Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 209548665

GI number: 209548665

Start: 1080065

End: 1080727

Strand: Direct

Name: gmk [H]

Synonym: Rleg2_1062

Alternate gene names: 209548665

Gene position: 1080065-1080727 (Clockwise)

Preceding gene: 209548664

Following gene: 209548673

Centisome position: 23.8

GC content: 64.71

Gene sequence:

>663_bases
ATGAATCCGGCGAAATCCTCGCCCGTCCAGATCGCCCGCCGCGGTCTGATGCTTGTCATTTCGTCGCCGTCGGGCGCCGG
CAAGTCCACCATCGCGCGCACGCTGCTGGAGAAGGACAGGCAAATCGGCCTCTCCGTCAGCGTCACCACGCGCCAGCGCC
GCCCGAGCGAAATCGAGGATGTGCATTACCACTTCAAGAGCGTGCGCGAGTTCGAGCGGATGCGCGACAGCGACGCGCTG
CTCGAATGGGCCGAAGTGCATGGCAATTTCTACGGCACGCCGCGCGAGCCTGTGGAGCAGGCCATGGCCGAGGGCCGCGA
CATGCTCTTCGATATCGACTGGCAGGGCGCCCAGCAATTGCAGGAAAAGATGTCGGCCGACGTCGTTTCGATCTTCGTGC
TGCCGCCGACCATGACCGAGCTGCAGTCGCGGCTGCACCGCCGCGCCGAGGATTCCGAGGATGTCATCCAGACGCGCCTG
GCCAACAGCCGCGCCGAGATCGCCCACTGGCGCGAATATGACTATGTCATCGTCAACGACGACCTCAACGCCGCCTTCGA
CGCCGTCCAGTCGATCGTCAAGGCCGAACGCTTGCGCCGCGACCGCCGCCACGGCATGTTCGATTTCGTCCGCGAGCTGC
TGGAAGAGACGCCGTCGCTTTAG

Upstream 100 bases:

>100_bases
CTGCTCGAAGTCGAATGCCTCGGCGGTGACCGCCGCCGGCATCGAGCTGAAAGTTGTGATCGACCAGTTCCGCGAGCAGG
TCCAGAATTTGGAGTAGGAC

Downstream 100 bases:

>100_bases
AGGCTGTTTGCGAGAAGGCAGAATTCCTCGACTGACAAGGTCTCCGCCCGGCGCGCCGGATCGATCCCGGCCTTGACGAG
AAGCCTCTCGCCGCCAAGCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MNPAKSSPVQIARRGLMLVISSPSGAGKSTIARTLLEKDRQIGLSVSVTTRQRRPSEIEDVHYHFKSVREFERMRDSDAL
LEWAEVHGNFYGTPREPVEQAMAEGRDMLFDIDWQGAQQLQEKMSADVVSIFVLPPTMTELQSRLHRRAEDSEDVIQTRL
ANSRAEIAHWREYDYVIVNDDLNAAFDAVQSIVKAERLRRDRRHGMFDFVRELLEETPSL

Sequences:

>Translated_220_residues
MNPAKSSPVQIARRGLMLVISSPSGAGKSTIARTLLEKDRQIGLSVSVTTRQRRPSEIEDVHYHFKSVREFERMRDSDAL
LEWAEVHGNFYGTPREPVEQAMAEGRDMLFDIDWQGAQQLQEKMSADVVSIFVLPPTMTELQSRLHRRAEDSEDVIQTRL
ANSRAEIAHWREYDYVIVNDDLNAAFDAVQSIVKAERLRRDRRHGMFDFVRELLEETPSL
>Mature_220_residues
MNPAKSSPVQIARRGLMLVISSPSGAGKSTIARTLLEKDRQIGLSVSVTTRQRRPSEIEDVHYHFKSVREFERMRDSDAL
LEWAEVHGNFYGTPREPVEQAMAEGRDMLFDIDWQGAQQLQEKMSADVVSIFVLPPTMTELQSRLHRRAEDSEDVIQTRL
ANSRAEIAHWREYDYVIVNDDLNAAFDAVQSIVKAERLRRDRRHGMFDFVRELLEETPSL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=34.020618556701, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=34.020618556701, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=34.020618556701, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI14780902, Length=192, Percent_Identity=28.6458333333333, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21361598, Length=205, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21536464, Length=194, Percent_Identity=28.8659793814433, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=26.1111111111111, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=50, Blast_Score=191, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=37.1584699453552, Blast_Score=133, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=32.6424870466321, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25312; Mature: 25312

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPAKSSPVQIARRGLMLVISSPSGAGKSTIARTLLEKDRQIGLSVSVTTRQRRPSEIED
CCCCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
VHYHFKSVREFERMRDSDALLEWAEVHGNFYGTPREPVEQAMAEGRDMLFDIDWQGAQQL
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHH
QEKMSADVVSIFVLPPTMTELQSRLHRRAEDSEDVIQTRLANSRAEIAHWREYDYVIVND
HHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCEEEECC
DLNAAFDAVQSIVKAERLRRDRRHGMFDFVRELLEETPSL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNPAKSSPVQIARRGLMLVISSPSGAGKSTIARTLLEKDRQIGLSVSVTTRQRRPSEIED
CCCCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
VHYHFKSVREFERMRDSDALLEWAEVHGNFYGTPREPVEQAMAEGRDMLFDIDWQGAQQL
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHH
QEKMSADVVSIFVLPPTMTELQSRLHRRAEDSEDVIQTRLANSRAEIAHWREYDYVIVND
HHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCEEEECC
DLNAAFDAVQSIVKAERLRRDRRHGMFDFVRELLEETPSL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA