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The map label for this gene is mntH [H]

Identifier: 209548132

GI number: 209548132

Start: 539844

End: 541184

Strand: Reverse

Name: mntH [H]

Synonym: Rleg2_0526

Alternate gene names: 209548132

Gene position: 541184-539844 (Counterclockwise)

Preceding gene: 209548144

Following gene: 209548129

Centisome position: 11.93

GC content: 63.83

Gene sequence:

>1341_bases
ATGGACGCCCTGAATCCGAATGCAAACCGCGGCTGGCGGCACGAACGCGGCGAGGCGTCGCTATCGGATGTCTACCGCAC
CGTCGGAACCGGGCGTCACAGCTCCAGATGGCGGCGGGCGGCGGCTTTCGCCGGACCCGGCTACATGGTCGCGGTCGGTT
ACATGGATCCCGGCAACTGGGCGACGTCGCTCGCCGGCGGTTCGAAATTCGGCTATGCGCTGTTGACCGTCGCGCTGCTT
TCCAACCTGATGGCGATCGTGCTGCAATCGCTCTGCGCGCGTCTGGCGATCGCCTCCGGCCGCGACCTGGCGCAGGCCTG
CCGCGACGCCTTCCCCAGATATGTCTCGGTGCCGCTCTGGGCCTTTGCCGAGATCGCCATCATCGCCACCGATATCGCCG
AGGTGATCGGCACGGCGATCGGCCTCAACCTCTTGATGGGCATCCCGCTCGAACTCGGCGTGCTGATCACCGCGCTCGAC
GTCTTCGTCATTCTCTTCCTGCAGAAGCTTGGTTTCCGCTGGGTGGAAGCCTTCATCATCGCCCTGCTCGGCGTCATCGC
GATCTGCTTCGGTGTGCAGATCCTGCTGGCCGACCCGCAATGGGGCGCCGTCGTCACCGGCTTCTTCCCGACGACGGAGA
TCGTCACCAATCCGGAGATGCTCTATCTGGCGCTCGGCATTCTCGGTGCAACCGTCATGCCGCACAATCTCTACCTTCAC
TCCGGCATCGTTCAGACGCGGGCCTATGGCCACACCGTTCCCGAAAAGAAGGAGGCGCTGACCTTTGCGACGATCGACTC
GACGGTGGCTCTGTGCTTCGCGCTGCTGATCAACGCCTCGATCCTGATCCTGGCCGCTGCCGCCTTCAATGCAAACGGCA
AAACCGATGTCGTCGAACTCGGCGACGCCTATTCGCTGCTGTCGCCGCTGCTGGGGCTCGCCATCGCGCCGACGCTGTTC
GGCATTGCGCTGCTCTGCTGCGGCCTCAACTCGACGGTGACGGCAACGCTTGCCGGCCAGATCGTCATGGAAGGCTTCCT
GAAGATCCGGCTGAAGCCGTGGATACGGCGGCTGATCACCCGCGCCATCGCCATCGTGCCGGCGGCAATCGTCACCATCT
GGTATGGCGACAAAGGCACGGCCGAGCTGTTGATCCTCACCCAGGTGGTGCTCAGCCTGCAGCTTTCCTTCGCCGTCTTC
CCGCTCGTGATGTTCACCGCCAACAAGGCCAAGATGGGCGAGCTCGTGGCGCCGCGCTGGCTGAGCGGCATTGCCTATCT
GATCGCGATCGTGATTGCCGGCCTGAACGTCAAGCTGCTCTTCGACTTCGTCACCGGCTAA

Upstream 100 bases:

>100_bases
TGGGGCCTGAAAACACCGGATTGATTTTCTTGTTGCGAATGACTTGCATTATCATTCTAATTCGTCATAGTGCCACTCAC
GACTAATAGGTGGAAATCGC

Downstream 100 bases:

>100_bases
AGCAATCGCGCGGAAACTGAACCGGCCTAAAGCCGGGCATAGGCCGCCCGGCCATTGTTGAAATCATCGACGAGAGGGGA
GAACTTGTGGCTCCCCTCTT

Product: manganese transporter MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MDALNPNANRGWRHERGEASLSDVYRTVGTGRHSSRWRRAAAFAGPGYMVAVGYMDPGNWATSLAGGSKFGYALLTVALL
SNLMAIVLQSLCARLAIASGRDLAQACRDAFPRYVSVPLWAFAEIAIIATDIAEVIGTAIGLNLLMGIPLELGVLITALD
VFVILFLQKLGFRWVEAFIIALLGVIAICFGVQILLADPQWGAVVTGFFPTTEIVTNPEMLYLALGILGATVMPHNLYLH
SGIVQTRAYGHTVPEKKEALTFATIDSTVALCFALLINASILILAAAAFNANGKTDVVELGDAYSLLSPLLGLAIAPTLF
GIALLCCGLNSTVTATLAGQIVMEGFLKIRLKPWIRRLITRAIAIVPAAIVTIWYGDKGTAELLILTQVVLSLQLSFAVF
PLVMFTANKAKMGELVAPRWLSGIAYLIAIVIAGLNVKLLFDFVTG

Sequences:

>Translated_446_residues
MDALNPNANRGWRHERGEASLSDVYRTVGTGRHSSRWRRAAAFAGPGYMVAVGYMDPGNWATSLAGGSKFGYALLTVALL
SNLMAIVLQSLCARLAIASGRDLAQACRDAFPRYVSVPLWAFAEIAIIATDIAEVIGTAIGLNLLMGIPLELGVLITALD
VFVILFLQKLGFRWVEAFIIALLGVIAICFGVQILLADPQWGAVVTGFFPTTEIVTNPEMLYLALGILGATVMPHNLYLH
SGIVQTRAYGHTVPEKKEALTFATIDSTVALCFALLINASILILAAAAFNANGKTDVVELGDAYSLLSPLLGLAIAPTLF
GIALLCCGLNSTVTATLAGQIVMEGFLKIRLKPWIRRLITRAIAIVPAAIVTIWYGDKGTAELLILTQVVLSLQLSFAVF
PLVMFTANKAKMGELVAPRWLSGIAYLIAIVIAGLNVKLLFDFVTG
>Mature_446_residues
MDALNPNANRGWRHERGEASLSDVYRTVGTGRHSSRWRRAAAFAGPGYMVAVGYMDPGNWATSLAGGSKFGYALLTVALL
SNLMAIVLQSLCARLAIASGRDLAQACRDAFPRYVSVPLWAFAEIAIIATDIAEVIGTAIGLNLLMGIPLELGVLITALD
VFVILFLQKLGFRWVEAFIIALLGVIAICFGVQILLADPQWGAVVTGFFPTTEIVTNPEMLYLALGILGATVMPHNLYLH
SGIVQTRAYGHTVPEKKEALTFATIDSTVALCFALLINASILILAAAAFNANGKTDVVELGDAYSLLSPLLGLAIAPTLF
GIALLCCGLNSTVTATLAGQIVMEGFLKIRLKPWIRRLITRAIAIVPAAIVTIWYGDKGTAELLILTQVVLSLQLSFAVF
PLVMFTANKAKMGELVAPRWLSGIAYLIAIVIAGLNVKLLFDFVTG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=426, Percent_Identity=36.150234741784, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI295293175, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI295293173, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI10835169, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI295293167, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI295293178, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI295293171, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI295293169, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1788736, Length=420, Percent_Identity=38.3333333333333, Blast_Score=265, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17569473, Length=402, Percent_Identity=35.3233830845771, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI193210616, Length=472, Percent_Identity=31.5677966101695, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71999499, Length=439, Percent_Identity=32.5740318906606, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71993856, Length=253, Percent_Identity=33.9920948616601, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323062, Length=399, Percent_Identity=42.1052631578947, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6324450, Length=446, Percent_Identity=36.7713004484305, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6321841, Length=450, Percent_Identity=39.1111111111111, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24648607, Length=433, Percent_Identity=35.1039260969977, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI281362176, Length=433, Percent_Identity=35.1039260969977, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24648609, Length=433, Percent_Identity=35.1039260969977, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI45553443, Length=412, Percent_Identity=35.6796116504854, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 47677; Mature: 47677

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALNPNANRGWRHERGEASLSDVYRTVGTGRHSSRWRRAAAFAGPGYMVAVGYMDPGNW
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCH
ATSLAGGSKFGYALLTVALLSNLMAIVLQSLCARLAIASGRDLAQACRDAFPRYVSVPLW
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHCCCHHH
AFAEIAIIATDIAEVIGTAIGLNLLMGIPLELGVLITALDVFVILFLQKLGFRWVEAFII
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLGVIAICFGVQILLADPQWGAVVTGFFPTTEIVTNPEMLYLALGILGATVMPHNLYLH
HHHHHHHHHHCCEEEEECCCCCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEC
SGIVQTRAYGHTVPEKKEALTFATIDSTVALCFALLINASILILAAAAFNANGKTDVVEL
CCHHHHHHCCCCCCCHHHHEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEC
GDAYSLLSPLLGLAIAPTLFGIALLCCGLNSTVTATLAGQIVMEGFLKIRLKPWIRRLIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAIAIVPAAIVTIWYGDKGTAELLILTQVVLSLQLSFAVFPLVMFTANKAKMGELVAPRW
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH
LSGIAYLIAIVIAGLNVKLLFDFVTG
HHHHHHHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MDALNPNANRGWRHERGEASLSDVYRTVGTGRHSSRWRRAAAFAGPGYMVAVGYMDPGNW
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCH
ATSLAGGSKFGYALLTVALLSNLMAIVLQSLCARLAIASGRDLAQACRDAFPRYVSVPLW
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHCCCHHH
AFAEIAIIATDIAEVIGTAIGLNLLMGIPLELGVLITALDVFVILFLQKLGFRWVEAFII
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLGVIAICFGVQILLADPQWGAVVTGFFPTTEIVTNPEMLYLALGILGATVMPHNLYLH
HHHHHHHHHHCCEEEEECCCCCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEC
SGIVQTRAYGHTVPEKKEALTFATIDSTVALCFALLINASILILAAAAFNANGKTDVVEL
CCHHHHHHCCCCCCCHHHHEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEC
GDAYSLLSPLLGLAIAPTLFGIALLCCGLNSTVTATLAGQIVMEGFLKIRLKPWIRRLIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAIAIVPAAIVTIWYGDKGTAELLILTQVVLSLQLSFAVFPLVMFTANKAKMGELVAPRW
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH
LSGIAYLIAIVIAGLNVKLLFDFVTG
HHHHHHHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]