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The map label for this gene is ppx [H]

Identifier: 209548702

GI number: 209548702

Start: 1120025

End: 1121545

Strand: Direct

Name: ppx [H]

Synonym: Rleg2_1099

Alternate gene names: 209548702

Gene position: 1120025-1121545 (Clockwise)

Preceding gene: 209548701

Following gene: 209548707

Centisome position: 24.68

GC content: 64.17

Gene sequence:

>1521_bases
ATGGTTGAATCTGAAGCCCAGGGGCGCCTTCCGGGGATCGCCCCGGTCTCCGTTGTCGACATTGGATCGAATTCCATTCG
TCTCGTCGTCTACGAAGGCATGTCCCGCTCGCCGACCATTCTTTTCAACGAAAAGGTTCTCTGCGGCCTCGGCAAAGGCA
TAGCCGTCACCGGCAAGATGGATGAAGACAGCGTCATCAGGGCTCTGGCGGCGCTGCACCGTTTCAAGGCCCTGTCCGAT
CAGGCACGCGCCGCCACCATGTATGTGCTGGCGACGGCCGCCGCCCGCGAGGCGAGCAACGGTCCCGATTTCATCCACCA
GGCGGAAACCATCCTCGGCCGCAAGGTCCGTGTGCTCTCCGGCGAGGAGGAGGCGAAATTCGCCTCGCTCGGCATCATCA
GCGGCTTCTTCAATCCCGACGGCATTGCCGGCGACCTCGGCGGCGGCTCGCTTGAGCTGATCGATATCAGGGGCAAGGAG
TTCGGCAAGGGCATCACGCTGCCGCTCGGCGGCCTGCGCCTGTCGGAATATGCCGGCGGCTCGCTCTCCAAGGCCCGCAC
CTTTGCCCGCAAGCAGGTGAAGACCGCAAAGCTGCTGTCGAAAGGCGAGGGGCGCACCTTCTACGCCGTCGGCGGCACAT
GGCGAAACATCGCCAAGCTGCATATGGAAATCACCAATTATCCGCTGCACATGATGCAGGGCTACGAGGTATCGCTTGAA
GCGATGATGCTGTTCCTCGAACAGGTGGTGACCGCGCGCGATTCGAAGGAGCCTGCGTTTCAGGCCGTCTCCAAGCACCG
CCGGTCGCTGCTGCCCTTCGGCGCCGTCGCCATGACGGAAGTGCTGAGCGCGATGAAACCGTCGGTGATTTCCTTCTCGG
CGCAGGGCGTGCGTGAGGGATATCTCTATTCGCTGCTGTCGGAGGCCGAGCGCCGCCTCGATCCGCTGCTGGCCGCTGCC
GGCGAGCTGGCGATCCTGCGTGCCCGTTCGCCCGAGCATGCCCGCGAGCTGGCGGAATGGACCGGCCGCATGATGCCCTT
GTTCGGCGTCCAGGAAACCGACGAGGAAAGCCGCTATCGTCAGGCCGCCTGTCTGCTGGCCGATATCAGCTGGCGCGCCC
ATCCCGACTATCGCGGCCTGCAGGCGCTGAACGTCATCGCCCACTCCTCCTTCGTCGGCATCAGCCATCCTGGCCGCGCC
TTCATCGCGCTGACCAACTACTACCGTTTCGAAGGCCTGCACGATGACGGCGCCACCGGCCCGCTGGCGCAGATCGCCAC
AGCCCAGTTCATCGAGCGCGCCAAGCTGCTCGGCGGCATGCTGCGCGTCGTCTACCTCTTCTCGGCCTCAATGCCCGGCA
TCGTCAAAAGCCTGAGCTTCCGCAAATCGTCGAACCCGGACCTCGACCTCGAATTCGTCGTGCCGCCCGAATACCGCGAT
TTCGCCGGCGAACGCCTGGACGGGCGCCTGCAGCAGCTGTCGAAGCTGACGAACAAGAGGCTGGCGTTCCGGTTCGAGTA
G

Upstream 100 bases:

>100_bases
TCCGAGCCTGTCAGGCCGTGGTGAAGCTCTGAAGTCCAGCGCGCCGAAACTGATCGCCGGCCTGCTCGAAGGCCGCAACA
ACAAGTAAAACTGGACCTAA

Downstream 100 bases:

>100_bases
TCTGCGGGAGGCGTTGTGCCGTGCCAGCCCCCTCTGGCCTGCCGGCCATCTCCCCCACAGGTGGGGAGATCGGCTGGGCG
CACCGATTTCCCAAAACTTG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MVESEAQGRLPGIAPVSVVDIGSNSIRLVVYEGMSRSPTILFNEKVLCGLGKGIAVTGKMDEDSVIRALAALHRFKALSD
QARAATMYVLATAAAREASNGPDFIHQAETILGRKVRVLSGEEEAKFASLGIISGFFNPDGIAGDLGGGSLELIDIRGKE
FGKGITLPLGGLRLSEYAGGSLSKARTFARKQVKTAKLLSKGEGRTFYAVGGTWRNIAKLHMEITNYPLHMMQGYEVSLE
AMMLFLEQVVTARDSKEPAFQAVSKHRRSLLPFGAVAMTEVLSAMKPSVISFSAQGVREGYLYSLLSEAERRLDPLLAAA
GELAILRARSPEHARELAEWTGRMMPLFGVQETDEESRYRQAACLLADISWRAHPDYRGLQALNVIAHSSFVGISHPGRA
FIALTNYYRFEGLHDDGATGPLAQIATAQFIERAKLLGGMLRVVYLFSASMPGIVKSLSFRKSSNPDLDLEFVVPPEYRD
FAGERLDGRLQQLSKLTNKRLAFRFE

Sequences:

>Translated_506_residues
MVESEAQGRLPGIAPVSVVDIGSNSIRLVVYEGMSRSPTILFNEKVLCGLGKGIAVTGKMDEDSVIRALAALHRFKALSD
QARAATMYVLATAAAREASNGPDFIHQAETILGRKVRVLSGEEEAKFASLGIISGFFNPDGIAGDLGGGSLELIDIRGKE
FGKGITLPLGGLRLSEYAGGSLSKARTFARKQVKTAKLLSKGEGRTFYAVGGTWRNIAKLHMEITNYPLHMMQGYEVSLE
AMMLFLEQVVTARDSKEPAFQAVSKHRRSLLPFGAVAMTEVLSAMKPSVISFSAQGVREGYLYSLLSEAERRLDPLLAAA
GELAILRARSPEHARELAEWTGRMMPLFGVQETDEESRYRQAACLLADISWRAHPDYRGLQALNVIAHSSFVGISHPGRA
FIALTNYYRFEGLHDDGATGPLAQIATAQFIERAKLLGGMLRVVYLFSASMPGIVKSLSFRKSSNPDLDLEFVVPPEYRD
FAGERLDGRLQQLSKLTNKRLAFRFE
>Mature_506_residues
MVESEAQGRLPGIAPVSVVDIGSNSIRLVVYEGMSRSPTILFNEKVLCGLGKGIAVTGKMDEDSVIRALAALHRFKALSD
QARAATMYVLATAAAREASNGPDFIHQAETILGRKVRVLSGEEEAKFASLGIISGFFNPDGIAGDLGGGSLELIDIRGKE
FGKGITLPLGGLRLSEYAGGSLSKARTFARKQVKTAKLLSKGEGRTFYAVGGTWRNIAKLHMEITNYPLHMMQGYEVSLE
AMMLFLEQVVTARDSKEPAFQAVSKHRRSLLPFGAVAMTEVLSAMKPSVISFSAQGVREGYLYSLLSEAERRLDPLLAAA
GELAILRARSPEHARELAEWTGRMMPLFGVQETDEESRYRQAACLLADISWRAHPDYRGLQALNVIAHSSFVGISHPGRA
FIALTNYYRFEGLHDDGATGPLAQIATAQFIERAKLLGGMLRVVYLFSASMPGIVKSLSFRKSSNPDLDLEFVVPPEYRD
FAGERLDGRLQQLSKLTNKRLAFRFE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=301, Percent_Identity=23.5880398671096, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788848, Length=401, Percent_Identity=22.4438902743142, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321185, Length=481, Percent_Identity=26.8191268191268, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55307; Mature: 55307

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESEAQGRLPGIAPVSVVDIGSNSIRLVVYEGMSRSPTILFNEKVLCGLGKGIAVTGKM
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCEEEECCCCEEEECCC
DEDSVIRALAALHRFKALSDQARAATMYVLATAAAREASNGPDFIHQAETILGRKVRVLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEC
GEEEAKFASLGIISGFFNPDGIAGDLGGGSLELIDIRGKEFGKGITLPLGGLRLSEYAGG
CCCHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEEECCCHHCCCCEECCCCEEEHHCCCC
SLSKARTFARKQVKTAKLLSKGEGRTFYAVGGTWRNIAKLHMEITNYPLHMMQGYEVSLE
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCCCCHHHH
AMMLFLEQVVTARDSKEPAFQAVSKHRRSLLPFGAVAMTEVLSAMKPSVISFSAQGVREG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHH
YLYSLLSEAERRLDPLLAAAGELAILRARSPEHARELAEWTGRMMPLFGVQETDEESRYR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHH
QAACLLADISWRAHPDYRGLQALNVIAHSSFVGISHPGRAFIALTNYYRFEGLHDDGATG
HHHHHHEECCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEEEEEEEHEECCCCCCCCCC
PLAQIATAQFIERAKLLGGMLRVVYLFSASMPGIVKSLSFRKSSNPDLDLEFVVPPEYRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCHHH
FAGERLDGRLQQLSKLTNKRLAFRFE
HCCCHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MVESEAQGRLPGIAPVSVVDIGSNSIRLVVYEGMSRSPTILFNEKVLCGLGKGIAVTGKM
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCEEEECCCCEEEECCC
DEDSVIRALAALHRFKALSDQARAATMYVLATAAAREASNGPDFIHQAETILGRKVRVLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEC
GEEEAKFASLGIISGFFNPDGIAGDLGGGSLELIDIRGKEFGKGITLPLGGLRLSEYAGG
CCCHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEEECCCHHCCCCEECCCCEEEHHCCCC
SLSKARTFARKQVKTAKLLSKGEGRTFYAVGGTWRNIAKLHMEITNYPLHMMQGYEVSLE
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCCCCHHHH
AMMLFLEQVVTARDSKEPAFQAVSKHRRSLLPFGAVAMTEVLSAMKPSVISFSAQGVREG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHH
YLYSLLSEAERRLDPLLAAAGELAILRARSPEHARELAEWTGRMMPLFGVQETDEESRYR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHH
QAACLLADISWRAHPDYRGLQALNVIAHSSFVGISHPGRAFIALTNYYRFEGLHDDGATG
HHHHHHEECCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEEEEEEEHEECCCCCCCCCC
PLAQIATAQFIERAKLLGGMLRVVYLFSASMPGIVKSLSFRKSSNPDLDLEFVVPPEYRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCHHH
FAGERLDGRLQQLSKLTNKRLAFRFE
HCCCHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]