Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 209548682

GI number: 209548682

Start: 1100056

End: 1100478

Strand: Direct

Name: ndk [H]

Synonym: Rleg2_1079

Alternate gene names: 209548682

Gene position: 1100056-1100478 (Clockwise)

Preceding gene: 209548681

Following gene: 209548685

Centisome position: 24.24

GC content: 60.28

Gene sequence:

>423_bases
ATGGCGATTGAACGCACCTTCTCGATGATCAAGCCGGATGCAACTAAGCGTAACCTGACGGGCGCCATCACCAAGATGCT
CGAAGATGCCGGCCTGCGCGTCGTCGCCTCCAAGCGCGTCTGGATGAGCCGCCGCGAAGCTGAAGGCTTCTACGCCGTTC
ACAAGGATCGCCCCTTCTTCGGCGAACTCGTCGAAGGCATGACCTCCGGCCCGACCGTCGTTCAGGTTCTGGAAGGCGAA
GGCGCCATCCTCAAGAACCGCGAGATCATGGGCGCGACCAACCCGGCAAACGCTGACGAAGGCACGATCCGTAAGGTTCA
CGCTCTGTCGATCGGCGAAAATTCCGTTCACGGCTCCGATGCTCCGGAGACGGCTGCCCAGGAAATCAAGTACTGGTTCT
CCGATACCGAAGTCGTCGGCTGA

Upstream 100 bases:

>100_bases
GACTGTGACAGCGGCGTGAAATTGCCGCCGACCTCTTGTTTTCGGGCGGTGGGGCGGGTAAAGACCGCCCACTTTTCCCG
AGAAAACAGAGGATTTGACT

Downstream 100 bases:

>100_bases
GACCACGCTTCGGCATTGGTTCGCAATGCCTTGAATTGACTCTCGAAAGCCGGGGCTTCGCTCCGGCTTTTCTATGCCCG
GACGTTCATCATGCCGGGCA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEGMTSGPTVVQVLEGE
GAILKNREIMGATNPANADEGTIRKVHALSIGENSVHGSDAPETAAQEIKYWFSDTEVVG

Sequences:

>Translated_140_residues
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEGMTSGPTVVQVLEGE
GAILKNREIMGATNPANADEGTIRKVHALSIGENSVHGSDAPETAAQEIKYWFSDTEVVG
>Mature_139_residues
AIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEGMTSGPTVVQVLEGEG
AILKNREIMGATNPANADEGTIRKVHALSIGENSVHGSDAPETAAQEIKYWFSDTEVVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=42.7536231884058, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.7956204379562, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.7956204379562, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=34.5588235294118, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=32.3308270676692, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=32.3308270676692, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=31.1594202898551, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=53.2374100719424, Blast_Score=153, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=40.4411764705882, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=45.5882352941176, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=30.1470588235294, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15296; Mature: 15164

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFF
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCEEEEECCCCHH
GELVEGMTSGPTVVQVLEGEGAILKNREIMGATNPANADEGTIRKVHALSIGENSVHGSD
HHHHHCCCCCCEEEEEECCCCCEEECCEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCC
APETAAQEIKYWFSDTEVVG
CCHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
AIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFF
CCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCEEEEECCCCHH
GELVEGMTSGPTVVQVLEGEGAILKNREIMGATNPANADEGTIRKVHALSIGENSVHGSD
HHHHHCCCCCCEEEEEECCCCCEEECCEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCC
APETAAQEIKYWFSDTEVVG
CCHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]