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The map label for this gene is phoQ [H]

Identifier: 209548521

GI number: 209548521

Start: 931576

End: 932979

Strand: Direct

Name: phoQ [H]

Synonym: Rleg2_0918

Alternate gene names: 209548521

Gene position: 931576-932979 (Clockwise)

Preceding gene: 209548520

Following gene: 209548522

Centisome position: 20.53

GC content: 65.17

Gene sequence:

>1404_bases
ATGCGAATTAAGTCGCTCACCGCACGTGTCTTGCTGTTGACCACGGTGTGGTCGACGGTGGCGCTTGTCGTGATCGGCCT
GTTGATCTCCACCCTCTACCGCAAGAGCGCCGAGCGTGGTTTCCAGGATCTGTTGCGGGCACAGCTCTATAACGTCATCA
ACTCGGTGACCATCGGTGATCAGGGCGCGCTCAGCGGCAGCCCGCAGCTTGGCGACCTGCGTTTTGCCCAGCCGAAGACC
GGCTGGTACTGGGTGGTCGAGCCGCTCGGCACCTATACGACAGCGCCGCTGGTGTCGCCCTCGCTCGGCTCGGCGCTCAT
TCCGGTACCCTCCGTCGTCGAGGCGCCCTTCGACAAGAATTACGAGCGCTACTACCAGGTGACGGATGCCTCCGGGAACC
GCGTGCAGGTGGCCGAAACCGAAGTGGTGCTCGATACCGACGGGCGCGCGGCGCGCGTCCGCGTCACCGGCAATGTCGAT
GTCGTCGAGGACGATGTGCGCACTTTTTCCCATAGCCTTTATCTGGCGCTCGCCGGCTTCGGCGTCGGCAGCCTGATCGT
CAATGCGCTGGCGATTCTCTATGGCCTGAAGCCGCTCGACAAGGCGCGTGCCGCCTTGGAGCGCATCCGCGCCGGCGAGA
GCGAGCAGCTGAAGGGCGACTTCCCGCGCGAGATTTTGCCGCTTGCCAATGAGGTCAACGCGCTGATCGACAGCAACCGC
CGCATCGTCGAGCGGGCCCGCATGCAGGTCGGCAATCTCGCCCATTCGCTGAAGACGCCGATCGCCGTTCTGCTGAACGA
AGCGCGCGTGCTCGAAAAATCCCATGGCGAACTGGTGCGCAGCCAGGCGGAATCGATGCAGGGGCAGGTGCAGTCTTATC
TCAACCGGGCCCGCATCGCTGCGCAGCGCGAATCCGTGCTCGCCCGCACCGATGCCGAGCCGGCGCTCGAGCGCCTGGTG
CGCGTCATGCGCCGGCTGAACGTCGATACCGAATTCGATCTCGTCGTCTCGCCGCCGCATCTGGCCGTCGCCATGGAGCA
GCAGGATCTCGAGGAGACCGTCGGCAATCTCTTGGAGAATGCGGCGCGTTTTGCCAGGAGCAAAGTCCGGCTTTCGGCCG
TCGAGGCCGGCGACGACGTCAGGGGCGCGGAGGCGAGCGCGCGCCGCCACTGGGTGGAACTCGCGGTCGAGGATGACGGG
CCGGGACTGGAGCCTGACCAGATCCGCGAGGCGCTGAAACGCGGCCGCAGGCTGGACGAAAGCAAGCCCGGAACCGGGCT
GGGCCTGTCGATCGTCACCGAGATTTCCAGTGAGTATCAGGGGCGGCTCGAGCTTTCCCGCGGCGAATGGGGCGGGCTCA
AGGCGAAGCTTATCCTGCCCGGCATCACAAAGGATGTTGCATGA

Upstream 100 bases:

>100_bases
AACACGATCGAGGTCTTTGTCGGCCGTTTGCGCAAGAAAATGGGCGTCGATCTGATCGAAACGGTGCGCGGTCTCGGTTA
CCGCATCCAAGCGCCGAAAC

Downstream 100 bases:

>100_bases
GCAACTGCTTGATGTCACAAAGATACTGGCAAATGTATAGCATGCTTTGCCTTAATGCTGACACGGGGACGCTGCACTTC
GATCGGCTGAAATTGACCCC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRIKSLTARVLLLTTVWSTVALVVIGLLISTLYRKSAERGFQDLLRAQLYNVINSVTIGDQGALSGSPQLGDLRFAQPKT
GWYWVVEPLGTYTTAPLVSPSLGSALIPVPSVVEAPFDKNYERYYQVTDASGNRVQVAETEVVLDTDGRAARVRVTGNVD
VVEDDVRTFSHSLYLALAGFGVGSLIVNALAILYGLKPLDKARAALERIRAGESEQLKGDFPREILPLANEVNALIDSNR
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEKSHGELVRSQAESMQGQVQSYLNRARIAAQRESVLARTDAEPALERLV
RVMRRLNVDTEFDLVVSPPHLAVAMEQQDLEETVGNLLENAARFARSKVRLSAVEAGDDVRGAEASARRHWVELAVEDDG
PGLEPDQIREALKRGRRLDESKPGTGLGLSIVTEISSEYQGRLELSRGEWGGLKAKLILPGITKDVA

Sequences:

>Translated_467_residues
MRIKSLTARVLLLTTVWSTVALVVIGLLISTLYRKSAERGFQDLLRAQLYNVINSVTIGDQGALSGSPQLGDLRFAQPKT
GWYWVVEPLGTYTTAPLVSPSLGSALIPVPSVVEAPFDKNYERYYQVTDASGNRVQVAETEVVLDTDGRAARVRVTGNVD
VVEDDVRTFSHSLYLALAGFGVGSLIVNALAILYGLKPLDKARAALERIRAGESEQLKGDFPREILPLANEVNALIDSNR
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEKSHGELVRSQAESMQGQVQSYLNRARIAAQRESVLARTDAEPALERLV
RVMRRLNVDTEFDLVVSPPHLAVAMEQQDLEETVGNLLENAARFARSKVRLSAVEAGDDVRGAEASARRHWVELAVEDDG
PGLEPDQIREALKRGRRLDESKPGTGLGLSIVTEISSEYQGRLELSRGEWGGLKAKLILPGITKDVA
>Mature_467_residues
MRIKSLTARVLLLTTVWSTVALVVIGLLISTLYRKSAERGFQDLLRAQLYNVINSVTIGDQGALSGSPQLGDLRFAQPKT
GWYWVVEPLGTYTTAPLVSPSLGSALIPVPSVVEAPFDKNYERYYQVTDASGNRVQVAETEVVLDTDGRAARVRVTGNVD
VVEDDVRTFSHSLYLALAGFGVGSLIVNALAILYGLKPLDKARAALERIRAGESEQLKGDFPREILPLANEVNALIDSNR
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEKSHGELVRSQAESMQGQVQSYLNRARIAAQRESVLARTDAEPALERLV
RVMRRLNVDTEFDLVVSPPHLAVAMEQQDLEETVGNLLENAARFARSKVRLSAVEAGDDVRGAEASARRHWVELAVEDDG
PGLEPDQIREALKRGRRLDESKPGTGLGLSIVTEISSEYQGRLELSRGEWGGLKAKLILPGITKDVA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=282, Percent_Identity=28.7234042553192, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789808, Length=242, Percent_Identity=24.3801652892562, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=24.8201438848921, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787894, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=29.3577981651376, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=26.2008733624454, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51137; Mature: 51137

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKSLTARVLLLTTVWSTVALVVIGLLISTLYRKSAERGFQDLLRAQLYNVINSVTIGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QGALSGSPQLGDLRFAQPKTGWYWVVEPLGTYTTAPLVSPSLGSALIPVPSVVEAPFDKN
CCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
YERYYQVTDASGNRVQVAETEVVLDTDGRAARVRVTGNVDVVEDDVRTFSHSLYLALAGF
CHHEEEEECCCCCEEEEEEEEEEEECCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHC
GVGSLIVNALAILYGLKPLDKARAALERIRAGESEQLKGDFPREILPLANEVNALIDSNR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCH
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEKSHGELVRSQAESMQGQVQSYLNRARIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRESVLARTDAEPALERLVRVMRRLNVDTEFDLVVSPPHLAVAMEQQDLEETVGNLLEN
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHH
AARFARSKVRLSAVEAGDDVRGAEASARRHWVELAVEDDGPGLEPDQIREALKRGRRLDE
HHHHHHHHHHHEEECCCCCCCCCHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHCCCCCC
SKPGTGLGLSIVTEISSEYQGRLELSRGEWGGLKAKLILPGITKDVA
CCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCHHHCCC
>Mature Secondary Structure
MRIKSLTARVLLLTTVWSTVALVVIGLLISTLYRKSAERGFQDLLRAQLYNVINSVTIGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QGALSGSPQLGDLRFAQPKTGWYWVVEPLGTYTTAPLVSPSLGSALIPVPSVVEAPFDKN
CCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
YERYYQVTDASGNRVQVAETEVVLDTDGRAARVRVTGNVDVVEDDVRTFSHSLYLALAGF
CHHEEEEECCCCCEEEEEEEEEEEECCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHC
GVGSLIVNALAILYGLKPLDKARAALERIRAGESEQLKGDFPREILPLANEVNALIDSNR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCH
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEKSHGELVRSQAESMQGQVQSYLNRARIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRESVLARTDAEPALERLVRVMRRLNVDTEFDLVVSPPHLAVAMEQQDLEETVGNLLEN
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHH
AARFARSKVRLSAVEAGDDVRGAEASARRHWVELAVEDDGPGLEPDQIREALKRGRRLDE
HHHHHHHHHHHEEECCCCCCCCCHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHCCCCCC
SKPGTGLGLSIVTEISSEYQGRLELSRGEWGGLKAKLILPGITKDVA
CCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA