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The map label for this gene is nuoD1 [H]

Identifier: 209548865

GI number: 209548865

Start: 1278475

End: 1279665

Strand: Direct

Name: nuoD1 [H]

Synonym: Rleg2_1262

Alternate gene names: 209548865

Gene position: 1278475-1279665 (Clockwise)

Preceding gene: 209548864

Following gene: 209548866

Centisome position: 28.17

GC content: 61.46

Gene sequence:

>1191_bases
ATGACAGAACATAACGTCCGCAACTTCAACATCAATTTCGGACCGCAGCATCCGGCGGCGCACGGCGTTCTTCGTCTTGT
CCTGGAGCTTGACGGCGAAATTGTGGAGCGGGTTGATCCGCATATCGGCCTGCTGCACCGCGGCACCGAGAAGCTGATCG
AGACCAAGACCTATCTTCAGGCCGTGCCCTATTTCGATCGGCTCGATTACGTGGCGCCGATGAACCAGGAGCATGCTTAT
GCGCTGGCGGTGGAAAAGCTGCTCGGCATCGAGATCCCGATTCGCGGCCAGCTGATCCGCGTTCTCTATTCCGAAATCGG
CCGCATCCTCTCGCATCTGTTGAACGTCACGACGCAGGCCATGGACGTCGGGGCGCTGACGCCGCCGCTCTGGGGCTTCG
AAGAGCGTGAAAAGCTGATGGTGTTCTACGAGCGCGCCAGCGGCTCGCGCATGCATGCCGCTTATGTCCGTCCGGGCGGC
GTCCACCAGGACCTGCCGGAACAGCTCGTCCAGGATATCGGCGACTGGTGCGATCCCTTCCTCAAGGCGCTCGACGATAT
CGACAATCTGTTGACCGGCAACCGCATCTTCAAGCAGCGCAACGTCGATATCGGCGTCGTCTCGCTGGAGGATTGCTGGG
CCTGGGGCTTCTCCGGCGTCATGGTGCGCGGTTCGGGCGCTGCCTGGGATCTGCGCCGCTCCCAGCCTTACGAATGTTAC
TCCGATCTCGAATTCGACATTCCGATCGGCAAGAACGGCGACAACTACGACCGCTACCTGATCCGCATGATCGAGATGCG
CCAGTCGGTCCGCATCATGAAGCAATGCGTCAACCGCCTGCTGTCGGATGCCAAGACCGGTCCTTTCTCGTCGATCGACG
GCAAGGTCGTGCCGCCGAAGCGCGGTGAGATGAAGCGCTCGATGGAAGCGCTGATCCACCACTTCAAGCTCTATACCGAA
GGCTACCACGTGCCGGCCGGCGAAGTTTACGCCGCGGTCGAAGCGCCGAAGGGCGAGTTCGGCGTCTATCTCGTCTCCGA
CGGCTCCAACAAGCCCTATCGCTGCAAGATCCGTGCGCCCGGTTATGCGCATCTGCAGGCGATGGATTTCATGTGCCGCG
GCCACCAGCTTGCCGACGTCGCAGCCGTGCTCGGCTCGCTCGACATCGTCTTCGGCGAGGTGGACCGCTGA

Upstream 100 bases:

>100_bases
CGTGCTGCCCGGCGATGAAAAAGCGAAGCAATAAATTCAAGGCGGCTGGTGGGTTTGTGCCTGCCATTCACTGGTTATCT
GAGAACGCGAGCGCATCGCC

Downstream 100 bases:

>100_bases
TGCAGCGTCTGCCGCTTGCCGTCGCACTTCTTCTTGCGGCATCCGGGGTTTCGGCCCAGGAGACCGATACGCTCGGCACG
CCGCTGGGCCGTAAGGAAGT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 1; NDH-1 subunit D 1 [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIETKTYLQAVPYFDRLDYVAPMNQEHAY
ALAVEKLLGIEIPIRGQLIRVLYSEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYVRPGG
VHQDLPEQLVQDIGDWCDPFLKALDDIDNLLTGNRIFKQRNVDIGVVSLEDCWAWGFSGVMVRGSGAAWDLRRSQPYECY
SDLEFDIPIGKNGDNYDRYLIRMIEMRQSVRIMKQCVNRLLSDAKTGPFSSIDGKVVPPKRGEMKRSMEALIHHFKLYTE
GYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKIRAPGYAHLQAMDFMCRGHQLADVAAVLGSLDIVFGEVDR

Sequences:

>Translated_396_residues
MTEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIETKTYLQAVPYFDRLDYVAPMNQEHAY
ALAVEKLLGIEIPIRGQLIRVLYSEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYVRPGG
VHQDLPEQLVQDIGDWCDPFLKALDDIDNLLTGNRIFKQRNVDIGVVSLEDCWAWGFSGVMVRGSGAAWDLRRSQPYECY
SDLEFDIPIGKNGDNYDRYLIRMIEMRQSVRIMKQCVNRLLSDAKTGPFSSIDGKVVPPKRGEMKRSMEALIHHFKLYTE
GYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKIRAPGYAHLQAMDFMCRGHQLADVAAVLGSLDIVFGEVDR
>Mature_395_residues
TEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIETKTYLQAVPYFDRLDYVAPMNQEHAYA
LAVEKLLGIEIPIRGQLIRVLYSEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYVRPGGV
HQDLPEQLVQDIGDWCDPFLKALDDIDNLLTGNRIFKQRNVDIGVVSLEDCWAWGFSGVMVRGSGAAWDLRRSQPYECYS
DLEFDIPIGKNGDNYDRYLIRMIEMRQSVRIMKQCVNRLLSDAKTGPFSSIDGKVVPPKRGEMKRSMEALIHHFKLYTEG
YHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKIRAPGYAHLQAMDFMCRGHQLADVAAVLGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=64.9616368286445, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=64.1558441558442, Blast_Score=510, Evalue=1e-145,
Organism=Escherichia coli, GI145693162, Length=390, Percent_Identity=39.2307692307692, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789076, Length=392, Percent_Identity=25.765306122449, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788832, Length=389, Percent_Identity=26.7352185089974, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=61.1675126903553, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=60.9137055837564, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=62.9441624365482, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI221459469, Length=395, Percent_Identity=54.9367088607595, Blast_Score=465, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44730; Mature: 44599

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIETKTYLQ
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHHHH
AVPYFDRLDYVAPMNQEHAYALAVEKLLGIEIPIRGQLIRVLYSEIGRILSHLLNVTTQA
HCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYVRPGGVHQDLPEQLVQDIGDWCDPF
HHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
LKALDDIDNLLTGNRIFKQRNVDIGVVSLEDCWAWGFSGVMVRGSGAAWDLRRSQPYECY
HHHHHHHHHHHCCCHHHHHCCCCEEEEEHHHHHHCCCCCEEEECCCCEEECCCCCCCCHH
SDLEFDIPIGKNGDNYDRYLIRMIEMRQSVRIMKQCVNRLLSDAKTGPFSSIDGKVVPPK
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCC
RGEMKRSMEALIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKIRAP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECC
GYAHLQAMDFMCRGHQLADVAAVLGSLDIVFGEVDR
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
TEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIETKTYLQ
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHHHH
AVPYFDRLDYVAPMNQEHAYALAVEKLLGIEIPIRGQLIRVLYSEIGRILSHLLNVTTQA
HCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYVRPGGVHQDLPEQLVQDIGDWCDPF
HHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
LKALDDIDNLLTGNRIFKQRNVDIGVVSLEDCWAWGFSGVMVRGSGAAWDLRRSQPYECY
HHHHHHHHHHHCCCHHHHHCCCCEEEEEHHHHHHCCCCCEEEECCCCEEECCCCCCCCHH
SDLEFDIPIGKNGDNYDRYLIRMIEMRQSVRIMKQCVNRLLSDAKTGPFSSIDGKVVPPK
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCC
RGEMKRSMEALIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKIRAP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECC
GYAHLQAMDFMCRGHQLADVAAVLGSLDIVFGEVDR
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA