Click here to switch to the map view.

The map label for this gene is nqo13 [H]

Identifier: 209548876

GI number: 209548876

Start: 1290093

End: 1291604

Strand: Direct

Name: nqo13 [H]

Synonym: Rleg2_1273

Alternate gene names: 209548876

Gene position: 1290093-1291604 (Clockwise)

Preceding gene: 209548875

Following gene: 209548877

Centisome position: 28.43

GC content: 59.92

Gene sequence:

>1512_bases
ATGACCGATTGGCCTATTCTTACAACGGTCACCTTCCTGCCGCTCGTCGGCGTGGTGCTCCTGCTATTGATGAACGGCGA
GAGCGAAACCGGCCGCAAGAACGTGCTGTGGATCTCGCTGATCACCACCGTCTTCACCTTCATCGTCTCGCTCTTCATCT
GGATCGGCTTCGACAATGCCAATCCGGGCTTCCAGATGTTGGAAAAGCATGACTGGCTCGGCACCGGCATCGGCTACCAT
CTCGGCGTCGACGGCATCTCGATGCTGTTCGTCATCCTGTCGACCTTCCTGATGCCCTTCTGCGTGCTGGCGAGCTGGCT
CTCGATCGAGAAGCGCCTGAAGGAATATATGATCGCCTTCCTCATCCTCGAAACGATGATGGTCGGCGTCTTCGTCTCGC
TCGATATCGTGCTCTTCTACGTCTTCTTCGAGGCGGGCCTCATTCCGATGTTCCTGATCATCGGCGTCTGGGGCGGCAAG
GACCGCGTCTACGCGAGCTACAAGTTCTTCCTCTATACGCTGCTCGGTTCGGTGCTGATGCTGCTTGCCATCATGGCGAT
GTACTGGCAGGCCGGCACGACCGATATCACCGCGCTGCTCGCCTACAAGTTCCCGCCGGCGCTGCAGACCTGGTTATGGC
TTGCCTTCTTCGCCTCCTTTGCGGTGAAGATGCCGATGTGGCCGGTTCATACCTGGCTGCCCGACGCCCACGTTCAGGCG
CCGACAGCAGGCTCGGTGATCCTGGCCGGCGTGCTCCTGAAGCTCGGCGGCTACGGTCTGATCCGCTTCTCGCTCGGCAT
GTTCCCGGTCGCATCGGATTATTTCGCACCGTTCGTCTTCGCGCTGTCGGTCATTGCCATCATCTACACCTCGCTGGTGG
CGATGATGCAGGACGATATCAAGAAGCTGATCGCCTATTCCTCCGTGGCGCACATGGGCTATGTCACCATGGGCATTTTC
GCCGCCAACATGCAGGGTGTTCAGGGCTCGATCTTCCAGATGCTCTCGCACGGCATCGTCTCCGGCGCGCTCTTCCTTTG
CGTCGGCGTCGTCTACGACCGCACCCACACCCGCGAGATCAACGCCTATGGCGGCCTCGTCAACAACATGCCGAAATATG
CCGTCGCCATGATGGTCTTCACCATGGCCAATGTCGGGCTTCCCGGCACATCGGGCTTCATCGGTGAATTCCTGACGCTG
CTGGGCGTCTTCCGGGTCAACACCTGGGTCGCGCTCTTTGCCGCCACCGGCGTCATCCTCTCGGCCGCCTATGCGCTCTG
GCTCTATCGCCGGGTGATCTTCGGCGCGCTCGAGAAGGAAAAGCTGAAGGCGCTGCTCGATCTTTCCAGACGCGAACAGC
TGATCCTCTACCCGCTGGTCGCACTGACCATCTTCTTCGGCGTTTACCCGGCCCCGGTCTTCGATGCGACGGCCGCCTCG
GTGGATCTGCTGGTCAACAACTACACGGCCGCCGTGCACGCAGCGCAGAATATTGCGCTGTCTATGAATTGA

Upstream 100 bases:

>100_bases
TCGTCCGCCTGCAGACCGGTTACCTCTATCACTATGCCTTCGCGATGCTGATCGGCATTGCGGCGCTTGTTACCTGGATG
ATGCTCGGGAGTTCCTTCTG

Downstream 100 bases:

>100_bases
TGACGGGACTTATCGGACATGACCGCTGAAACAATTCTCCTCAGTCTGCATCTTTCCGCGCCGGAGCTCATCCTCGCGGT
CGGCGCCCTTGTCCTGTTGA

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTDWPILTTVTFLPLVGVVLLLLMNGESETGRKNVLWISLITTVFTFIVSLFIWIGFDNANPGFQMLEKHDWLGTGIGYH
LGVDGISMLFVILSTFLMPFCVLASWLSIEKRLKEYMIAFLILETMMVGVFVSLDIVLFYVFFEAGLIPMFLIIGVWGGK
DRVYASYKFFLYTLLGSVLMLLAIMAMYWQAGTTDITALLAYKFPPALQTWLWLAFFASFAVKMPMWPVHTWLPDAHVQA
PTAGSVILAGVLLKLGGYGLIRFSLGMFPVASDYFAPFVFALSVIAIIYTSLVAMMQDDIKKLIAYSSVAHMGYVTMGIF
AANMQGVQGSIFQMLSHGIVSGALFLCVGVVYDRTHTREINAYGGLVNNMPKYAVAMMVFTMANVGLPGTSGFIGEFLTL
LGVFRVNTWVALFAATGVILSAAYALWLYRRVIFGALEKEKLKALLDLSRREQLILYPLVALTIFFGVYPAPVFDATAAS
VDLLVNNYTAAVHAAQNIALSMN

Sequences:

>Translated_503_residues
MTDWPILTTVTFLPLVGVVLLLLMNGESETGRKNVLWISLITTVFTFIVSLFIWIGFDNANPGFQMLEKHDWLGTGIGYH
LGVDGISMLFVILSTFLMPFCVLASWLSIEKRLKEYMIAFLILETMMVGVFVSLDIVLFYVFFEAGLIPMFLIIGVWGGK
DRVYASYKFFLYTLLGSVLMLLAIMAMYWQAGTTDITALLAYKFPPALQTWLWLAFFASFAVKMPMWPVHTWLPDAHVQA
PTAGSVILAGVLLKLGGYGLIRFSLGMFPVASDYFAPFVFALSVIAIIYTSLVAMMQDDIKKLIAYSSVAHMGYVTMGIF
AANMQGVQGSIFQMLSHGIVSGALFLCVGVVYDRTHTREINAYGGLVNNMPKYAVAMMVFTMANVGLPGTSGFIGEFLTL
LGVFRVNTWVALFAATGVILSAAYALWLYRRVIFGALEKEKLKALLDLSRREQLILYPLVALTIFFGVYPAPVFDATAAS
VDLLVNNYTAAVHAAQNIALSMN
>Mature_502_residues
TDWPILTTVTFLPLVGVVLLLLMNGESETGRKNVLWISLITTVFTFIVSLFIWIGFDNANPGFQMLEKHDWLGTGIGYHL
GVDGISMLFVILSTFLMPFCVLASWLSIEKRLKEYMIAFLILETMMVGVFVSLDIVLFYVFFEAGLIPMFLIIGVWGGKD
RVYASYKFFLYTLLGSVLMLLAIMAMYWQAGTTDITALLAYKFPPALQTWLWLAFFASFAVKMPMWPVHTWLPDAHVQAP
TAGSVILAGVLLKLGGYGLIRFSLGMFPVASDYFAPFVFALSVIAIIYTSLVAMMQDDIKKLIAYSSVAHMGYVTMGIFA
ANMQGVQGSIFQMLSHGIVSGALFLCVGVVYDRTHTREINAYGGLVNNMPKYAVAMMVFTMANVGLPGTSGFIGEFLTLL
GVFRVNTWVALFAATGVILSAAYALWLYRRVIFGALEKEKLKALLDLSRREQLILYPLVALTIFFGVYPAPVFDATAASV
DLLVNNYTAAVHAAQNIALSMN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=362, Percent_Identity=33.7016574585635, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI251831117, Length=429, Percent_Identity=23.7762237762238, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788613, Length=470, Percent_Identity=38.936170212766, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=27.5510204081633, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788831, Length=291, Percent_Identity=27.4914089347079, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788614, Length=488, Percent_Identity=25.8196721311475, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI145693160, Length=372, Percent_Identity=27.6881720430108, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI2367154, Length=251, Percent_Identity=26.6932270916335, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788829, Length=291, Percent_Identity=24.7422680412371, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55589; Mature: 55458

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TDWPILTTVTFLPLVGVVLLLLMNGESETGRKNVLWISLITTVFTFIVSLFIWIGFDNA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC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HHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]