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The map label for this gene is rmlA1 [C]

Identifier: 209548017

GI number: 209548017

Start: 421186

End: 421899

Strand: Direct

Name: rmlA1 [C]

Synonym: Rleg2_0409

Alternate gene names: 209548017

Gene position: 421186-421899 (Clockwise)

Preceding gene: 209548016

Following gene: 209548018

Centisome position: 9.28

GC content: 54.62

Gene sequence:

>714_bases
ATGTCTAGGCGAGCAGTCATTCTGGCAGGGGGAATGGGAACGCGGCTGCGCCCTTATACCGTCGTGCTTCCCAAGCCGCT
GATGCCGATCGGCGATTATCCTATTCTCGAAGTCATCATTCGCCAGCTGATATCAGGCGGGTTTCAGCATATAACGCTTG
CCGTCAATCATCAGGCTGAACTGATCAAAGCCTTTTTCCAGGATGGCGACAAATGGGGCGTGCGCATCGATTATTCGCTG
GAGGATCAGCCGCTCGGCACTATGGGTCCGCTACGGTTGATCAAGGATCTGCCTGAGAATTTTCTGGTGATGAACGGAGA
CATCCTGACGGACCTGAACTATGCCGATTTTCATGACACTCACGTCCGGGAGGGGAATATATTCACCATCTCGTCAAAGA
CACGGGAGCATCGCATAGACTACGGCGTTCTGGACACCAACGAGGCAGGGCTGCTGACGGGGTTCCGGGAGAAGCCGACG
GCCGAGTATAAAGTCAGCATGGGGGTCTACATGGTGTCTTCGGGGGCGGTCGAGCACATACCGCAACGTGGCGCCTACGG
TTTTGACCAGCTGATGCTTGATCTTCTTGCAGCCGGAAAGCCGGCAACAGTGCGAGATTTTCCAGGCTATTGGCTCGATA
TTGGACGGCCCGACGATTATGCACTGGCGATCGAGCAGTTCGAAACCATGCAATCCAGGTTCTTGAATGGTTGA

Upstream 100 bases:

>100_bases
GGATTCTCGCCTCGCTACAGCTTGAAAGACGGGCTCCAGGCGACGATTGAATGGCTGCGTCAGCCCGAGAATCTGGCGCG
GTATAAGGCGGATATTTTCA

Downstream 100 bases:

>100_bases
TGCCATCGTCACCGGTGCTGGCGGCTTTCTCGGGAAGCGTCTGATTGAGCGGCTTAAACAGGCCGGCGTTGACGTGCTTG
CGGTTGACCGAACGCATGGT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSRRAVILAGGMGTRLRPYTVVLPKPLMPIGDYPILEVIIRQLISGGFQHITLAVNHQAELIKAFFQDGDKWGVRIDYSL
EDQPLGTMGPLRLIKDLPENFLVMNGDILTDLNYADFHDTHVREGNIFTISSKTREHRIDYGVLDTNEAGLLTGFREKPT
AEYKVSMGVYMVSSGAVEHIPQRGAYGFDQLMLDLLAAGKPATVRDFPGYWLDIGRPDDYALAIEQFETMQSRFLNG

Sequences:

>Translated_237_residues
MSRRAVILAGGMGTRLRPYTVVLPKPLMPIGDYPILEVIIRQLISGGFQHITLAVNHQAELIKAFFQDGDKWGVRIDYSL
EDQPLGTMGPLRLIKDLPENFLVMNGDILTDLNYADFHDTHVREGNIFTISSKTREHRIDYGVLDTNEAGLLTGFREKPT
AEYKVSMGVYMVSSGAVEHIPQRGAYGFDQLMLDLLAAGKPATVRDFPGYWLDIGRPDDYALAIEQFETMQSRFLNG
>Mature_236_residues
SRRAVILAGGMGTRLRPYTVVLPKPLMPIGDYPILEVIIRQLISGGFQHITLAVNHQAELIKAFFQDGDKWGVRIDYSLE
DQPLGTMGPLRLIKDLPENFLVMNGDILTDLNYADFHDTHVREGNIFTISSKTREHRIDYGVLDTNEAGLLTGFREKPTA
EYKVSMGVYMVSSGAVEHIPQRGAYGFDQLMLDLLAAGKPATVRDFPGYWLDIGRPDDYALAIEQFETMQSRFLNG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=228, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI11761619, Length=228, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI31881779, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI45447090, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788351, Length=244, Percent_Identity=24.1803278688525, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=235, Percent_Identity=33.6170212765957, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17509979, Length=194, Percent_Identity=30.4123711340206, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17509981, Length=179, Percent_Identity=28.4916201117318, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=229, Percent_Identity=32.7510917030568, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=33.920704845815, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=33.920704845815, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26579; Mature: 26448

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRAVILAGGMGTRLRPYTVVLPKPLMPIGDYPILEVIIRQLISGGFQHITLAVNHQAE
CCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHH
LIKAFFQDGDKWGVRIDYSLEDQPLGTMGPLRLIKDLPENFLVMNGDILTDLNYADFHDT
HHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCEEECCCCCCCCCC
HVREGNIFTISSKTREHRIDYGVLDTNEAGLLTGFREKPTAEYKVSMGVYMVSSGAVEHI
EECCCCEEEEECCCHHHCCCCCEECCCCCCEEECCCCCCCCEEEEEEEEEEECCCCHHHC
PQRGAYGFDQLMLDLLAAGKPATVRDFPGYWLDIGRPDDYALAIEQFETMQSRFLNG
CCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRRAVILAGGMGTRLRPYTVVLPKPLMPIGDYPILEVIIRQLISGGFQHITLAVNHQAE
CCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHH
LIKAFFQDGDKWGVRIDYSLEDQPLGTMGPLRLIKDLPENFLVMNGDILTDLNYADFHDT
HHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCEEECCCCCCCCCC
HVREGNIFTISSKTREHRIDYGVLDTNEAGLLTGFREKPTAEYKVSMGVYMVSSGAVEHI
EECCCCEEEEECCCHHHCCCCCEECCCCCCEEECCCCCCCCEEEEEEEEEEECCCCHHHC
PQRGAYGFDQLMLDLLAAGKPATVRDFPGYWLDIGRPDDYALAIEQFETMQSRFLNG
CCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA