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The map label for this gene is phoP [H]

Identifier: 209548520

GI number: 209548520

Start: 930915

End: 931586

Strand: Direct

Name: phoP [H]

Synonym: Rleg2_0917

Alternate gene names: 209548520

Gene position: 930915-931586 (Clockwise)

Preceding gene: 209548519

Following gene: 209548521

Centisome position: 20.51

GC content: 60.42

Gene sequence:

>672_bases
ATGCGTATTCTGGTAGTCGAAGACGACGTCAATTTGAACCGGCAGCTGGCCGACACGCTGAAGGAGGCGGGCTATGTCGT
CGACCAGGCGTTCGACGGCGAGGAAGGCCATTTCCTCGGCGATACCGAACCCTATGACGCCATCATTCTCGACATTGGCC
TGCCGGATCTGGATGGAGTGACCGTTCTTGAAAAATGGCGCGGCGCCGGCCGCGGTGTGCCGGTGCTGATTCTGACGGCG
CGCGACCGCTGGAGCGACAAGGTCGCCGGTATCGACGCAGGCGCCGACGACTACGTCACCAAGCCCTTCCATGTCGAGGA
AGTGCTGGCGCGCATTCGGGCGCTGATCCGCCGTGCGGCCGGGCATTCCTCATCCGAGATCATCTGCGGGCCGGTGCGGC
TCGATACAAAATCCTCGAAGGCGACGGTCAACGGCACGACGCTGAAGCTGACCTCGCACGAATACCGCCTGCTTGCCTAT
CTAATGCATCACATGGGCGAGGTCGTCTCGCGCACCGAACTGGTCGAGCACATGTACGATCAGGATTTCGACCGCGATTC
CAACACGATCGAGGTCTTTGTCGGCCGTTTGCGCAAGAAAATGGGCGTCGATCTGATCGAAACGGTGCGCGGTCTCGGTT
ACCGCATCCAAGCGCCGAAACATGCGAATTAA

Upstream 100 bases:

>100_bases
GCAACGGCCAGCGTCCACGCAAGGTGACGGTAAAGGTTCCGATGTAGGCGGAATCGGTCTATTCAGGACAGATCGATTTG
AAGCGGACGAAGGCGGACCG

Downstream 100 bases:

>100_bases
GTCGCTCACCGCACGTGTCTTGCTGTTGACCACGGTGTGGTCGACGGTGGCGCTTGTCGTGATCGGCCTGTTGATCTCCA
CCCTCTACCGCAAGAGCGCC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILVVEDDVNLNRQLADTLKEAGYVVDQAFDGEEGHFLGDTEPYDAIILDIGLPDLDGVTVLEKWRGAGRGVPVLILTA
RDRWSDKVAGIDAGADDYVTKPFHVEEVLARIRALIRRAAGHSSSEIICGPVRLDTKSSKATVNGTTLKLTSHEYRLLAY
LMHHMGEVVSRTELVEHMYDQDFDRDSNTIEVFVGRLRKKMGVDLIETVRGLGYRIQAPKHAN

Sequences:

>Translated_223_residues
MRILVVEDDVNLNRQLADTLKEAGYVVDQAFDGEEGHFLGDTEPYDAIILDIGLPDLDGVTVLEKWRGAGRGVPVLILTA
RDRWSDKVAGIDAGADDYVTKPFHVEEVLARIRALIRRAAGHSSSEIICGPVRLDTKSSKATVNGTTLKLTSHEYRLLAY
LMHHMGEVVSRTELVEHMYDQDFDRDSNTIEVFVGRLRKKMGVDLIETVRGLGYRIQAPKHAN
>Mature_223_residues
MRILVVEDDVNLNRQLADTLKEAGYVVDQAFDGEEGHFLGDTEPYDAIILDIGLPDLDGVTVLEKWRGAGRGVPVLILTA
RDRWSDKVAGIDAGADDYVTKPFHVEEVLARIRALIRRAAGHSSSEIICGPVRLDTKSSKATVNGTTLKLTSHEYRLLAY
LMHHMGEVVSRTELVEHMYDQDFDRDSNTIEVFVGRLRKKMGVDLIETVRGLGYRIQAPKHAN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=43.1192660550459, Blast_Score=185, Evalue=2e-48,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=43.3035714285714, Blast_Score=177, Evalue=4e-46,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=43.9814814814815, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=39.7321428571429, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=42.2018348623853, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.4821428571429, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=33.4841628959276, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.070796460177, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.7017543859649, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.4642857142857, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=25.3275109170306, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24883; Mature: 24883

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDDVNLNRQLADTLKEAGYVVDQAFDGEEGHFLGDTEPYDAIILDIGLPDLDGV
CEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCH
TVLEKWRGAGRGVPVLILTARDRWSDKVAGIDAGADDYVTKPFHVEEVLARIRALIRRAA
HHHHHHCCCCCCCCEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GHSSSEIICGPVRLDTKSSKATVNGTTLKLTSHEYRLLAYLMHHMGEVVSRTELVEHMYD
CCCCCCEEEECEEECCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKMGVDLIETVRGLGYRIQAPKHAN
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MRILVVEDDVNLNRQLADTLKEAGYVVDQAFDGEEGHFLGDTEPYDAIILDIGLPDLDGV
CEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCH
TVLEKWRGAGRGVPVLILTARDRWSDKVAGIDAGADDYVTKPFHVEEVLARIRALIRRAA
HHHHHHCCCCCCCCEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GHSSSEIICGPVRLDTKSSKATVNGTTLKLTSHEYRLLAYLMHHMGEVVSRTELVEHMYD
CCCCCCEEEECEEECCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKMGVDLIETVRGLGYRIQAPKHAN
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA