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The map label for this gene is barA [C]

Identifier: 209548487

GI number: 209548487

Start: 901057

End: 902598

Strand: Direct

Name: barA [C]

Synonym: Rleg2_0884

Alternate gene names: 209548487

Gene position: 901057-902598 (Clockwise)

Preceding gene: 209548484

Following gene: 209548488

Centisome position: 19.86

GC content: 65.24

Gene sequence:

>1542_bases
GTGCGAGTATTGAGTAACATTGGCGGCTGGGTGACGGCGCTCGTAGACCGGGCGGCGACAAGCTGGCTCTCCCGGACGGG
CGGCGGTGAAGCTGTGCGCCAGCGCGAGCTTGCGATCCTGCGCCGCCTCGTGCTGTTCTCGTCGGCTGCTCTTATTGCCG
CTCCCATCGGCCTTTCGGCGGTCACCAGCCCGGCCGTCGCCTTGCCGGCAGGGGTCGCCATGGTCTGCGCCGCCTTTCTT
TTCTCCGCCGTCGGCAGCATCGCGCTTGCTCGTCAGGGTTCGTCCGCCGGGATCGCGACACAGACGGCCGAGGATTTCTT
CCTTGACGCCACCCCCGGCCTCGTCTTCTTCCTCGATCCGCATGGCAGTGTGGCGACGATCGGCGGCCGCGACCGGCGCG
ATTTTCTCGCCTGGATGCGCGATCCCAAGGGCAGGGGCTTCCTGGAGCAGGTGCACGTCTCCGACCGCATCCTTTTCCTG
CAGGCGCTCGATAGCCTGCGCCGAGGCGAGGATGCCGAGTGCGTCGATCTGCGCATCGACCGCCCCTCGGTCGCGCGCGA
TCAACGCCAGTTCGCCTATCTCAGAATGGACATGACGGCCCGGCGCGACGCCGACGGCGAACTTGCCGCCGTCATTGCCC
AGCTGCGCGATGTCTCCGTCGAGCAGCAGCTGCGGGCCGAAGCCCAGAACCGCGTCGCCGATGCCGAATCGGCAAACGAT
GCCAAGTCGCGCTTCCTCGCCGCCGTCAGCCACGAGCTGCGCACGCCGCTGAATGCCATTCTCGGTTTTTCCGATATCCT
GATCGGCGAATATTTCGGCAAGTTCGAAAACGACCGCCAGCGCGAATATGTCAGCCTCGTGCGCGAATCCGGCGCCCATC
TCCTGTCCGTCGTCAACACCATGCTCGACATGAGCAAGATCGAAGCCGGCCGCTACGAGTTGATCCTCGAACCTTTCGAC
ATAGCGAGCTCAGTCAAATCCTGCGAATCGATGCTGGCCTTGCAGGCCAAGACCAAGGGCCTGACGCTGACGAGCCGGAT
CCAGCGCGGCCTCGGCGAAATCGTCGCCGATCAGCGCGCCATCCAGCAGATCCTCATCAATCTCGTCGGCAATGCGATAA
AGTTCACCGAGGCCGGCGGCGTCGTCTCGGTCGATGCGGCGGCGCGCGACGGCATCCTCAAGCTGACGGTCAGCGATACC
GGCATCGGTATTGCAGCCGACAAGCTGGCACTGCTCGGCCAGCCCTTCGTCCAGATCCAGAACGACTATACCCGCCGCTT
CGAAGGCACCGGCCTTGGTCTCTCCCTGGTCAAGGGGCTGGTGGCGCTGCATGGCGGGCATTTCGCCATCGCCAGCCAGC
CCGGCGAAGGCACGATCATCACCATCGAGATCGCGGTGGACGGCTCGGGCGCGGTATGCGCCGAAGACGCCGGCCAGGGC
GCGACTGTAGAGTTCCCGCCGCGGCTGAAGGGCGCGGTCAATGCAGGTGCAGAATTGGGGGAGGGGCGTTTCGATGGCCG
CGCGCAAGCGAAAATCGCCTAA

Upstream 100 bases:

>100_bases
GGCCTTTCCGGCTGTGAACAGCGCTTTTGCCTTATCCTTTCTTTAAGCCGCCGGGGCCTATTGTCCGGATCGATAGACAG
CCTTTTTGGGCGGGTATTGC

Downstream 100 bases:

>100_bases
GGGAAAAAGGGGACGGCAGCAGCCGGGCCTCTTGATGTCGGGTGCAGCGGCCCTCGGCGGCCTCAGCCTGCAGGGCGCCT
CGGTGCTCGGCGGCGTCATC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRVLSNIGGWVTALVDRAATSWLSRTGGGEAVRQRELAILRRLVLFSSAALIAAPIGLSAVTSPAVALPAGVAMVCAAFL
FSAVGSIALARQGSSAGIATQTAEDFFLDATPGLVFFLDPHGSVATIGGRDRRDFLAWMRDPKGRGFLEQVHVSDRILFL
QALDSLRRGEDAECVDLRIDRPSVARDQRQFAYLRMDMTARRDADGELAAVIAQLRDVSVEQQLRAEAQNRVADAESAND
AKSRFLAAVSHELRTPLNAILGFSDILIGEYFGKFENDRQREYVSLVRESGAHLLSVVNTMLDMSKIEAGRYELILEPFD
IASSVKSCESMLALQAKTKGLTLTSRIQRGLGEIVADQRAIQQILINLVGNAIKFTEAGGVVSVDAAARDGILKLTVSDT
GIGIAADKLALLGQPFVQIQNDYTRRFEGTGLGLSLVKGLVALHGGHFAIASQPGEGTIITIEIAVDGSGAVCAEDAGQG
ATVEFPPRLKGAVNAGAELGEGRFDGRAQAKIA

Sequences:

>Translated_513_residues
MRVLSNIGGWVTALVDRAATSWLSRTGGGEAVRQRELAILRRLVLFSSAALIAAPIGLSAVTSPAVALPAGVAMVCAAFL
FSAVGSIALARQGSSAGIATQTAEDFFLDATPGLVFFLDPHGSVATIGGRDRRDFLAWMRDPKGRGFLEQVHVSDRILFL
QALDSLRRGEDAECVDLRIDRPSVARDQRQFAYLRMDMTARRDADGELAAVIAQLRDVSVEQQLRAEAQNRVADAESAND
AKSRFLAAVSHELRTPLNAILGFSDILIGEYFGKFENDRQREYVSLVRESGAHLLSVVNTMLDMSKIEAGRYELILEPFD
IASSVKSCESMLALQAKTKGLTLTSRIQRGLGEIVADQRAIQQILINLVGNAIKFTEAGGVVSVDAAARDGILKLTVSDT
GIGIAADKLALLGQPFVQIQNDYTRRFEGTGLGLSLVKGLVALHGGHFAIASQPGEGTIITIEIAVDGSGAVCAEDAGQG
ATVEFPPRLKGAVNAGAELGEGRFDGRAQAKIA
>Mature_513_residues
MRVLSNIGGWVTALVDRAATSWLSRTGGGEAVRQRELAILRRLVLFSSAALIAAPIGLSAVTSPAVALPAGVAMVCAAFL
FSAVGSIALARQGSSAGIATQTAEDFFLDATPGLVFFLDPHGSVATIGGRDRRDFLAWMRDPKGRGFLEQVHVSDRILFL
QALDSLRRGEDAECVDLRIDRPSVARDQRQFAYLRMDMTARRDADGELAAVIAQLRDVSVEQQLRAEAQNRVADAESAND
AKSRFLAAVSHELRTPLNAILGFSDILIGEYFGKFENDRQREYVSLVRESGAHLLSVVNTMLDMSKIEAGRYELILEPFD
IASSVKSCESMLALQAKTKGLTLTSRIQRGLGEIVADQRAIQQILINLVGNAIKFTEAGGVVSVDAAARDGILKLTVSDT
GIGIAADKLALLGQPFVQIQNDYTRRFEGTGLGLSLVKGLVALHGGHFAIASQPGEGTIITIEIAVDGSGAVCAEDAGQG
ATVEFPPRLKGAVNAGAELGEGRFDGRAQAKIA

Specific function: Member Of The Two-Component Regulatory System Uvry/Bara Involved In The Regulation Of Carbon Metabolism Via The Csra/Csrb Regulatory System. Phosphorylates Uvry, Probably Via A Four-Step Phosphorelay. [C]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=279, Percent_Identity=36.2007168458781, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=35.5805243445693, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788713, Length=288, Percent_Identity=32.2916666666667, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=33.0543933054393, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87081816, Length=276, Percent_Identity=31.8840579710145, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=30.9417040358744, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=28.6324786324786, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=385, Percent_Identity=25.1948051948052, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=243, Percent_Identity=27.1604938271605, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=28.8065843621399, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=23.7668161434978, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=24.3589743589744, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=25.2212389380531, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=26.0663507109005, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54614; Mature: 54614

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLSNIGGWVTALVDRAATSWLSRTGGGEAVRQRELAILRRLVLFSSAALIAAPIGLSA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHH
VTSPAVALPAGVAMVCAAFLFSAVGSIALARQGSSAGIATQTAEDFFLDATPGLVFFLDP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHEEECCCCEEEEECC
HGSVATIGGRDRRDFLAWMRDPKGRGFLEQVHVSDRILFLQALDSLRRGEDAECVDLRID
CCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
RPSVARDQRQFAYLRMDMTARRDADGELAAVIAQLRDVSVEQQLRAEAQNRVADAESAND
CCCHHHHHHHHHHHEECHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCH
AKSRFLAAVSHELRTPLNAILGFSDILIGEYFGKFENDRQREYVSLVRESGAHLLSVVNT
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
MLDMSKIEAGRYELILEPFDIASSVKSCESMLALQAKTKGLTLTSRIQRGLGEIVADQRA
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IQQILINLVGNAIKFTEAGGVVSVDAAARDGILKLTVSDTGIGIAADKLALLGQPFVQIQ
HHHHHHHHHCCCEEEECCCCEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHC
NDYTRRFEGTGLGLSLVKGLVALHGGHFAIASQPGEGTIITIEIAVDGSGAVCAEDAGQG
CHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCCEEECCCCCC
ATVEFPPRLKGAVNAGAELGEGRFDGRAQAKIA
CEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVLSNIGGWVTALVDRAATSWLSRTGGGEAVRQRELAILRRLVLFSSAALIAAPIGLSA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHH
VTSPAVALPAGVAMVCAAFLFSAVGSIALARQGSSAGIATQTAEDFFLDATPGLVFFLDP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHEEECCCCEEEEECC
HGSVATIGGRDRRDFLAWMRDPKGRGFLEQVHVSDRILFLQALDSLRRGEDAECVDLRID
CCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
RPSVARDQRQFAYLRMDMTARRDADGELAAVIAQLRDVSVEQQLRAEAQNRVADAESAND
CCCHHHHHHHHHHHEECHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCH
AKSRFLAAVSHELRTPLNAILGFSDILIGEYFGKFENDRQREYVSLVRESGAHLLSVVNT
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
MLDMSKIEAGRYELILEPFDIASSVKSCESMLALQAKTKGLTLTSRIQRGLGEIVADQRA
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IQQILINLVGNAIKFTEAGGVVSVDAAARDGILKLTVSDTGIGIAADKLALLGQPFVQIQ
HHHHHHHHHCCCEEEECCCCEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHC
NDYTRRFEGTGLGLSLVKGLVALHGGHFAIASQPGEGTIITIEIAVDGSGAVCAEDAGQG
CHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCCEEECCCCCC
ATVEFPPRLKGAVNAGAELGEGRFDGRAQAKIA
CEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]