACAAGTTCGAGGC
GCTTGCCTCGCATGACAGCATGGTCTTTTCCCATGGCGCCATCAATGCGGCGGCTGCCGCCCTCTTCAAGATCGCCAACG
ACATCCGCCTGCTCGGCTCCGGCCCGCGCGCCGGTCTCGGCGAACTGGCGCTGCCGGAAAACGAGCCCGGCTCCTCGATC
ATGCCCGGCAAGGTCAACCCGACCCAGTGCGAGGCGCTGACCCAGGTCTGCATCCACATCTTCGGCAATCACGCCGCGCT
GACCTTCGCCGACAGCCAGGGCCATTTCGAACTCAACGTCTACAATCCGATGATGGCCTATAATTTCCTGCAGTCGGTGC
AGCTGCTGGCCGACGCCGCCGTCTCCTTCACCGACAATTGCGTCGTCGGCATCGAGGCACGCGAAGACAACATCAAGGCC
GGCCTCGACCGCTCGCTGATGCTGGTGACCGCCCTTGCCCCGAAGATCGGCTACGACGCAGCCGCCAAGATCGCCAAGAC
CGCCCACAAGAACGGCACGACGCTGAAGGAAGAGGCGCTTGCGAGTGGACTGGTCTCGGCGGAGGATTACGATGCGATCG
TCCGCCCGGAAACGATGATCGGCCCGAAATAA

Upstream 100 bases:

>100_bases
ATTTCGCATAGGCTCCGGTTTTCTTGTCGGGCGTTCCCACCTATAAGACCTCATCTTGCTCGGATGACCGAAAACAGCAT
GTAAAGGGAAGGCAAGGCCG

Downstream 100 bases:

>100_bases
AAGACGAGGGGCTGCCCCTCATCCGGCTGCCGCCACCTTCTCCCCGTAAAAACGGGGCGAAGGGGACACGCCGCGCCCCC
ATCTGTCCCCCGCCCACTTC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTATRTETDTFGPIDVTADRYWGAQAERSLGNFKIGWEKQPLSIVRALGIVKQAAARANMSLGQLDPALGQAIVDAAQEV
IDGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERIAHHL
LPSLKHLHAALDMKVTEFSHIIKIGRTHTQDATPLTLGQEFSGYAAQVGSAIKRIEMTLPGLCELAQGGTAVGTGLNAPI
GFAEKVAEEIAAITQMPFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRLLGSGPRAGLGELALPENEPGSSI
MPGKVNPTQCEALTQVCIHIFGNHAALTFADSQGHFELNVYNPMMAYNFLQSVQLLADAAVSFTDNCVVGIEAREDNIKA
GLDRSLMLVTALAPKIGYDAAAKIAKTAHKNGTTLKEEALASGLVSAEDYDAIVRPETMIGPK

Sequences:

>Translated_463_residues
MTATRTETDTFGPIDVTADRYWGAQAERSLGNFKIGWEKQPLSIVRALGIVKQAAARANMSLGQLDPALGQAIVDAAQEV
IDGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERIAHHL
LPSLKHLHAALDMKVTEFSHIIKIGRTHTQDATPLTLGQEFSGYAAQVGSAIKRIEMTLPGLCELAQGGTAVGTGLNAPI
GFAEKVAEEIAAITQMPFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRLLGSGPRAGLGELALPENEPGSSI
MPGKVNPTQCEALTQVCIHIFGNHAALTFADSQGHFELNVYNPMMAYNFLQSVQLLADAAVSFTDNCVVGIEAREDNIKA
GLDRSLMLVTALAPKIGYDAAAKIAKTAHKNGTTLKEEALASGLVSAEDYDAIVRPETMIGPK
>Mature_462_residues
TATRTETDTFGPIDVTADRYWGAQAERSLGNFKIGWEKQPLSIVRALGIVKQAAARANMSLGQLDPALGQAIVDAAQEVI
DGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERIAHHLL
PSLKHLHAALDMKVTEFSHIIKIGRTHTQDATPLTLGQEFSGYAAQVGSAIKRIEMTLPGLCELAQGGTAVGTGLNAPIG
FAEKVAEEIAAITQMPFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRLLGSGPRAGLGELALPENEPGSSIM
PGKVNPTQCEALTQVCIHIFGNHAALTFADSQGHFELNVYNPMMAYNFLQSVQLLADAAVSFTDNCVVGIEAREDNIKAG
LDRSLMLVTALAPKIGYDAAAKIAKTAHKNGTTLKEEALASGLVSAEDYDAIVRPETMIGPK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=65.7266811279826, Blast_Score=601, Evalue=1e-172,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=57.7006507592191, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=37.7440347071584, Blast_Score=312, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=64.7311827956989, Blast_Score=615, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=64.3292682926829, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=63.3620689655172, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=62.987012987013, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=62.987012987013, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=60.2591792656587, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=59.3952483801296, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=50.8620689655172, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49181; Mature: 49049

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRTETDTFGPIDVTADRYWGAQAERSLGNFKIGWEKQPLSIVRALGIVKQAAARANM
CCCCCCCCCCCCCCEECCCHHCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCC
SLGQLDPALGQAIVDAAQEVIDGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
CHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
VMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERIAHHLLPSLKHLHAALDMKVTEFSH
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IIKIGRTHTQDATPLTLGQEFSGYAAQVGSAIKRIEMTLPGLCELAQGGTAVGTGLNAPI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEECCCCCCCC
GFAEKVAEEIAAITQMPFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRLLGS
CHHHHHHHHHHHHHHCCCEECCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHEEECC
GPRAGLGELALPENEPGSSIMPGKVNPTQCEALTQVCIHIFGNHAALTFADSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEE
YNPMMAYNFLQSVQLLADAAVSFTDNCVVGIEAREDNIKAGLDRSLMLVTALAPKIGYDA
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCCHHHHHHHHHHCCCCHHH
AAKIAKTAHKNGTTLKEEALASGLVSAEDYDAIVRPETMIGPK
HHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure 
TATRTETDTFGPIDVTADRYWGAQAERSLGNFKIGWEKQPLSIVRALGIVKQAAARANM
CCCCCCCCCCCCCEECCCHHCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCC
SLGQLDPALGQAIVDAAQEVIDGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
CHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
VMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERIAHHLLPSLKHLHAALDMKVTEFSH
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IIKIGRTHTQDATPLTLGQEFSGYAAQVGSAIKRIEMTLPGLCELAQGGTAVGTGLNAPI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEECCCCCCCC
GFAEKVAEEIAAITQMPFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRLLGS
CHHHHHHHHHHHHHHCCCEECCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHEEECC
GPRAGLGELALPENEPGSSIMPGKVNPTQCEALTQVCIHIFGNHAALTFADSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEE
YNPMMAYNFLQSVQLLADAAVSFTDNCVVGIEAREDNIKAGLDRSLMLVTALAPKIGYDA
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCCHHHHHHHHHHCCCCHHH
AAKIAKTAHKNGTTLKEEALASGLVSAEDYDAIVRPETMIGPK
HHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]