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The map label for this gene is nuoL [H]

Identifier: 209548875

GI number: 209548875

Start: 1288093

End: 1290093

Strand: Direct

Name: nuoL [H]

Synonym: Rleg2_1272

Alternate gene names: 209548875

Gene position: 1288093-1290093 (Clockwise)

Preceding gene: 209548874

Following gene: 209548876

Centisome position: 28.38

GC content: 61.87

Gene sequence:

>2001_bases
ATGTTCCTCTATAAGGCTATCGTCTTTCTTCCCTTGATCGGTGCGATCGTTGCCGGCCTGTTCGGCCGCGCCATCGGCGC
CAAGGCTTCGGAATATGTCACCAGCGGCCTGATGATCATCGCCGCCATCCTCTCCTGGATCGTGTTCTTCACGGTCGGCA
TGGGCCATGCCGAAGGCGGCCCGATCAAGGTCGAGGTGCTGCGCTGGATCCAGTCCGGCGGCATCGACGTCTCCTGGTCG
CTGCGCGTGGATACGCTGACCTCCGTCATGCTGATCGTCGTCAACACGGTCTCGACGCTGGTTCACGTCTATTCGATCGG
TTACATGCACACCGATCCGCATCGCCCGCGCTTCTTTGCCTATCTCTCGCTCTTCACCTTCGCCATGCTGATGCTGGTGA
CGGCCGACAACCTGGCGCAGATGTTCTTCGGCTGGGAAGGCGTCGGTCTCGCCTCCTATCTGCTGATCGGCTTCTGGTTC
AAGAAGCCGTCGGCAACGGCTGCGGCGATGAAGGCCTTCATCGTCAACCGCGTCGGCGACTTCGGCTTCGTCCTCGGCAT
TGCCGGTGTCTTCGTGCTGTTCGGTTCGATCAACTTCGACACGATCTTCGCCAATGCCTCGAACTTCGCCCCGCATGAAG
GCGGCGGCGAGGCGAGCGAAGTCATCCTCAACCTCTTCGGCATGCAGCTCGACAAGGCGCACGCGCTGACCGGCGTCTGC
CTGCTGCTGTTCATGGGCGCCATGGGCAAGTCGGCGCAGTTCCTGCTCCATACCTGGCTGCCGGATGCCATGGAAGGCCC
GACCCCGGTCTCGGCCCTCATCCATGCCGCCACCATGGTCACCGCCGGCGTCTTTCTCGTCGCCCGCATGTCGCCGCTCT
TCGAACTGTCGCCGGATGCGCTCGTCGTCGTCACCGTGATCGGCGCGATCACCGCCTTCTTCGCGGCCACCGTCGGCCTC
GTGCAGAACGACATCAAGCGCGTCATCGCCTATTCCACCTGCTCGCAGCTCGGCTACATGTTCGTGGCGCTCGGGGTAGG
GGCCTATGGCGCGGCGATCTTCCATCTGTTCACGCACGCCTTCTTCAAGGCGCTGCTGTTCCTTTGCGCCGGCTCGGTCA
TCCATTCCGTCGATGGCGAGCAGGACATGCGCTACATGGGCGGCCTGTATCCGCATATCAAAGTTACCGGCATCCTGATG
ATCATCGGCACGCTGGCGATCACCGGCGTCGGCATTCCGTTCACGCCGATCGGCTTTGCCGGCTTCTTCTCCAAGGACGT
GATCATCGAGGCGACCTATGCTTCGCATTCGCCGGTTGCAGGCTTTGCTTTCTCGCTGCTGGTCATCGCGGCTCTGTTTA
CGAGCTTCTATTCCTGGCGCCTGATCTTCATGACCTTCTTCGGCAAGCCGCGCGCTTCGCACGAGGTCATGCACCACGTC
CATGAATCGCCGCAGGTCATGCTGGTGCCGCTCTATCTCCTGGCGATCGGCGCCGTGTTTGCCGGCGTGATCTTCGAAGG
CCGGTTCTACGGCGAGGAATATGCCGAGTTCTGGAAGGGCGCGCTGTTTACCGGCGCCGAGAACGAACTGGTCGAACAGT
TCCATCACGTGCCGGCGCTCGTGGGCCTGAGCCCCTTCATTGCCATGCTGCTCGGCTTCGTCCTCGCCTGGTACATGTAT
ATCCGTTCGCCGCAGACGCCGCGCACCCTCGCCAGGCAGCACCGCGTTCTCTACCAGTTCCTGCTGAACAAGTGGTACTT
CGACGAACTCTACGATTTCCTCTTCGTCCGCACCGCCAAGGCGCTTGGCCGCTTCCTGTGGAAGAAGGGTGATGTCGGCG
TCATCGACACCTATGGCCCGAACGGTGTGGCCGCCCGGGTCGTCGCCGTCACCGACCGCGTCGTCCGCCTGCAGACCGGT
TACCTCTATCACTATGCCTTCGCGATGCTGATCGGCATTGCGGCGCTTGTTACCTGGATGATGCTCGGGAGTTCCTTCTG
A

Upstream 100 bases:

>100_bases
GCCGAAGCGGCGATCGGTCTTGCAATTCTCGTTGTCTTCTACCGCAACCGCGGCTCGATCGCGGTCGAAGACGTCAATAT
GATGAAGGGCTGAGTGGCTC

Downstream 100 bases:

>100_bases
TGACCGATTGGCCTATTCTTACAACGGTCACCTTCCTGCCGCTCGTCGGCGTGGTGCTCCTGCTATTGATGAACGGCGAG
AGCGAAACCGGCCGCAAGAA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MFLYKAIVFLPLIGAIVAGLFGRAIGAKASEYVTSGLMIIAAILSWIVFFTVGMGHAEGGPIKVEVLRWIQSGGIDVSWS
LRVDTLTSVMLIVVNTVSTLVHVYSIGYMHTDPHRPRFFAYLSLFTFAMLMLVTADNLAQMFFGWEGVGLASYLLIGFWF
KKPSATAAAMKAFIVNRVGDFGFVLGIAGVFVLFGSINFDTIFANASNFAPHEGGGEASEVILNLFGMQLDKAHALTGVC
LLLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDALVVVTVIGAITAFFAATVGL
VQNDIKRVIAYSTCSQLGYMFVALGVGAYGAAIFHLFTHAFFKALLFLCAGSVIHSVDGEQDMRYMGGLYPHIKVTGILM
IIGTLAITGVGIPFTPIGFAGFFSKDVIIEATYASHSPVAGFAFSLLVIAALFTSFYSWRLIFMTFFGKPRASHEVMHHV
HESPQVMLVPLYLLAIGAVFAGVIFEGRFYGEEYAEFWKGALFTGAENELVEQFHHVPALVGLSPFIAMLLGFVLAWYMY
IRSPQTPRTLARQHRVLYQFLLNKWYFDELYDFLFVRTAKALGRFLWKKGDVGVIDTYGPNGVAARVVAVTDRVVRLQTG
YLYHYAFAMLIGIAALVTWMMLGSSF

Sequences:

>Translated_666_residues
MFLYKAIVFLPLIGAIVAGLFGRAIGAKASEYVTSGLMIIAAILSWIVFFTVGMGHAEGGPIKVEVLRWIQSGGIDVSWS
LRVDTLTSVMLIVVNTVSTLVHVYSIGYMHTDPHRPRFFAYLSLFTFAMLMLVTADNLAQMFFGWEGVGLASYLLIGFWF
KKPSATAAAMKAFIVNRVGDFGFVLGIAGVFVLFGSINFDTIFANASNFAPHEGGGEASEVILNLFGMQLDKAHALTGVC
LLLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDALVVVTVIGAITAFFAATVGL
VQNDIKRVIAYSTCSQLGYMFVALGVGAYGAAIFHLFTHAFFKALLFLCAGSVIHSVDGEQDMRYMGGLYPHIKVTGILM
IIGTLAITGVGIPFTPIGFAGFFSKDVIIEATYASHSPVAGFAFSLLVIAALFTSFYSWRLIFMTFFGKPRASHEVMHHV
HESPQVMLVPLYLLAIGAVFAGVIFEGRFYGEEYAEFWKGALFTGAENELVEQFHHVPALVGLSPFIAMLLGFVLAWYMY
IRSPQTPRTLARQHRVLYQFLLNKWYFDELYDFLFVRTAKALGRFLWKKGDVGVIDTYGPNGVAARVVAVTDRVVRLQTG
YLYHYAFAMLIGIAALVTWMMLGSSF
>Mature_666_residues
MFLYKAIVFLPLIGAIVAGLFGRAIGAKASEYVTSGLMIIAAILSWIVFFTVGMGHAEGGPIKVEVLRWIQSGGIDVSWS
LRVDTLTSVMLIVVNTVSTLVHVYSIGYMHTDPHRPRFFAYLSLFTFAMLMLVTADNLAQMFFGWEGVGLASYLLIGFWF
KKPSATAAAMKAFIVNRVGDFGFVLGIAGVFVLFGSINFDTIFANASNFAPHEGGGEASEVILNLFGMQLDKAHALTGVC
LLLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFLVARMSPLFELSPDALVVVTVIGAITAFFAATVGL
VQNDIKRVIAYSTCSQLGYMFVALGVGAYGAAIFHLFTHAFFKALLFLCAGSVIHSVDGEQDMRYMGGLYPHIKVTGILM
IIGTLAITGVGIPFTPIGFAGFFSKDVIIEATYASHSPVAGFAFSLLVIAALFTSFYSWRLIFMTFFGKPRASHEVMHHV
HESPQVMLVPLYLLAIGAVFAGVIFEGRFYGEEYAEFWKGALFTGAENELVEQFHHVPALVGLSPFIAMLLGFVLAWYMY
IRSPQTPRTLARQHRVLYQFLLNKWYFDELYDFLFVRTAKALGRFLWKKGDVGVIDTYGPNGVAARVVAVTDRVVRLQTG
YLYHYAFAMLIGIAALVTWMMLGSSF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cellular chromatophore membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=462, Percent_Identity=39.8268398268398, Blast_Score=317, Evalue=3e-86,
Organism=Escherichia coli, GI1788614, Length=596, Percent_Identity=39.261744966443, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788829, Length=440, Percent_Identity=29.5454545454545, Blast_Score=143, Evalue=5e-35,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=32.1022727272727, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1788827, Length=446, Percent_Identity=28.0269058295964, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788613, Length=430, Percent_Identity=26.046511627907, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693160, Length=373, Percent_Identity=25.7372654155496, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI2367154, Length=224, Percent_Identity=29.0178571428571, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 72886; Mature: 72886

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCC
>Mature Secondary Structure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HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]