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The map label for this gene is gph [H]

Identifier: 209549607

GI number: 209549607

Start: 2073316

End: 2074026

Strand: Direct

Name: gph [H]

Synonym: Rleg2_2014

Alternate gene names: 209549607

Gene position: 2073316-2074026 (Clockwise)

Preceding gene: 209549603

Following gene: 209549609

Centisome position: 45.69

GC content: 64.42

Gene sequence:

>711_bases
TTGACCCCTTCCCACGCCCGCCCGCCACTCATCGTCTTCGATCTCGACGGCACCCTTCTCGATACCCATACGGATCTGGT
CGAGAGCCTCAATCATACGATCGCAGCCCTTGGCCTCGACCCGGTCAGCTATGACGACCTTACCCATCTCGTCGGCCACG
GCGCGCGCGTGATGATCGAGCGCGCCTGCCGCCTGCGCGGCCATCCGCTCGAAAGCGACGCCCTGCCGGCGCTCGTCGAG
CGCTTTGTCGCCCATTATGCCGGCAACATGCCCGGCCGTACCGAACCCTATCCCGGCCTCGTCGCCGCGATGGACCGGCT
TAAATCTGCCCGTTACCGCCTCGCCGTCTGCACCAACAAGATGGAAAGCCTGGCGCTCGGCCTGCTCGAGAAGCTCGACC
TCGTCCGCTATTTCGACGCCATCACCGGCGGCGACAGCTTCACCGTGCGCAAGCCCGACGCCCGCCACCTCACCGGCACC
ATCGAACGCGCCGGCGGCGACATCACCCGCAGCGTCATGATCGGCGACAGCATCAACGATATCGCCGTGGCCAGGAATGC
CGGCGTGCCGTCGATCGCCGTACCCTTCGGCTATTCCGACGTGCCGGTCTCCAACCTGGATCCGGATATGATCATCACCC
ATTACGATGAACTGACGCCGGAACTGGTGGAGCGTCTGTTACGGGAATATGCGGTGAAGGTCGCGGTCTGA

Upstream 100 bases:

>100_bases
ACCGTTCCGGGGGCGACCTGTCGTTCCCAGGGGAAACCTGTCGTGCCTCAGGACGACTTGTCGCTCTCCAGAATGGCCCA
TTGCGCAAAGAGACAAACCC

Downstream 100 bases:

>100_bases
GGCTGCAGGCCGCATCGTCCTCCTTCGCCATTCCTTTGCCGGCGTACCGTGTGAGCCCCCCTCTGCCCTGCCGGGCATCT
CCCCCCAGGTGGGGAGATTG

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTPSHARPPLIVFDLDGTLLDTHTDLVESLNHTIAALGLDPVSYDDLTHLVGHGARVMIERACRLRGHPLESDALPALVE
RFVAHYAGNMPGRTEPYPGLVAAMDRLKSARYRLAVCTNKMESLALGLLEKLDLVRYFDAITGGDSFTVRKPDARHLTGT
IERAGGDITRSVMIGDSINDIAVARNAGVPSIAVPFGYSDVPVSNLDPDMIITHYDELTPELVERLLREYAVKVAV

Sequences:

>Translated_236_residues
MTPSHARPPLIVFDLDGTLLDTHTDLVESLNHTIAALGLDPVSYDDLTHLVGHGARVMIERACRLRGHPLESDALPALVE
RFVAHYAGNMPGRTEPYPGLVAAMDRLKSARYRLAVCTNKMESLALGLLEKLDLVRYFDAITGGDSFTVRKPDARHLTGT
IERAGGDITRSVMIGDSINDIAVARNAGVPSIAVPFGYSDVPVSNLDPDMIITHYDELTPELVERLLREYAVKVAV
>Mature_235_residues
TPSHARPPLIVFDLDGTLLDTHTDLVESLNHTIAALGLDPVSYDDLTHLVGHGARVMIERACRLRGHPLESDALPALVER
FVAHYAGNMPGRTEPYPGLVAAMDRLKSARYRLAVCTNKMESLALGLLEKLDLVRYFDAITGGDSFTVRKPDARHLTGTI
ERAGGDITRSVMIGDSINDIAVARNAGVPSIAVPFGYSDVPVSNLDPDMIITHYDELTPELVERLLREYAVKVAV

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=230, Percent_Identity=30, Blast_Score=98, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983424, Length=252, Percent_Identity=27.3809523809524, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 25751; Mature: 25620

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSHARPPLIVFDLDGTLLDTHTDLVESLNHTIAALGLDPVSYDDLTHLVGHGARVMIE
CCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
RACRLRGHPLESDALPALVERFVAHYAGNMPGRTEPYPGLVAAMDRLKSARYRLAVCTNK
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MESLALGLLEKLDLVRYFDAITGGDSFTVRKPDARHLTGTIERAGGDITRSVMIGDSIND
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCH
IAVARNAGVPSIAVPFGYSDVPVSNLDPDMIITHYDELTPELVERLLREYAVKVAV
HHEECCCCCCEEEECCCCCCCCCCCCCCCCEEECHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPSHARPPLIVFDLDGTLLDTHTDLVESLNHTIAALGLDPVSYDDLTHLVGHGARVMIE
CCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
RACRLRGHPLESDALPALVERFVAHYAGNMPGRTEPYPGLVAAMDRLKSARYRLAVCTNK
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MESLALGLLEKLDLVRYFDAITGGDSFTVRKPDARHLTGTIERAGGDITRSVMIGDSIND
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCH
IAVARNAGVPSIAVPFGYSDVPVSNLDPDMIITHYDELTPELVERLLREYAVKVAV
HHEECCCCCCEEEECCCCCCCCCCCCCCCCEEECHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]