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The map label for this gene is hisZ [H]

Identifier: 209548072

GI number: 209548072

Start: 475682

End: 476803

Strand: Direct

Name: hisZ [H]

Synonym: Rleg2_0465

Alternate gene names: 209548072

Gene position: 475682-476803 (Clockwise)

Preceding gene: 209548071

Following gene: 209548073

Centisome position: 10.48

GC content: 65.69

Gene sequence:

>1122_bases
ATGCCCCTGATCAACCTCCCCGAATTTGCCAGTGACCTGCTGGCCGAGTTCGACGCCCGCAAGGTCGAGCGCATCGATAC
GCCGGTCATTCAGCCGGCCGAGCCTTTCCTCGATATCGCCGGCGAGGATCTGCGCCGCCGCATCTTCATGACGGAGAGTG
AGACCGGCGCCAGCCTCTGCCTGCGTCCCGAATTCACCATCCCCGTCTGTCTGCGCCACATCGAGACGGCGACCGGCACG
CCGAAGCGTTACGCCTATCTTGGCGAGGTGTTCCGCCAGCGCCGCGACGGCGCCAATGAATTCTACCAGGCCGGCATCGA
GGATCTCGGTGATATCAACATACCGAGCGCCGACGCCCGCGCCATCGGCGATGCCACCGGCATTCTCGCCCGCCTGCTGC
CAGGCCGGCGCCTGTCGGTGACGCTGGGCGACCAGGCGGTGTTCGAGGCGGTCGTCCAGGCGCTCGGCCTGCCGCTCGGC
TGGCAGAAGCGGCTGATCCACGCCTTCGGCAACATGACGCAGCTCGAAGCGCTGCTGGCCGGTCTCGTCAGTCCGCAATT
CGTCACCGGGCTCGATGACGATGTCGCCAAGCTTGTCGCATCAGGCGACGAGCAGGCGCTGGTCTCCCATCTCGAGCAGG
AAATGCAGGCGACGGGTTATTCGGCCAATGCCGGCCGCTCGCCGCTGGAGATTGCCCGGCGGCTCAAGGAAAAGCTCATC
CTCTCCGAAACGCGCCTCGACGATGCGGCCTTCCATGTGCTGGAAGAGTTCCTGTCGCTCGACGTGCCGCTCGTCAATGC
GTCCGCAGCACTGGCTGGCTTTGCCGATGCTGCCGGGCTGAAACTCGGCAATGCGCTTTCCCGCTTCAACGGCCGGGTCG
CCGCCCTTGCCGATGCCGGCGTCGATCTTTCCTGCCTCGATTACCGCGCCGCCTTCGGACGGCCGCTCGACTATTACACC
GGCCTCGTCTTCGAGGTGACGGTGGAGGGGTCGGCGGCGGTTCTGGCCGGCGGCGGCCGTTTCGATAAACTCCTGACCTT
CCTCGGTGCGACGGACCGCATTCCGGCTGTCGGCTTCTCCTTCTGGCTCGACCGCATCGAAACCGAAAGGGCAGCCGTAT
GA

Upstream 100 bases:

>100_bases
CCGCGCCTCTTGCCGATCTCCCCCCTTGTGGGGGAGATGCCCGGCGGGGCAGAGGGGGGTGCCTTCCGGCACGCCCTTCG
CCTACCGTTTGGAGTGCGGC

Downstream 100 bases:

>100_bases
CCATCACCATCGCGCTTCCCTCCAAGGGCCGGATGAAGGACGAAGCTTCGGCGATCTTCGAACGGGCCGGCATGCCGATC
ACCGCTGTCGGCAATGACCG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MPLINLPEFASDLLAEFDARKVERIDTPVIQPAEPFLDIAGEDLRRRIFMTESETGASLCLRPEFTIPVCLRHIETATGT
PKRYAYLGEVFRQRRDGANEFYQAGIEDLGDINIPSADARAIGDATGILARLLPGRRLSVTLGDQAVFEAVVQALGLPLG
WQKRLIHAFGNMTQLEALLAGLVSPQFVTGLDDDVAKLVASGDEQALVSHLEQEMQATGYSANAGRSPLEIARRLKEKLI
LSETRLDDAAFHVLEEFLSLDVPLVNASAALAGFADAAGLKLGNALSRFNGRVAALADAGVDLSCLDYRAAFGRPLDYYT
GLVFEVTVEGSAAVLAGGGRFDKLLTFLGATDRIPAVGFSFWLDRIETERAAV

Sequences:

>Translated_373_residues
MPLINLPEFASDLLAEFDARKVERIDTPVIQPAEPFLDIAGEDLRRRIFMTESETGASLCLRPEFTIPVCLRHIETATGT
PKRYAYLGEVFRQRRDGANEFYQAGIEDLGDINIPSADARAIGDATGILARLLPGRRLSVTLGDQAVFEAVVQALGLPLG
WQKRLIHAFGNMTQLEALLAGLVSPQFVTGLDDDVAKLVASGDEQALVSHLEQEMQATGYSANAGRSPLEIARRLKEKLI
LSETRLDDAAFHVLEEFLSLDVPLVNASAALAGFADAAGLKLGNALSRFNGRVAALADAGVDLSCLDYRAAFGRPLDYYT
GLVFEVTVEGSAAVLAGGGRFDKLLTFLGATDRIPAVGFSFWLDRIETERAAV
>Mature_372_residues
PLINLPEFASDLLAEFDARKVERIDTPVIQPAEPFLDIAGEDLRRRIFMTESETGASLCLRPEFTIPVCLRHIETATGTP
KRYAYLGEVFRQRRDGANEFYQAGIEDLGDINIPSADARAIGDATGILARLLPGRRLSVTLGDQAVFEAVVQALGLPLGW
QKRLIHAFGNMTQLEALLAGLVSPQFVTGLDDDVAKLVASGDEQALVSHLEQEMQATGYSANAGRSPLEIARRLKEKLIL
SETRLDDAAFHVLEEFLSLDVPLVNASAALAGFADAAGLKLGNALSRFNGRVAALADAGVDLSCLDYRAAFGRPLDYYTG
LVFEVTVEGSAAVLAGGGRFDKLLTFLGATDRIPAVGFSFWLDRIETERAAV

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 40308; Mature: 40177

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLINLPEFASDLLAEFDARKVERIDTPVIQPAEPFLDIAGEDLRRRIFMTESETGASLC
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHEEECCCCCCCEEE
LRPEFTIPVCLRHIETATGTPKRYAYLGEVFRQRRDGANEFYQAGIEDLGDINIPSADAR
ECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHH
AIGDATGILARLLPGRRLSVTLGDQAVFEAVVQALGLPLGWQKRLIHAFGNMTQLEALLA
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
GLVSPQFVTGLDDDVAKLVASGDEQALVSHLEQEMQATGYSANAGRSPLEIARRLKEKLI
HHCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LSETRLDDAAFHVLEEFLSLDVPLVNASAALAGFADAAGLKLGNALSRFNGRVAALADAG
HHHHCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
VDLSCLDYRAAFGRPLDYYTGLVFEVTVEGSAAVLAGGGRFDKLLTFLGATDRIPAVGFS
CCHHHHHHHHHHCCCHHHHCCEEEEEEECCCEEEEECCCHHHHHHHHHCCCCCCCHHHHH
FWLDRIETERAAV
HHHHHHHHHHCCC
>Mature Secondary Structure 
PLINLPEFASDLLAEFDARKVERIDTPVIQPAEPFLDIAGEDLRRRIFMTESETGASLC
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHEEECCCCCCCEEE
LRPEFTIPVCLRHIETATGTPKRYAYLGEVFRQRRDGANEFYQAGIEDLGDINIPSADAR
ECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHH
AIGDATGILARLLPGRRLSVTLGDQAVFEAVVQALGLPLGWQKRLIHAFGNMTQLEALLA
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
GLVSPQFVTGLDDDVAKLVASGDEQALVSHLEQEMQATGYSANAGRSPLEIARRLKEKLI
HHCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LSETRLDDAAFHVLEEFLSLDVPLVNASAALAGFADAAGLKLGNALSRFNGRVAALADAG
HHHHCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
VDLSCLDYRAAFGRPLDYYTGLVFEVTVEGSAAVLAGGGRFDKLLTFLGATDRIPAVGFS
CCHHHHHHHHHHCCCHHHHCCEEEEEEECCCEEEEECCCHHHHHHHHHCCCCCCCHHHHH
FWLDRIETERAAV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA