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The map label for this gene is livH [H]

Identifier: 209548685

GI number: 209548685

Start: 1101677

End: 1102573

Strand: Direct

Name: livH [H]

Synonym: Rleg2_1082

Alternate gene names: 209548685

Gene position: 1101677-1102573 (Clockwise)

Preceding gene: 209548682

Following gene: 209548691

Centisome position: 24.28

GC content: 64.1

Gene sequence:

>897_bases
ATGGCTTATCTTCTGCAGCAGCTGGCGAATGCGGTTCCGCTCGCCGCCCTTTATGCCGCACTCGCCTTTGGTTATGCCGT
CGCCTTCGGCGTGACGAAGCGGGCCGACATCACCTATGGGGCGATCTTCGCTTTTTCCGGCCAGATCCTGCTGCTGTTCA
CTGAGCTTGCCTTCAACCGCTTCTGGCTGGTGCTGCCGGCGGCCCTTGCCGTCGGCGCCTGCGCTGCCATCGCCTATTCG
CTGGCGGCGGGCCTATGGATCGGCCGTTCGATCATGCTGCCGCTGGTCAGCAAATCTCCGAATACGGTGATCGTCGCCGC
CCTCGGGATCATGATCGTGCTGATGGAAACCGCCCGGCTTGCCGCCAATACCCGCGCCATCTGGCTGCCGCCGTTTCTGA
ACGACACGGTCGTCTTCTGGAACGATGGCCCGTTCAAGGTGACGCTCACCTATATCCAGCTGATCGACACGGCGCTGATG
GCAGCCGTCGTCGCGATCGGGGCGCTGATCCTCAGGCGCACCGCCTGGGGCCGCATCTGGCGCGCCGTCACCGATGATCC
GTTGGCCGCCGAACTCTGCGGCACCAGCGCCGACCGCGTCTTTCTCGTCGCTTATGCGGCAGCTAGCCTCGTCGCCACGA
TCTGCGGCATCCTCGCGACATTCTATTACGGCTCGATGGATTTCGGCGCCGGCCTGATGTTCGGGCTGAAGGTGCTGCTG
ATTGCGGCTGTCGGCGGCTATTCCGATCCGCTGCGCTCGGCCGGCGGCGCTGCCTGCCTCGCCGTCGTCGAAACCCTATG
GGGCGCCTATGGCCCCTTCGTCTGGCGCGATTTCGTCATCTTTTCGCTGCTCGTTCTGCTCTTGGTCATGAGCCGCAGGG
AGCGGGTGGTGCTTTAG

Upstream 100 bases:

>100_bases
GCCGGCAAAGCGGTGAGGGGTCCAGGAAAAGCTCATGATGAAATTATAACTGGTGAAATGAATTTTACCAGTTATAATTT
GACGACGCGGAGTGCATGGA

Downstream 100 bases:

>100_bases
CCTATTTCCACTTGTCGCGCGCCGCGTCGTCGGCGTCTTTCGCCGCGACCCAGTCGCCCTCGGCGCCATCCCGACTGTGC
TCCTTCTTCCAGAAGGGGGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAYLLQQLANAVPLAALYAALAFGYAVAFGVTKRADITYGAIFAFSGQILLLFTELAFNRFWLVLPAALAVGACAAIAYS
LAAGLWIGRSIMLPLVSKSPNTVIVAALGIMIVLMETARLAANTRAIWLPPFLNDTVVFWNDGPFKVTLTYIQLIDTALM
AAVVAIGALILRRTAWGRIWRAVTDDPLAAELCGTSADRVFLVAYAAASLVATICGILATFYYGSMDFGAGLMFGLKVLL
IAAVGGYSDPLRSAGGAACLAVVETLWGAYGPFVWRDFVIFSLLVLLLVMSRRERVVL

Sequences:

>Translated_298_residues
MAYLLQQLANAVPLAALYAALAFGYAVAFGVTKRADITYGAIFAFSGQILLLFTELAFNRFWLVLPAALAVGACAAIAYS
LAAGLWIGRSIMLPLVSKSPNTVIVAALGIMIVLMETARLAANTRAIWLPPFLNDTVVFWNDGPFKVTLTYIQLIDTALM
AAVVAIGALILRRTAWGRIWRAVTDDPLAAELCGTSADRVFLVAYAAASLVATICGILATFYYGSMDFGAGLMFGLKVLL
IAAVGGYSDPLRSAGGAACLAVVETLWGAYGPFVWRDFVIFSLLVLLLVMSRRERVVL
>Mature_297_residues
AYLLQQLANAVPLAALYAALAFGYAVAFGVTKRADITYGAIFAFSGQILLLFTELAFNRFWLVLPAALAVGACAAIAYSL
AAGLWIGRSIMLPLVSKSPNTVIVAALGIMIVLMETARLAANTRAIWLPPFLNDTVVFWNDGPFKVTLTYIQLIDTALMA
AVVAIGALILRRTAWGRIWRAVTDDPLAAELCGTSADRVFLVAYAAASLVATICGILATFYYGSMDFGAGLMFGLKVLLI
AAVGGYSDPLRSAGGAACLAVVETLWGAYGPFVWRDFVIFSLLVLLLVMSRRERVVL

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=292, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31847; Mature: 31716

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYLLQQLANAVPLAALYAALAFGYAVAFGVTKRADITYGAIFAFSGQILLLFTELAFNR
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHH
FWLVLPAALAVGACAAIAYSLAAGLWIGRSIMLPLVSKSPNTVIVAALGIMIVLMETARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
AANTRAIWLPPFLNDTVVFWNDGPFKVTLTYIQLIDTALMAAVVAIGALILRRTAWGRIW
HHCCCEEEECCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVTDDPLAAELCGTSADRVFLVAYAAASLVATICGILATFYYGSMDFGAGLMFGLKVLL
HHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IAAVGGYSDPLRSAGGAACLAVVETLWGAYGPFVWRDFVIFSLLVLLLVMSRRERVVL
HHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AYLLQQLANAVPLAALYAALAFGYAVAFGVTKRADITYGAIFAFSGQILLLFTELAFNR
HHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHH
FWLVLPAALAVGACAAIAYSLAAGLWIGRSIMLPLVSKSPNTVIVAALGIMIVLMETARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
AANTRAIWLPPFLNDTVVFWNDGPFKVTLTYIQLIDTALMAAVVAIGALILRRTAWGRIW
HHCCCEEEECCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVTDDPLAAELCGTSADRVFLVAYAAASLVATICGILATFYYGSMDFGAGLMFGLKVLL
HHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IAAVGGYSDPLRSAGGAACLAVVETLWGAYGPFVWRDFVIFSLLVLLLVMSRRERVVL
HHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]