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The map label for this gene is lpxB [H]

Identifier: 209549194

GI number: 209549194

Start: 1620241

End: 1621410

Strand: Direct

Name: lpxB [H]

Synonym: Rleg2_1595

Alternate gene names: 209549194

Gene position: 1620241-1621410 (Clockwise)

Preceding gene: 209549193

Following gene: 209549196

Centisome position: 35.7

GC content: 62.74

Gene sequence:

>1170_bases
ATGAACGGGCCGCCGCTGAAGATCGCCGTCATTGCCGGCGAGGTATCGGGTGATCTGCTCGGCGCCGATCTCATCGCCGC
CCTGAAGCGGGTCCACACCGGACCGTTGGAACTTGTCGGCGTCGGCGGCGAGGGGCTGCAGGCCGAGGGCTTGCGATCCC
TGTTCGATTTCTCCGAGCTGTCGATCATGGGCATTACCCAGGTGCTGAGCCGGCTGCCAAAGCTGTATAGCCTGATCCGC
CGGACCACCGCTGCCATCGTCGCTGCAAGGCCTGACATTCTCCTCATTATCGACAGCCCGGATTTCACCCATCGCGTCGC
AAAGCGCGTCCGCACCGCGCTGCCCGATCTGCCTGTCGTCAATTACGTCTGTCCGAGCGTCTGGGCCTGGAAGGAATATC
GCGCCACGCGCATGCTTGCCTATGTCGATCATGTGCTCGCCGTCCTGCCTTTCGAGCCGGCGGCGATGCAGCGCCTTGGC
GGACCGGCTACCACCTATGTCGGCCATCGCCTGACCGCCGACCTCGCGCTCTTGGAGACCCGGCGCCGGCGCGCCGGCAG
GCAGCCCGGCAACGGCCCAATCCTGCTTCTGCCCGGCTCACGCTCCTCCGAAATCCAGAAGCTTCTGCCGCATTTCGAGG
TGGCGGCAAGCGAACTTGTCGCCCGCAATGGGCCGACGCGCTTTGTTCTGCCGACGGTGACGCACAGGCAAGCGCTCGTC
CGCCAATTGACGGCGGAATGGGCGGTCAAGCCGGAAATCGTTGTCGGCGCTGAGGCTAAATGGAAGGCCTTCGCTGAAGC
CGATGCGGCGATGGCTGCATCCGGAACCGTCATTCTTGAACTGGCGCTTGCCGATGTTCCCGTCGTCTCCGCCTACAAGG
TCGACTGGATTATGCGTCTCCTGACGTCAAGCATCAAGACTTGGACTGGCGCACTGCCGAACCTTATCGCCGATTACGCT
CTCGTGCCGGAATATCTGAACGACGTCGTTCGCGGCGCAAGCCTCGCCCGCTGGATGGAAAGGCTGTCGGCCGACACCTA
CCAGCTCAAGGCGATGAAGGAAGGCTATGATCTCATCTGGCAGCGCATGCAGACGGAAAAACCGCCTGGCGAACATGCCG
CCGAAATCCTGCTCGAGGTGCTGAACAAGAAAAAACCCGGTCGTCTCTGA

Upstream 100 bases:

>100_bases
GCTCGCTGGTGCTCGATCGCCCCGCCGTCATCAAGGCCGCCGATGAGGCCGGGCTTTTCGTCTGCGGCATCGATCGCGGG
CTGCCGGCATGGGGGCTCGA

Downstream 100 bases:

>100_bases
CCGGGTTTTCTTCTTCTCTAGCCGATATATTGGCCGAGGCGATCAGCGCTTCGAAACCGGGATGTAGTCGCGCTTCGGTT
CGCCGATATAGAGCTGGCGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNGPPLKIAVIAGEVSGDLLGADLIAALKRVHTGPLELVGVGGEGLQAEGLRSLFDFSELSIMGITQVLSRLPKLYSLIR
RTTAAIVAARPDILLIIDSPDFTHRVAKRVRTALPDLPVVNYVCPSVWAWKEYRATRMLAYVDHVLAVLPFEPAAMQRLG
GPATTYVGHRLTADLALLETRRRRAGRQPGNGPILLLPGSRSSEIQKLLPHFEVAASELVARNGPTRFVLPTVTHRQALV
RQLTAEWAVKPEIVVGAEAKWKAFAEADAAMAASGTVILELALADVPVVSAYKVDWIMRLLTSSIKTWTGALPNLIADYA
LVPEYLNDVVRGASLARWMERLSADTYQLKAMKEGYDLIWQRMQTEKPPGEHAAEILLEVLNKKKPGRL

Sequences:

>Translated_389_residues
MNGPPLKIAVIAGEVSGDLLGADLIAALKRVHTGPLELVGVGGEGLQAEGLRSLFDFSELSIMGITQVLSRLPKLYSLIR
RTTAAIVAARPDILLIIDSPDFTHRVAKRVRTALPDLPVVNYVCPSVWAWKEYRATRMLAYVDHVLAVLPFEPAAMQRLG
GPATTYVGHRLTADLALLETRRRRAGRQPGNGPILLLPGSRSSEIQKLLPHFEVAASELVARNGPTRFVLPTVTHRQALV
RQLTAEWAVKPEIVVGAEAKWKAFAEADAAMAASGTVILELALADVPVVSAYKVDWIMRLLTSSIKTWTGALPNLIADYA
LVPEYLNDVVRGASLARWMERLSADTYQLKAMKEGYDLIWQRMQTEKPPGEHAAEILLEVLNKKKPGRL
>Mature_389_residues
MNGPPLKIAVIAGEVSGDLLGADLIAALKRVHTGPLELVGVGGEGLQAEGLRSLFDFSELSIMGITQVLSRLPKLYSLIR
RTTAAIVAARPDILLIIDSPDFTHRVAKRVRTALPDLPVVNYVCPSVWAWKEYRATRMLAYVDHVLAVLPFEPAAMQRLG
GPATTYVGHRLTADLALLETRRRRAGRQPGNGPILLLPGSRSSEIQKLLPHFEVAASELVARNGPTRFVLPTVTHRQALV
RQLTAEWAVKPEIVVGAEAKWKAFAEADAAMAASGTVILELALADVPVVSAYKVDWIMRLLTSSIKTWTGALPNLIADYA
LVPEYLNDVVRGASLARWMERLSADTYQLKAMKEGYDLIWQRMQTEKPPGEHAAEILLEVLNKKKPGRL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=387, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42616; Mature: 42616

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGPPLKIAVIAGEVSGDLLGADLIAALKRVHTGPLELVGVGGEGLQAEGLRSLFDFSEL
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHH
SIMGITQVLSRLPKLYSLIRRTTAAIVAARPDILLIIDSPDFTHRVAKRVRTALPDLPVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHHHHHHHHHHHCCCCCHH
NYVCPSVWAWKEYRATRMLAYVDHVLAVLPFEPAAMQRLGGPATTYVGHRLTADLALLET
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RRRRAGRQPGNGPILLLPGSRSSEIQKLLPHFEVAASELVARNGPTRFVLPTVTHRQALV
HHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHH
RQLTAEWAVKPEIVVGAEAKWKAFAEADAAMAASGTVILELALADVPVVSAYKVDWIMRL
HHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHH
LTSSIKTWTGALPNLIADYALVPEYLNDVVRGASLARWMERLSADTYQLKAMKEGYDLIW
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QRMQTEKPPGEHAAEILLEVLNKKKPGRL
HHHHCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNGPPLKIAVIAGEVSGDLLGADLIAALKRVHTGPLELVGVGGEGLQAEGLRSLFDFSEL
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHH
SIMGITQVLSRLPKLYSLIRRTTAAIVAARPDILLIIDSPDFTHRVAKRVRTALPDLPVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHHHHHHHHHHHCCCCCHH
NYVCPSVWAWKEYRATRMLAYVDHVLAVLPFEPAAMQRLGGPATTYVGHRLTADLALLET
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RRRRAGRQPGNGPILLLPGSRSSEIQKLLPHFEVAASELVARNGPTRFVLPTVTHRQALV
HHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHH
RQLTAEWAVKPEIVVGAEAKWKAFAEADAAMAASGTVILELALADVPVVSAYKVDWIMRL
HHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHH
LTSSIKTWTGALPNLIADYALVPEYLNDVVRGASLARWMERLSADTYQLKAMKEGYDLIW
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QRMQTEKPPGEHAAEILLEVLNKKKPGRL
HHHHCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA