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The map label for this gene is uvrC [H]

Identifier: 209548689

GI number: 209548689

Start: 1104276

End: 1106318

Strand: Reverse

Name: uvrC [H]

Synonym: Rleg2_1086

Alternate gene names: 209548689

Gene position: 1106318-1104276 (Counterclockwise)

Preceding gene: 209548690

Following gene: 209548688

Centisome position: 24.38

GC content: 63.49

Gene sequence:

>2043_bases
ATGAATGGACGAAAGCTGCCGGATGGCGGCGTTCTCTACGACGATACGGATGAGAGCGAAGACGAGATCGAGGTGGAAGG
CGACCTTTCCGCCGCCGCCCCGCTTGCGACTGCGGTCGACTGGAACGCCGGCAGCCTCAACGAGACCGGCCTCATCGGCG
CCGAACTGATCGGCGAATTCGTCAAGCGGCTGCCGAACAGCCCCGGCGTCTACCGCATGTTCAATGCCGAGGGCGACGTG
CTCTATGTCGGCAAGGCGCGCAGCCTGAAGAAGCGCGTCGGCAATTACGCCGTCGGCCGCGTGCATTCCAACCGCATCGC
CCAGATGGTGCGCCAGACGGCGAATATGGAATTCGTGACGACGCGCACGGAAACCGAAGCGCTTCTCCTGGAAGCGAATC
TGATCAAGCGCTTGCGGCCGCGCTTTAACGTTCTGCTGCGCGACGACAAGTCCTTTCCCTATATCCTCATCACCGGCGAC
CATCGGGCGCCGGCCATTTTCAAGCATCGCGGCGCGCGGGCCAGAAAGGGTGACTACTTCGGGCCCTTCGCTTCGGCCGG
CGCGGTCGGGCGGACGATCAATTCGCTGCAGCGTGCCTTCCTGATCCGCACCTGCACCGACAGCGTCTTCGAAACACGCA
CGCGTCCCTGCCTGCTCTATCAGATCAAGCGCTGTTCCGGGCCGTGCACCCATGAGGTCAGCGATGCGGGTTACGGCGAA
CTGGTGCAGGAGGCGAAGGACTTCCTCTCCGGCAAGAGCCAGAAGGTGAAGTCGCACATGGCCGAAGCCATGAACCAGGC
GGCCGAGGACCTCGATTTCGAGCGGGCAGCTATCTATCGCGACCGCCTGGCCGCACTTTCGCATGTGCAGAGCCACCAGG
GCATCAATCCGGCCGGCGTCGAAGAGGCGGATGTTTTCGCCATCCATCACGAAGGCGGCGTCTCCTGCATCCAGGTGTTC
TTCTTCCGCACCGGCCAGAACTGGGGCAACCGCGCCTATTTCCCCAAGGCCGATCCGCAGCTTTCCGGCGCCGAAGTGCT
GAATGCCTTCCTCGCCCAGTTCTATGACGACAAGCCGGTGCCGAAGCAGATCATGCTGTCGGAAACGATCGAAGAGATGG
AGCTGCTTGCCGCAGCGCTCAGTGAAAAGGCCGGCCACAAGGTTGCGATCCTCGTGCCGCGGCGCGGTGAGAAACGCGAT
CTCGTCGACCATGTCGTCGGCAATGCGCGCGAGGCGCATGGGCGCAAGCTTGCCGAGACGGCGTCGCAATCGCGGCTGCT
CGAAGGTTTCAAGGAGACGTTCGGGCTTGCCTATGCGCCGCAGCGCATCGAGATCTACGACAACTCGCATATCATGGGCA
CCAACGCCGTCGGCGGCATGGTGGTCGCGGGACCGGAAGGTTTCGTCAAGAACCAGTACCGCAAGTTCAACATCAAATCG
ACCGACATCACCCCCGGCGACGACTTCGGCATGATGAAGGAGGTGATGACGCGGCGGTTCTCGCGGCTGATCAAGGAGGA
AGGCATTCCCGACCGGACGGCGCAGGCAACCGCAGCCGACGCTGCCGACATGCCGTTTCCGACCTGGCCCGACGTGATCC
TCATCGACGGCGGCCAGGGCCAGATGACGGCGGTGCGCGCCATCCTCACCGAACTCGGCATCACCGACAGTGTGACGGCG
ATCGGCATCGCCAAGGGTGTCGACCGCGATGCCGGGCGCGAGCGCTTCTTCCCGCCGGGACGCGAGAGTTTTACCCTGCC
GCCGCGCGATCCGGTGCTCTATTTCGTCCAGCGCATGCGCGACGAGGCGCATCGTTTCGCGATCGGCTCGCACCGGGCCC
GGCGCAAGAAGGAAATGGTCAAGAACCCGCTCGACGAGATCGGCGGCATCGGCCCATCGCGCAAGCGCGCGCTGCTTCAG
CATTTCGGCACGGCAAAAGCGGTTTCGCGCGCCGCACTCTCCGACCTGATGGCGGTGGAAGGTATTTCGGAAGCCGTCGC
CAAGCAGGTCTACAACCATTTCCACGACGACGCCGCGAAATAA

Upstream 100 bases:

>100_bases
GCTTTCTCTTCGACACGCCCTCGATCACCGGCCAGATGATTGCCCTCGATGGCGGCCAGCACCTCGCCTGGCAGACGCCC
GATGTGGCGGAGATTACGGA

Downstream 100 bases:

>100_bases
CCGGCGCCCGTCGCAAATTCCACGCAAAGGCAGTGAAAAGACAGAAAGAATGTTGACGGTCCGCGGTCAAAGCCGTCATC
TACCGCATCGGCCCGAAAAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MNGRKLPDGGVLYDDTDESEDEIEVEGDLSAAAPLATAVDWNAGSLNETGLIGAELIGEFVKRLPNSPGVYRMFNAEGDV
LYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGD
HRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDAGYGE
LVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVEEADVFAIHHEGGVSCIQVF
FFRTGQNWGNRAYFPKADPQLSGAEVLNAFLAQFYDDKPVPKQIMLSETIEEMELLAAALSEKAGHKVAILVPRRGEKRD
LVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKS
TDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQATAADAADMPFPTWPDVILIDGGQGQMTAVRAILTELGITDSVTA
IGIAKGVDRDAGRERFFPPGRESFTLPPRDPVLYFVQRMRDEAHRFAIGSHRARRKKEMVKNPLDEIGGIGPSRKRALLQ
HFGTAKAVSRAALSDLMAVEGISEAVAKQVYNHFHDDAAK

Sequences:

>Translated_680_residues
MNGRKLPDGGVLYDDTDESEDEIEVEGDLSAAAPLATAVDWNAGSLNETGLIGAELIGEFVKRLPNSPGVYRMFNAEGDV
LYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGD
HRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDAGYGE
LVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVEEADVFAIHHEGGVSCIQVF
FFRTGQNWGNRAYFPKADPQLSGAEVLNAFLAQFYDDKPVPKQIMLSETIEEMELLAAALSEKAGHKVAILVPRRGEKRD
LVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKS
TDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQATAADAADMPFPTWPDVILIDGGQGQMTAVRAILTELGITDSVTA
IGIAKGVDRDAGRERFFPPGRESFTLPPRDPVLYFVQRMRDEAHRFAIGSHRARRKKEMVKNPLDEIGGIGPSRKRALLQ
HFGTAKAVSRAALSDLMAVEGISEAVAKQVYNHFHDDAAK
>Mature_680_residues
MNGRKLPDGGVLYDDTDESEDEIEVEGDLSAAAPLATAVDWNAGSLNETGLIGAELIGEFVKRLPNSPGVYRMFNAEGDV
LYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGD
HRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDAGYGE
LVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVEEADVFAIHHEGGVSCIQVF
FFRTGQNWGNRAYFPKADPQLSGAEVLNAFLAQFYDDKPVPKQIMLSETIEEMELLAAALSEKAGHKVAILVPRRGEKRD
LVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKS
TDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQATAADAADMPFPTWPDVILIDGGQGQMTAVRAILTELGITDSVTA
IGIAKGVDRDAGRERFFPPGRESFTLPPRDPVLYFVQRMRDEAHRFAIGSHRARRKKEMVKNPLDEIGGIGPSRKRALLQ
HFGTAKAVSRAALSDLMAVEGISEAVAKQVYNHFHDDAAK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=621, Percent_Identity=38.4863123993559, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1788037, Length=181, Percent_Identity=30.939226519337, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75037; Mature: 75037

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRKLPDGGVLYDDTDESEDEIEVEGDLSAAAPLATAVDWNAGSLNETGLIGAELIGEF
CCCCCCCCCCEEECCCCCCCCCEEECCCCCHHCCHHHEECCCCCCCCCCCCHHHHHHHHH
VKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVT
HHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHCCHHEHHHHHHHHHHHHHHHCCCEEEE
TRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYF
ECCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCC
GPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDAGYGE
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHH
LVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EEADVFAIHHEGGVSCIQVFFFRTGQNWGNRAYFPKADPQLSGAEVLNAFLAQFYDDKPV
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PKQIMLSETIEEMELLAAALSEKAGHKVAILVPRRGEKRDLVDHVVGNAREAHGRKLAET
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHH
ASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKS
HHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCCHHHHCCCEEECCCC
TDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQATAADAADMPFPTWPDVILIDGGQG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCC
QMTAVRAILTELGITDSVTAIGIAKGVDRDAGRERFFPPGRESFTLPPRDPVLYFVQRMR
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DEAHRFAIGSHRARRKKEMVKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVE
HHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
GISEAVAKQVYNHFHDDAAK
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNGRKLPDGGVLYDDTDESEDEIEVEGDLSAAAPLATAVDWNAGSLNETGLIGAELIGEF
CCCCCCCCCCEEECCCCCCCCCEEECCCCCHHCCHHHEECCCCCCCCCCCCHHHHHHHHH
VKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVT
HHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHCCHHEHHHHHHHHHHHHHHHCCCEEEE
TRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYF
ECCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCC
GPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDAGYGE
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHH
LVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EEADVFAIHHEGGVSCIQVFFFRTGQNWGNRAYFPKADPQLSGAEVLNAFLAQFYDDKPV
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PKQIMLSETIEEMELLAAALSEKAGHKVAILVPRRGEKRDLVDHVVGNAREAHGRKLAET
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHH
ASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKS
HHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCCHHHHCCCEEECCCC
TDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQATAADAADMPFPTWPDVILIDGGQG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCC
QMTAVRAILTELGITDSVTAIGIAKGVDRDAGRERFFPPGRESFTLPPRDPVLYFVQRMR
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DEAHRFAIGSHRARRKKEMVKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVE
HHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
GISEAVAKQVYNHFHDDAAK
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA