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The map label for this gene is nuoF1 [H]

Identifier: 209548868

GI number: 209548868

Start: 1281131

End: 1282435

Strand: Direct

Name: nuoF1 [H]

Synonym: Rleg2_1265

Alternate gene names: 209548868

Gene position: 1281131-1282435 (Clockwise)

Preceding gene: 209548867

Following gene: 209548869

Centisome position: 28.23

GC content: 63.37

Gene sequence:

>1305_bases
ATGTTACAAGATAAAGACCGCATCTTTACCAACATCTACGGCCTCAAGGACAAGTCCCTGAAGGGCGCGATGAGCCGCGG
CCACTGGGACGGCACCAAGCAGATCCTCGAAAAGGGCCGCGACTGGATCATCAACGAGATGAAGGCCTCGGGCCTTCGCG
GCCGCGGCGGCGCCGGCTTCCCGACCGGCCTCAAATGGTCCTTCATGCCGAAGGAAAGCGACGGCCGCCCGCATTACCTC
GTCGTCAATGCCGACGAATCGGAGCCCGGCACCTGCAAGGACCGCGACATCATGCGCCACGATCCGCATACGCTGATCGA
AGGCTGCGTCGTCGCCAGCTTTGCCATGGGCGCCAATGCCGCCTACATCTATGTGCGCGGCGAATATATCCGCGAGCGCG
AAGCGCTGCAGGCGGCGATCGACGAATGCTATGATTACGGCCTGCTCGGCAAGAACAACAAGCTCGGCTGGGACATGGAC
ATCTTCGTCCATCACGGCGCCGGCGCCTATATCTGCGGCGAGGAAACCGCGCTGCTCGAAAGCCTCGAGGGCAAGAAGGG
CCAGCCGCGCCTGAAGCCGCCATTCCCGGCCAATATGGGCCTCTACGGCTGCCCGACGACTGTTAATAACGTCGAATCGA
TCGCCGTTGCCCCGACGATCCTGCGCCGCGGCGCCGGCTGGTTCTCGGCCATCGGCCGCCCGAACAATGTCGGCACCAAG
CTGTTCATGCTCTCCGGCCACGTCAACAAGCCGTGCACCGTCGAAGAGGAAATGGGCATTACCTTCCGCGAGCTGGTCGA
CCGCCATGCCGGCGGCATCCGCGGCGGCTGGGATAATCTGCTCGCCGTCATTCCGGGCGGCGCATCCTGCCCGATCGTTC
CGGCCAAGGACATCATCGACTGCCCAATGGATTTCGACGGCCTGCGCGGCGTCGGCTCCTCCTTCGGCACGGCGGCTGCG
ATCGTCATGGACAAGTCCACCGACGTCATCAAGGCGATCGCCCGCATCTCCGCCTTCTTCAAGCATGAGAGCTGCGGCCA
GTGCACGCCCTGCCGCGAAGGCACGGGCTGGATGTGGCGCGTGATGGAGCGCATGGCCAAGGGCAATGCCCAGAAGCGCG
AAATCGACATGCTGTTCCAGGTGACCAAGCAGATCGAAGGCCACACCATCTGCGCGCTCGGCGATGCCGCCGCATGGCCG
GTGCAGGGTCTGATCCGTAACTTCCGTCCCGAGATCGAAAAGCGCATCGACCAGTATACGGCAAGCGCGCTCGATCACGG
TGCGGTTCTGGAGGCGGCTGAATAA

Upstream 100 bases:

>100_bases
GAGCGCGACGACTGGGTCAAGCAGGCCAAGGCGCTCGCCAAGGGCGGCGAAGCGGAATATATCAAGGTCTTCGGCAAGAA
GCCGCGGTAAGAGGTGAAGC

Downstream 100 bases:

>100_bases
TCATGGCGGACAACGCATCGAAGAGTGGAAAGAAGGAAGACGCCGCCGATTTCGCGGCCGGCTTCGGCCGTCTTGCCGCC
GAGATGCTGGAAAATGCACG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLQDKDRIFTNIYGLKDKSLKGAMSRGHWDGTKQILEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKESDGRPHYL
VVNADESEPGTCKDRDIMRHDPHTLIEGCVVASFAMGANAAYIYVRGEYIREREALQAAIDECYDYGLLGKNNKLGWDMD
IFVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAGWFSAIGRPNNVGTK
LFMLSGHVNKPCTVEEEMGITFRELVDRHAGGIRGGWDNLLAVIPGGASCPIVPAKDIIDCPMDFDGLRGVGSSFGTAAA
IVMDKSTDVIKAIARISAFFKHESCGQCTPCREGTGWMWRVMERMAKGNAQKREIDMLFQVTKQIEGHTICALGDAAAWP
VQGLIRNFRPEIEKRIDQYTASALDHGAVLEAAE

Sequences:

>Translated_434_residues
MLQDKDRIFTNIYGLKDKSLKGAMSRGHWDGTKQILEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKESDGRPHYL
VVNADESEPGTCKDRDIMRHDPHTLIEGCVVASFAMGANAAYIYVRGEYIREREALQAAIDECYDYGLLGKNNKLGWDMD
IFVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAGWFSAIGRPNNVGTK
LFMLSGHVNKPCTVEEEMGITFRELVDRHAGGIRGGWDNLLAVIPGGASCPIVPAKDIIDCPMDFDGLRGVGSSFGTAAA
IVMDKSTDVIKAIARISAFFKHESCGQCTPCREGTGWMWRVMERMAKGNAQKREIDMLFQVTKQIEGHTICALGDAAAWP
VQGLIRNFRPEIEKRIDQYTASALDHGAVLEAAE
>Mature_434_residues
MLQDKDRIFTNIYGLKDKSLKGAMSRGHWDGTKQILEKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKESDGRPHYL
VVNADESEPGTCKDRDIMRHDPHTLIEGCVVASFAMGANAAYIYVRGEYIREREALQAAIDECYDYGLLGKNNKLGWDMD
IFVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAGWFSAIGRPNNVGTK
LFMLSGHVNKPCTVEEEMGITFRELVDRHAGGIRGGWDNLLAVIPGGASCPIVPAKDIIDCPMDFDGLRGVGSSFGTAAA
IVMDKSTDVIKAIARISAFFKHESCGQCTPCREGTGWMWRVMERMAKGNAQKREIDMLFQVTKQIEGHTICALGDAAAWP
VQGLIRNFRPEIEKRIDQYTASALDHGAVLEAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=66.3484486873508, Blast_Score=596, Evalue=1e-170,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=66.3484486873508, Blast_Score=595, Evalue=1e-170,
Organism=Escherichia coli, GI1788620, Length=397, Percent_Identity=43.8287153652393, Blast_Score=328, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=424, Percent_Identity=64.622641509434, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI19920794, Length=419, Percent_Identity=68.9737470167064, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI45550452, Length=432, Percent_Identity=64.3518518518518, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24653819, Length=421, Percent_Identity=46.0807600950119, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24653817, Length=421, Percent_Identity=42.7553444180523, Blast_Score=347, Evalue=8e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47569; Mature: 47569

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNIYGLKDKSLKGAMSRGHWDGTKQILEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESDGRPHYLVVNADESEPGTCKDRDIMRHDPHTLIEGCVVASFAMGANA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCE
AYIYVRGEYIREREALQAAIDECYDYGLLGKNNKLGWDMDIFVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAGWFSAIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCE
LFMLSGHVNKPCTVEEEMGITFRELVDRHAGGIRGGWDNLLAVIPGGASCPIVPAKDIID
EEEEECCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHHC
CPMDFDGLRGVGSSFGTAAAIVMDKSTDVIKAIARISAFFKHESCGQCTPCREGTGWMWR
CCCCCCHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERMAKGNAQKREIDMLFQVTKQIEGHTICALGDAAAWPVQGLIRNFRPEIEKRIDQYT
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
ASALDHGAVLEAAE
HHHHCCCCEEECCC
>Mature Secondary Structure
MLQDKDRIFTNIYGLKDKSLKGAMSRGHWDGTKQILEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESDGRPHYLVVNADESEPGTCKDRDIMRHDPHTLIEGCVVASFAMGANA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCE
AYIYVRGEYIREREALQAAIDECYDYGLLGKNNKLGWDMDIFVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAGWFSAIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCE
LFMLSGHVNKPCTVEEEMGITFRELVDRHAGGIRGGWDNLLAVIPGGASCPIVPAKDIID
EEEEECCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHHC
CPMDFDGLRGVGSSFGTAAAIVMDKSTDVIKAIARISAFFKHESCGQCTPCREGTGWMWR
CCCCCCHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERMAKGNAQKREIDMLFQVTKQIEGHTICALGDAAAWPVQGLIRNFRPEIEKRIDQYT
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
ASALDHGAVLEAAE
HHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]