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The map label for this gene is glmU [H]

Identifier: 209549321

GI number: 209549321

Start: 1761486

End: 1762847

Strand: Direct

Name: glmU [H]

Synonym: Rleg2_1725

Alternate gene names: 209549321

Gene position: 1761486-1762847 (Clockwise)

Preceding gene: 209549320

Following gene: 209549322

Centisome position: 38.82

GC content: 65.35

Gene sequence:

>1362_bases
ATGGAACGTACTTGTCTTGCCGTCATCCTTGCCGCCGGTGACAGCACGCGGATGAAATCCTCGAAATCGAAGGTGCTGCA
TCCGGTCGCCGGCCGGCCGATGATCGCCCATGTGGTCGAGGCGGTCGCTTCCGCCGGCATCTCCTCCGTCGCACTCGTCG
TCGGCCGCGATGCCGAGGAAGTGGCAAAGGCCGCAAGCATCGCCGGCGTCGGCATCGAAGCCTGCCTGCAGAAAGAGCGC
CTCGGCACTGGCCATGCAGTACTGGCGGCGCGCGAAGCGATCGCCAAGGGCTATGACGATATTCTCGTCACCTATGGCGA
TGTGCCGCTGCAGACCGACGGGCCGCTGAAGGCTGCTCGTCAGGGCCTTGCCGATGGCAGCGATATCGTCGTCATCGGCT
TCCACACCGATCGCCCGACCGGTTACGGCCGCCTGCTCGTCAAGGACGGCGAACTCATCGCCATCCGCGAGGAAAAGGAC
GCGACCGATGCCGAGCGCACCGTCACCTGGTGCAACAGCGGGCTGATGGCGATCAACGGCCGCAAGGCGCTCGATCTTCT
CCAGCGCATCGGCAACGCCAATGCCAAGGGCGAATTCTATCTGACCGATCTCGTCGAGATCGCCCGCTCGCTCGGCGGCC
GCGTCACCGCCGTCGATGCGCCTGAAATCGAGATGACCGGCTGCAACACCCGGGCCGAACTTGCCGTCATCGAGCGTTTC
TGGCAGGAGCGCCGCCGCCACCAGCTGATGCTTTCAGGCGTCACCATGATCGCGCCGGAAACGGTCTTTCTGTCCTACGA
CACGGTCATCGGCCAGGATGCGCTGATCGAGCCGAACGTCGTTTTCGGTCCGGGCGCGGTGATCGACAGCGGCGCCGTCA
TTCACGCCTTCTCGCATATCGAAGGCGCCCATGTCAGCCAGGGCGCGACCGTCGGACCCTTCGCGCGGCTGCGGCCGGGT
GCGGATCTCGGCAATGGTTCGAAGGTCGGCAATTTCTGCGAGGTCAAGAACGGGCGGATCGGCGAGGGCGCCAAGGTCAA
CCATCTCACCTATATCGGCGATGCCGTCATCGGCGCCGGCAGCAATATCGGCGCCGGCACGATCACCTGCAATTATGACG
GCGTCAACAAGAGCGAGACGGTGATCGGCGAAAACGCCTTCATCGGTTCGAACTCCTCGCTGGTCGCGCCGGTGACGATC
GGCGATGGCGCCTATATCGCCTCCGGCAGCGTCATCACCGCCGACGTGCCGGCCGATGCGCTGGCGCTCGGCCGTGCCCG
GCAGGAGATCAAGCCCGGCCGCGCCTCTCTGCTGCGCGAGCGCGCGCTCGCCACCAAGGCGGCGAAGAAGGCAAAGGGCT
GA

Upstream 100 bases:

>100_bases
AATCCGCGCCGCGTGCTTTCCGAAAATCGATTCCGATTTCAGGAATTATGCAGTATGAGGCAACAAAGCCGCCTCATGGC
GCGGATTCGCGGAGCAGATC

Downstream 100 bases:

>100_bases
TCCGTCTTGCGTAACCGGCGGAAATTCAAAGTGACCGCCGAGGTGATTGATAACTAAGCAGGAATCGTTAGGACTGGCCC
CGTTGTCGGAGCCAAAAGCA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MERTCLAVILAAGDSTRMKSSKSKVLHPVAGRPMIAHVVEAVASAGISSVALVVGRDAEEVAKAASIAGVGIEACLQKER
LGTGHAVLAAREAIAKGYDDILVTYGDVPLQTDGPLKAARQGLADGSDIVVIGFHTDRPTGYGRLLVKDGELIAIREEKD
ATDAERTVTWCNSGLMAINGRKALDLLQRIGNANAKGEFYLTDLVEIARSLGGRVTAVDAPEIEMTGCNTRAELAVIERF
WQERRRHQLMLSGVTMIAPETVFLSYDTVIGQDALIEPNVVFGPGAVIDSGAVIHAFSHIEGAHVSQGATVGPFARLRPG
ADLGNGSKVGNFCEVKNGRIGEGAKVNHLTYIGDAVIGAGSNIGAGTITCNYDGVNKSETVIGENAFIGSNSSLVAPVTI
GDGAYIASGSVITADVPADALALGRARQEIKPGRASLLRERALATKAAKKAKG

Sequences:

>Translated_453_residues
MERTCLAVILAAGDSTRMKSSKSKVLHPVAGRPMIAHVVEAVASAGISSVALVVGRDAEEVAKAASIAGVGIEACLQKER
LGTGHAVLAAREAIAKGYDDILVTYGDVPLQTDGPLKAARQGLADGSDIVVIGFHTDRPTGYGRLLVKDGELIAIREEKD
ATDAERTVTWCNSGLMAINGRKALDLLQRIGNANAKGEFYLTDLVEIARSLGGRVTAVDAPEIEMTGCNTRAELAVIERF
WQERRRHQLMLSGVTMIAPETVFLSYDTVIGQDALIEPNVVFGPGAVIDSGAVIHAFSHIEGAHVSQGATVGPFARLRPG
ADLGNGSKVGNFCEVKNGRIGEGAKVNHLTYIGDAVIGAGSNIGAGTITCNYDGVNKSETVIGENAFIGSNSSLVAPVTI
GDGAYIASGSVITADVPADALALGRARQEIKPGRASLLRERALATKAAKKAKG
>Mature_453_residues
MERTCLAVILAAGDSTRMKSSKSKVLHPVAGRPMIAHVVEAVASAGISSVALVVGRDAEEVAKAASIAGVGIEACLQKER
LGTGHAVLAAREAIAKGYDDILVTYGDVPLQTDGPLKAARQGLADGSDIVVIGFHTDRPTGYGRLLVKDGELIAIREEKD
ATDAERTVTWCNSGLMAINGRKALDLLQRIGNANAKGEFYLTDLVEIARSLGGRVTAVDAPEIEMTGCNTRAELAVIERF
WQERRRHQLMLSGVTMIAPETVFLSYDTVIGQDALIEPNVVFGPGAVIDSGAVIHAFSHIEGAHVSQGATVGPFARLRPG
ADLGNGSKVGNFCEVKNGRIGEGAKVNHLTYIGDAVIGAGSNIGAGTITCNYDGVNKSETVIGENAFIGSNSSLVAPVTI
GDGAYIASGSVITADVPADALALGRARQEIKPGRASLLRERALATKAAKKAKG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=444, Percent_Identity=41.4414414414414, Blast_Score=318, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6320148, Length=350, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 47167; Mature: 47167

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTCLAVILAAGDSTRMKSSKSKVLHPVAGRPMIAHVVEAVASAGISSVALVVGRDAEE
CCCCEEEEEEECCCCHHHHCCHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHH
VAKAASIAGVGIEACLQKERLGTGHAVLAAREAIAKGYDDILVTYGDVPLQTDGPLKAAR
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCEECCCCCCHHHHH
QGLADGSDIVVIGFHTDRPTGYGRLLVKDGELIAIREEKDATDAERTVTWCNSGLMAING
HCCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHCCCEEEECC
RKALDLLQRIGNANAKGEFYLTDLVEIARSLGGRVTAVDAPEIEMTGCNTRAELAVIERF
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCEEEEECCCCEEEECCCCHHHHHHHHHH
WQERRRHQLMLSGVTMIAPETVFLSYDTVIGQDALIEPNVVFGPGAVIDSGAVIHAFSHI
HHHHHHHHHHHCCEEEECCCEEEEEECHHCCCCCEECCCEEECCCCEECCCCEEEEEHHC
EGAHVSQGATVGPFARLRPGADLGNGSKVGNFCEVKNGRIGEGAKVNHLTYIGDAVIGAG
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEECCHHEECC
SNIGAGTITCNYDGVNKSETVIGENAFIGSNSSLVAPVTIGDGAYIASGSVITADVPADA
CCCCCCEEEEECCCCCCCCEEECCCEEECCCCCEEEEEEECCCCEEECCCEEEECCCHHH
LALGRARQEIKPGRASLLRERALATKAAKKAKG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERTCLAVILAAGDSTRMKSSKSKVLHPVAGRPMIAHVVEAVASAGISSVALVVGRDAEE
CCCCEEEEEEECCCCHHHHCCHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHH
VAKAASIAGVGIEACLQKERLGTGHAVLAAREAIAKGYDDILVTYGDVPLQTDGPLKAAR
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCEECCCCCCHHHHH
QGLADGSDIVVIGFHTDRPTGYGRLLVKDGELIAIREEKDATDAERTVTWCNSGLMAING
HCCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHCCCEEEECC
RKALDLLQRIGNANAKGEFYLTDLVEIARSLGGRVTAVDAPEIEMTGCNTRAELAVIERF
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCEEEEECCCCEEEECCCCHHHHHHHHHH
WQERRRHQLMLSGVTMIAPETVFLSYDTVIGQDALIEPNVVFGPGAVIDSGAVIHAFSHI
HHHHHHHHHHHCCEEEECCCEEEEEECHHCCCCCEECCCEEECCCCEECCCCEEEEEHHC
EGAHVSQGATVGPFARLRPGADLGNGSKVGNFCEVKNGRIGEGAKVNHLTYIGDAVIGAG
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEECCHHEECC
SNIGAGTITCNYDGVNKSETVIGENAFIGSNSSLVAPVTIGDGAYIASGSVITADVPADA
CCCCCCEEEEECCCCCCCCEEECCCEEECCCCCEEEEEEECCCCEEECCCEEEECCCHHH
LALGRARQEIKPGRASLLRERALATKAAKKAKG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA