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The map label for this gene is gntR [H]

Identifier: 209548368

GI number: 209548368

Start: 780587

End: 781624

Strand: Direct

Name: gntR [H]

Synonym: Rleg2_0764

Alternate gene names: 209548368

Gene position: 780587-781624 (Clockwise)

Preceding gene: 209548366

Following gene: 209548369

Centisome position: 17.2

GC content: 63.87

Gene sequence:

>1038_bases
ATGAAAAAGGCAGTGGAGCGGGGGCGCAACGGCAAGCGCGGCGCGCATGTGACGTTGAGCGATGTGGCGAAGAAGGTGGG
CGTCAGCCCGATCACCATCTCGCGTGCGCTTCGCAACCCTCAGATCGTTTCGGAGGATCTGCGCGAGGTGATCCTGCGTA
CGGTGGAGCAGATGGGTTATATCCCCAATCTCGCTGCTCGCGCCTTGGCCGGCCGCCACAACGGTATCGTCGGCGTTCTC
ACGCCGGCCTTGCACCAATACGGCTTCACCGGCCTGATGGTCGGCATCGAGGATCGCTTCCGCGACACCGAGCTCACCGT
GCAATATTCCAATACTCTCCGCCATGCCGAGGGGGAGGCCGGCCTGCTGAAATCCTTCCTGACCCAGAAGCCGGCCGGCG
TCATCATCGCCGGCGCCGAATCCTATCGCGATCTTCTGCCGCTGATCGAACGCGCCGCCTGTCCCATCGCCCATATCACC
GATCTCAGCCAGGAGCCGCAAACGCTGGTTGTCGGCCTCGATCATTATACGGCAGGCGCCGAACCCACCCGTTTCCTTCT
GTCGAGGGGCTATAACAGGATCGCTTTCTTCGGCCGCGGCGCCGATGTCCGCTCGCGCCGCCGCATCGAAGGTTATGAGG
CTGTGATGCGGGACGCCGGGCGTTTCGACCCCGATCTCATCATCGGCGGGGAGGCGGCAAGCCGCACGGGCCTCGGCAGG
GAGCTGTTTTCCCGCCTGTTGCAGCGCGTGCCCGATGTCGATGCCGTCTTTGCCCAGAGCGACGAACTGGCGCTCGGCGT
CCTCATCGAATGCAAGGAGCGCGGCATCCGCGTGCCTGAGGATCTCGGCATCTGCGGCTTCAACGATCTGGAGTTCTCGG
CCTTCATCGAGCCGTCGCTGACGACGGTGCACATACCGCGCTACGATATCGGCTACCGCGTCGCCGACATGCTGCTGCGC
GCCGTCCGCGACGAGCCGGCCGATGAAGACAAGGCCGACCTCGGCTTTACCATTATTCCGCGTGGTTCGACGCGATAA

Upstream 100 bases:

>100_bases
TGCGAATATAAAATGTTAGTAGACTCTAAATTATTTATTCTTCAGAAAGTGAAGACTGCGAATCGGGGCAGCTGAGTCTC
GCGGTGGCATATGAGGGGCG

Downstream 100 bases:

>100_bases
TCTGGTCAGACACCGCGACAATAGACGTGGAGCCGAGCCTTGCTGAAGCCTTCACTAGGCATGGTCGGGATTATTCCGTA
TATGGTCAGAATGGCAATCA

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKKAVERGRNGKRGAHVTLSDVAKKVGVSPITISRALRNPQIVSEDLREVILRTVEQMGYIPNLAARALAGRHNGIVGVL
TPALHQYGFTGLMVGIEDRFRDTELTVQYSNTLRHAEGEAGLLKSFLTQKPAGVIIAGAESYRDLLPLIERAACPIAHIT
DLSQEPQTLVVGLDHYTAGAEPTRFLLSRGYNRIAFFGRGADVRSRRRIEGYEAVMRDAGRFDPDLIIGGEAASRTGLGR
ELFSRLLQRVPDVDAVFAQSDELALGVLIECKERGIRVPEDLGICGFNDLEFSAFIEPSLTTVHIPRYDIGYRVADMLLR
AVRDEPADEDKADLGFTIIPRGSTR

Sequences:

>Translated_345_residues
MKKAVERGRNGKRGAHVTLSDVAKKVGVSPITISRALRNPQIVSEDLREVILRTVEQMGYIPNLAARALAGRHNGIVGVL
TPALHQYGFTGLMVGIEDRFRDTELTVQYSNTLRHAEGEAGLLKSFLTQKPAGVIIAGAESYRDLLPLIERAACPIAHIT
DLSQEPQTLVVGLDHYTAGAEPTRFLLSRGYNRIAFFGRGADVRSRRRIEGYEAVMRDAGRFDPDLIIGGEAASRTGLGR
ELFSRLLQRVPDVDAVFAQSDELALGVLIECKERGIRVPEDLGICGFNDLEFSAFIEPSLTTVHIPRYDIGYRVADMLLR
AVRDEPADEDKADLGFTIIPRGSTR
>Mature_345_residues
MKKAVERGRNGKRGAHVTLSDVAKKVGVSPITISRALRNPQIVSEDLREVILRTVEQMGYIPNLAARALAGRHNGIVGVL
TPALHQYGFTGLMVGIEDRFRDTELTVQYSNTLRHAEGEAGLLKSFLTQKPAGVIIAGAESYRDLLPLIERAACPIAHIT
DLSQEPQTLVVGLDHYTAGAEPTRFLLSRGYNRIAFFGRGADVRSRRRIEGYEAVMRDAGRFDPDLIIGGEAASRTGLGR
ELFSRLLQRVPDVDAVFAQSDELALGVLIECKERGIRVPEDLGICGFNDLEFSAFIEPSLTTVHIPRYDIGYRVADMLLR
AVRDEPADEDKADLGFTIIPRGSTR

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=329, Percent_Identity=34.3465045592705, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=30, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1790369, Length=340, Percent_Identity=27.9411764705882, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788474, Length=301, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790194, Length=339, Percent_Identity=25.6637168141593, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787948, Length=316, Percent_Identity=23.7341772151899, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789068, Length=294, Percent_Identity=27.2108843537415, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786540, Length=308, Percent_Identity=26.6233766233766, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=25.085910652921, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787906, Length=321, Percent_Identity=24.9221183800623, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787580, Length=323, Percent_Identity=22.9102167182663, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789456, Length=327, Percent_Identity=26.605504587156, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37948; Mature: 37948

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAVERGRNGKRGAHVTLSDVAKKVGVSPITISRALRNPQIVSEDLREVILRTVEQMGY
CCCHHHCCCCCCCCCEEEHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
IPNLAARALAGRHNGIVGVLTPALHQYGFTGLMVGIEDRFRDTELTVQYSNTLRHAEGEA
CCCHHHHHHHCCCCCEEEHHHHHHHHCCCCEEEEEHHHCCCCCEEEEEECCHHHHCCCHH
GLLKSFLTQKPAGVIIAGAESYRDLLPLIERAACPIAHITDLSQEPQTLVVGLDHYTAGA
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEECCCCCCC
EPTRFLLSRGYNRIAFFGRGADVRSRRRIEGYEAVMRDAGRFDPDLIIGGEAASRTGLGR
CHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHCCCCCCH
ELFSRLLQRVPDVDAVFAQSDELALGVLIECKERGIRVPEDLGICGFNDLEFSAFIEPSL
HHHHHHHHHCCCCHHHHCCCCCCEEHEEEEEHHCCCCCCHHCCCCCCCCCCEEEEECCCC
TTVHIPRYDIGYRVADMLLRAVRDEPADEDKADLGFTIIPRGSTR
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure
MKKAVERGRNGKRGAHVTLSDVAKKVGVSPITISRALRNPQIVSEDLREVILRTVEQMGY
CCCHHHCCCCCCCCCEEEHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
IPNLAARALAGRHNGIVGVLTPALHQYGFTGLMVGIEDRFRDTELTVQYSNTLRHAEGEA
CCCHHHHHHHCCCCCEEEHHHHHHHHCCCCEEEEEHHHCCCCCEEEEEECCHHHHCCCHH
GLLKSFLTQKPAGVIIAGAESYRDLLPLIERAACPIAHITDLSQEPQTLVVGLDHYTAGA
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEECCCCCCC
EPTRFLLSRGYNRIAFFGRGADVRSRRRIEGYEAVMRDAGRFDPDLIIGGEAASRTGLGR
CHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHCCCCCCH
ELFSRLLQRVPDVDAVFAQSDELALGVLIECKERGIRVPEDLGICGFNDLEFSAFIEPSL
HHHHHHHHHCCCCHHHHCCCCCCEEHEEEEEHHCCCCCCHHCCCCCCCCCCEEEEECCCC
TTVHIPRYDIGYRVADMLLRAVRDEPADEDKADLGFTIIPRGSTR
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]