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The map label for this gene is gppA [H]

Identifier: 209548034

GI number: 209548034

Start: 437594

End: 439156

Strand: Direct

Name: gppA [H]

Synonym: Rleg2_0427

Alternate gene names: 209548034

Gene position: 437594-439156 (Clockwise)

Preceding gene: 209548033

Following gene: 209548035

Centisome position: 9.64

GC content: 67.56

Gene sequence:

>1563_bases
GTGGAAGACCCCGAAGGCGGCGCGAAGCCGCAATTTGACGGGGCGTCGGCGGCAGGGCGCAAGGACGGCAAGAAGTCCAG
GCGCCGCAAGGGCAAGCGTGGCGGGCAATCCCGCAACGCGGCTCATCCCGCTTCGCATGAGCTTTCCGGCAATGCCGGGC
AGTCTGCGCGCCCGATGGAAGATGCGGCCGGAAATCCGGCCCGCAAGCGAAAGCGTCGCCGCCGTGGCGGCCAAGGCGTT
GCGCAGGACGGTTCATCTCATCCTCAAGCGATGGAACAGGCGAGAGCGGCGGGCAATGCCGCCCGGGCCGAAGGCGAGCA
GACGCCCGGCCGGCGCAATCGCCGCAAACATCGGGGCAAGCGCGGCCTTCAGGGCCGGCCGCTGACGGCGGCAAAACCTT
CCCCGCCACAGCAGGAAAGCCGCGCCGAAGAGACGGTGCAGCGCGCCGAGCCGCGCGAGGCGCAGAACGGCGCAAATGCC
GGCCGCAGGGGGCGCCAGGATGGCCATATCAATTCCGGTTATCCAGGGGATCGCCAGGCCGGCGAACATGCGTGGCCGGA
CGAACTCTATGCCGCTCTCGATCTCGGCACCAACAATTGCCGTCTTCTCATCGCTCAGCCGACCCGCCCGGGGCAATTCC
GGGTGGTCGACGCCTTTTCACGCATCGTGCGCCTTGGCGAAGGCCTGGCGGCCAGCGGCCGGCTATCCGACGAGGCGATG
GAAAGGGCGATCGAAGCGCTGAGGATCTGCGCCTCCAAGCTCAGAAACCGAGAGATCCGCCGCATGCGGCTGATCGCCAC
CGAAGCCTGCCGCCAGGCGGTCAATGGTGAAGAGTTCCTCGCCCGCGTCGTTGCCGAAACCGGCCTTGCGCTCGAGATCA
TCGATCGTGAGACCGAAGCGCGGCTTGCCGTCTCCGGCTGCTCCTCGCTGGTCGGGCGTGAGACCCGTTCCGTCGTGCTC
TTCGATATCGGCGGCGGCTCGTCGGAGATCGCCGTCATCCGCATCGGCGACAATCGGTTCAGTCGCCTCGCCAATCACAT
CACCCACTGGACCTCACTGCCGGTCGGCGTCGTCACGCTGTCGGAGCGTCATGGCGGCCGCGACGTCACTCCGGAAGCTT
TCGAAGGCATGGTGCGGGAAGTTGGCGGCATGCTCGAAGGCTTCGATTGCCCGGAGATCGAGGTCGCCCAGACCGGCGAC
TTCCATCTGATCGGCACATCGGGCACGGTGACGACGCTTGCCGGCGTCCATCTCGACCTGCCGCGTTATGACCGGCGCAA
GGTCGACGGCATCTGGCTGTCCGACGACGAGGTCTCCGCCATGCAGGCAAAACTGCTCTCCTGGAATTTCGAAAGCCGTG
CCGCCAATCCCTGCATCGGGCCGGATCGGGCCGATCTGGTGCTCGCCGGCTGCGCCATCCTCGAGGCGATCCGCCGCCGC
TGGCCGAGCCCGCGCATGCGGGTCGCCGATCGCGGCTTGAGGGAAGGCCTGCTCACCGACATGATGGCCGATGACGGCGT
GTGGCGGCGCAACCGCAACCGCCGCGGCCAGCGAGCCAGATAA

Upstream 100 bases:

>100_bases
GGTGATTTTGGCGGGCGCTGATATTCTTGCCGCAACGCAAAAATCGAACGAGCGCCTGCTGCATACCTCAGGGAGTTGCG
CGGCGCGGTGGAAAAACAAC

Downstream 100 bases:

>100_bases
GGAAAAGGCATGACCAAGGCACCGATCGCGGGAAACCGCACCGGCCGCAAGCTCGGCCAGCGCGTCAAGAACAAGAAGAT
GAAGGCCTCCTCTCGCCAAT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MEDPEGGAKPQFDGASAAGRKDGKKSRRRKGKRGGQSRNAAHPASHELSGNAGQSARPMEDAAGNPARKRKRRRRGGQGV
AQDGSSHPQAMEQARAAGNAARAEGEQTPGRRNRRKHRGKRGLQGRPLTAAKPSPPQQESRAEETVQRAEPREAQNGANA
GRRGRQDGHINSGYPGDRQAGEHAWPDELYAALDLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLAASGRLSDEAM
ERAIEALRICASKLRNREIRRMRLIATEACRQAVNGEEFLARVVAETGLALEIIDRETEARLAVSGCSSLVGRETRSVVL
FDIGGGSSEIAVIRIGDNRFSRLANHITHWTSLPVGVVTLSERHGGRDVTPEAFEGMVREVGGMLEGFDCPEIEVAQTGD
FHLIGTSGTVTTLAGVHLDLPRYDRRKVDGIWLSDDEVSAMQAKLLSWNFESRAANPCIGPDRADLVLAGCAILEAIRRR
WPSPRMRVADRGLREGLLTDMMADDGVWRRNRNRRGQRAR

Sequences:

>Translated_520_residues
MEDPEGGAKPQFDGASAAGRKDGKKSRRRKGKRGGQSRNAAHPASHELSGNAGQSARPMEDAAGNPARKRKRRRRGGQGV
AQDGSSHPQAMEQARAAGNAARAEGEQTPGRRNRRKHRGKRGLQGRPLTAAKPSPPQQESRAEETVQRAEPREAQNGANA
GRRGRQDGHINSGYPGDRQAGEHAWPDELYAALDLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLAASGRLSDEAM
ERAIEALRICASKLRNREIRRMRLIATEACRQAVNGEEFLARVVAETGLALEIIDRETEARLAVSGCSSLVGRETRSVVL
FDIGGGSSEIAVIRIGDNRFSRLANHITHWTSLPVGVVTLSERHGGRDVTPEAFEGMVREVGGMLEGFDCPEIEVAQTGD
FHLIGTSGTVTTLAGVHLDLPRYDRRKVDGIWLSDDEVSAMQAKLLSWNFESRAANPCIGPDRADLVLAGCAILEAIRRR
WPSPRMRVADRGLREGLLTDMMADDGVWRRNRNRRGQRAR
>Mature_520_residues
MEDPEGGAKPQFDGASAAGRKDGKKSRRRKGKRGGQSRNAAHPASHELSGNAGQSARPMEDAAGNPARKRKRRRRGGQGV
AQDGSSHPQAMEQARAAGNAARAEGEQTPGRRNRRKHRGKRGLQGRPLTAAKPSPPQQESRAEETVQRAEPREAQNGANA
GRRGRQDGHINSGYPGDRQAGEHAWPDELYAALDLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLAASGRLSDEAM
ERAIEALRICASKLRNREIRRMRLIATEACRQAVNGEEFLARVVAETGLALEIIDRETEARLAVSGCSSLVGRETRSVVL
FDIGGGSSEIAVIRIGDNRFSRLANHITHWTSLPVGVVTLSERHGGRDVTPEAFEGMVREVGGMLEGFDCPEIEVAQTGD
FHLIGTSGTVTTLAGVHLDLPRYDRRKVDGIWLSDDEVSAMQAKLLSWNFESRAANPCIGPDRADLVLAGCAILEAIRRR
WPSPRMRVADRGLREGLLTDMMADDGVWRRNRNRRGQRAR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=319, Percent_Identity=28.2131661442006, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788848, Length=327, Percent_Identity=25.9938837920489, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 56805; Mature: 56805

Theoretical pI: Translated: 10.89; Mature: 10.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDPEGGAKPQFDGASAAGRKDGKKSRRRKGKRGGQSRNAAHPASHELSGNAGQSARPME
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
DAAGNPARKRKRRRRGGQGVAQDGSSHPQAMEQARAAGNAARAEGEQTPGRRNRRKHRGK
HHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHH
RGLQGRPLTAAKPSPPQQESRAEETVQRAEPREAQNGANAGRRGRQDGHINSGYPGDRQA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GEHAWPDELYAALDLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLAASGRLSDEAM
CCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCHHHH
ERAIEALRICASKLRNREIRRMRLIATEACRQAVNGEEFLARVVAETGLALEIIDRETEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCHHH
RLAVSGCSSLVGRETRSVVLFDIGGGSSEIAVIRIGDNRFSRLANHITHWTSLPVGVVTL
HHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEE
SERHGGRDVTPEAFEGMVREVGGMLEGFDCPEIEVAQTGDFHLIGTSGTVTTLAGVHLDL
ECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCHHHCCEEECC
PRYDRRKVDGIWLSDDEVSAMQAKLLSWNFESRAANPCIGPDRADLVLAGCAILEAIRRR
CCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WPSPRMRVADRGLREGLLTDMMADDGVWRRNRNRRGQRAR
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MEDPEGGAKPQFDGASAAGRKDGKKSRRRKGKRGGQSRNAAHPASHELSGNAGQSARPME
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
DAAGNPARKRKRRRRGGQGVAQDGSSHPQAMEQARAAGNAARAEGEQTPGRRNRRKHRGK
HHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHH
RGLQGRPLTAAKPSPPQQESRAEETVQRAEPREAQNGANAGRRGRQDGHINSGYPGDRQA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GEHAWPDELYAALDLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLAASGRLSDEAM
CCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCHHHH
ERAIEALRICASKLRNREIRRMRLIATEACRQAVNGEEFLARVVAETGLALEIIDRETEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCHHH
RLAVSGCSSLVGRETRSVVLFDIGGGSSEIAVIRIGDNRFSRLANHITHWTSLPVGVVTL
HHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEE
SERHGGRDVTPEAFEGMVREVGGMLEGFDCPEIEVAQTGDFHLIGTSGTVTTLAGVHLDL
ECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCHHHCCEEECC
PRYDRRKVDGIWLSDDEVSAMQAKLLSWNFESRAANPCIGPDRADLVLAGCAILEAIRRR
CCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WPSPRMRVADRGLREGLLTDMMADDGVWRRNRNRRGQRAR
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA