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The map label for this gene is galE [C]

Identifier: 209548018

GI number: 209548018

Start: 421892

End: 422737

Strand: Direct

Name: galE [C]

Synonym: Rleg2_0410

Alternate gene names: 209548018

Gene position: 421892-422737 (Clockwise)

Preceding gene: 209548017

Following gene: 209548019

Centisome position: 9.3

GC content: 57.21

Gene sequence:

>846_bases
ATGGTTGATGCCATCGTCACCGGTGCTGGCGGCTTTCTCGGGAAGCGTCTGATTGAGCGGCTTAAACAGGCCGGCGTTGA
CGTGCTTGCGGTTGACCGAACGCATGGTGATATAAGCGAAGAGGCAATCTGGCAGGCGCTTCCCGCAGCCGGCACGCTGT
TTCATCTTGCCGGCCGGACGTTTGTCCCGGATAGCTGGTCACAAGGCCCGAGTTTCATGGCCGCCAATGTTCTCGGTACA
CAGCATGCATTGAACTGGTGCAAGCGACACAAGGCGAGGCTCGTATTCGCAAGCGCCTATGTTTACGGAGTGCCGGAGCG
GCTGCCGATCCATGAAAGCGATCCGGTCAGGCCGAACAACCCCTACGCTCTTTCCAAACACCTTGCCGAACAACTTTGTG
AGTTTGCTGCCACACACGAGCAAATACCGGTGGTGGTGTTGCGTCTTTTCAATATATATGGGGCTGGGCAGCGACCGGAG
TTCCTGATACCGACGCTTCTGAACCGGATACGGGCGAAGCAGGACATTGAGGTCATGGACCTCAGTCCGCGGCGGGACTA
TGTCTTCGTTGACGATGTCCTGAGCGCCTTTGCCAAGGCCATGGATGTGTCGGAAGGTTACCACTGCATCAATATCGGCT
CCGGAATGTCATATTCGGTGCAGGAAATCATCGATATCTTGCAGCAAGCGGCCGGCACTGATCTACCAGTAGTGTCGTCT
TGCGCTGTTCGGCGGAATGAAATACCTGACGTGCGGGCCGATATTACGCGGGCTCGCGCCGTTCTCGGATGGCGGCCGGA
ATGGGATCTGCCCGCCGGCATCCGCGTGATGATGAAGGAGTCGTAA

Upstream 100 bases:

>100_bases
ACAGTGCGAGATTTTCCAGGCTATTGGCTCGATATTGGACGGCCCGACGATTATGCACTGGCGATCGAGCAGTTCGAAAC
CATGCAATCCAGGTTCTTGA

Downstream 100 bases:

>100_bases
ATTGAACGAGCGTTACGTTCCGATCAACAAGGGCAACTACTCGATGGACACGGACGAGCGCGAAGCCGCGTTCGACAAGT
TCCGAGGCGAAGGTTGGGAA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MVDAIVTGAGGFLGKRLIERLKQAGVDVLAVDRTHGDISEEAIWQALPAAGTLFHLAGRTFVPDSWSQGPSFMAANVLGT
QHALNWCKRHKARLVFASAYVYGVPERLPIHESDPVRPNNPYALSKHLAEQLCEFAATHEQIPVVVLRLFNIYGAGQRPE
FLIPTLLNRIRAKQDIEVMDLSPRRDYVFVDDVLSAFAKAMDVSEGYHCINIGSGMSYSVQEIIDILQQAAGTDLPVVSS
CAVRRNEIPDVRADITRARAVLGWRPEWDLPAGIRVMMKES

Sequences:

>Translated_281_residues
MVDAIVTGAGGFLGKRLIERLKQAGVDVLAVDRTHGDISEEAIWQALPAAGTLFHLAGRTFVPDSWSQGPSFMAANVLGT
QHALNWCKRHKARLVFASAYVYGVPERLPIHESDPVRPNNPYALSKHLAEQLCEFAATHEQIPVVVLRLFNIYGAGQRPE
FLIPTLLNRIRAKQDIEVMDLSPRRDYVFVDDVLSAFAKAMDVSEGYHCINIGSGMSYSVQEIIDILQQAAGTDLPVVSS
CAVRRNEIPDVRADITRARAVLGWRPEWDLPAGIRVMMKES
>Mature_281_residues
MVDAIVTGAGGFLGKRLIERLKQAGVDVLAVDRTHGDISEEAIWQALPAAGTLFHLAGRTFVPDSWSQGPSFMAANVLGT
QHALNWCKRHKARLVFASAYVYGVPERLPIHESDPVRPNNPYALSKHLAEQLCEFAATHEQIPVVVLRLFNIYGAGQRPE
FLIPTLLNRIRAKQDIEVMDLSPRRDYVFVDDVLSAFAKAMDVSEGYHCINIGSGMSYSVQEIIDILQQAAGTDLPVVSS
CAVRRNEIPDVRADITRARAVLGWRPEWDLPAGIRVMMKES

Specific function: Galactose metabolism; third step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=316, Percent_Identity=25.3164556962025, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI56118217, Length=316, Percent_Identity=25.3164556962025, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI189083684, Length=316, Percent_Identity=25.3164556962025, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI42516563, Length=297, Percent_Identity=23.5690235690236, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7657641, Length=233, Percent_Identity=27.4678111587983, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786974, Length=312, Percent_Identity=27.2435897435897, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=325, Percent_Identity=26.7692307692308, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71982038, Length=327, Percent_Identity=26.605504587156, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17539532, Length=297, Percent_Identity=23.5690235690236, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356223, Length=302, Percent_Identity=25.4966887417219, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19923002, Length=321, Percent_Identity=23.98753894081, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 31100; Mature: 31100

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDAIVTGAGGFLGKRLIERLKQAGVDVLAVDRTHGDISEEAIWQALPAAGTLFHLAGRT
CCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCC
FVPDSWSQGPSFMAANVLGTQHALNWCKRHKARLVFASAYVYGVPERLPIHESDPVRPNN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCCCCCCCCCCCCCC
PYALSKHLAEQLCEFAATHEQIPVVVLRLFNIYGAGQRPEFLIPTLLNRIRAKQDIEVMD
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEE
LSPRRDYVFVDDVLSAFAKAMDVSEGYHCINIGSGMSYSVQEIIDILQQAAGTDLPVVSS
CCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHH
CAVRRNEIPDVRADITRARAVLGWRPEWDLPAGIRVMMKES
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MVDAIVTGAGGFLGKRLIERLKQAGVDVLAVDRTHGDISEEAIWQALPAAGTLFHLAGRT
CCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCC
FVPDSWSQGPSFMAANVLGTQHALNWCKRHKARLVFASAYVYGVPERLPIHESDPVRPNN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCCCCCCCCCCCCCC
PYALSKHLAEQLCEFAATHEQIPVVVLRLFNIYGAGQRPEFLIPTLLNRIRAKQDIEVMD
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEE
LSPRRDYVFVDDVLSAFAKAMDVSEGYHCINIGSGMSYSVQEIIDILQQAAGTDLPVVSS
CCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHH
CAVRRNEIPDVRADITRARAVLGWRPEWDLPAGIRVMMKES
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]