Click here to switch to the map view.

The map label for this gene is argD [H]

Identifier: 209547784

GI number: 209547784

Start: 174340

End: 175539

Strand: Direct

Name: argD [H]

Synonym: Rleg2_0175

Alternate gene names: 209547784

Gene position: 174340-175539 (Clockwise)

Preceding gene: 209547782

Following gene: 209547785

Centisome position: 3.84

GC content: 66.58

Gene sequence:

>1200_bases
ATGGCTGAAGCCGCGCCGCTTTATGACACCTATTCTCGTGCCCCGCTGCGGTTCGAGCGAGGCGAGGGCGTATGGCTGAT
CACCGAAAGCGGCGAGCGTTATCTCGATTTCGGCGCCGGCGTCGCCGTCACCTCGGTCGGTCATAGCAACCCGCATGTGG
TTGGCGCCTTGAAGGAACAGGCCGACAAGGTCTGGCACCTCTCCAATATCTATGAGATCCCCGGCCAGGAGCGCCTGGCC
AAGCGGCTGACGGAAGCGACCTTCGCCGACAAGGTGTTCTTCACCAATTCGGGCGCCGAGGCGCTCGAATGCGCGATCAA
GACGGCGCGCCGCTACCAGTTTTCCAAGGGCCATCCCGAGCGCTTTCATATCATCACCTTCGAAGGCGCCTTCCATGGCC
GGACGCTCGCGACCATCGCCGCCGGCGGCCAGGAGAAATATCTCGAAGGTTTCGGCCCCAAGGCGCCGGGCTTCGATCAG
GTGGCCTTCGGCGACATCGACGCCGTCCGCGCCGCCATCACCGACGCGACGGCCGCAATCCTCATCGAGCCGGTGCAGGG
CGAGGGCGGCGTGCGCCCGGCCACGCCTGAGTTCATGAAGGCGCTGCGCCAGCTCTGCGACGAAAACGGCCTGCTGCTGA
TCCTCGACGAGGTCCAGACCGGGGTCGGCCGCACCGGCAAGCTTTTTGCCCATGAATGGTCGGGCATCACCCCCGATATC
ATGGCTGTCGCCAAGGGCATCGGCGGCGGTTTCCCGCTCGGCGCCTGTCTTGCCACGTCTGAGGCCGCCTCCGGCATGAA
GGCCGGCACGCACGGCTCGACTTATGGCGGCAATCCGCTCGCCATGGCCGTCGGCGGTGCCGTGCTCGACATCATCCTCG
CCGATGGCTTCCTCCAGCAGGTCCGCGACGTGGCACTCGTCTTCCGCCAGGGACTGGCCTCGCTGAAGGACCGCTATCCC
GATGTGATCGAGGATATCAGAGGCGAGGGGCTGCTGCTCGGCGTCAAGGCGGCCGTTCCTTCAGCCGACCTGCTGCAGGC
GATCCGCGCCGCGCATCTGCTCGGCGTGCCCGCCGGCGACAACGTCATCCGCCTTCTTCCGCCCCTCGTCGTCACCGCCG
AGGAAGCCCGCGAGGGCCTTGCCCGCATCGAGCGCGCCGCCGAGAGCATCCGCGCCTCCAAGGTCAAGAAGACGGCTTGA

Upstream 100 bases:

>100_bases
AGTACCGCTGGCCGCCGCAAGGCGGCATTTTTGATTTTTCGGGCCTGGTTTTCTTAGCCGGAGTCCTGTGTTTGACAACG
CTGATCGGGAGACCCGCGCC

Downstream 100 bases:

>100_bases
AAGGATTGTGCCTGCGGGCGCACGACAGGTAAGAACATGGCTCCTAAACATTTCCTCGATCTTTCGGCCGTCACCTCAGC
CGACCTCAGAACCATCATGA

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAEAAPLYDTYSRAPLRFERGEGVWLITESGERYLDFGAGVAVTSVGHSNPHVVGALKEQADKVWHLSNIYEIPGQERLA
KRLTEATFADKVFFTNSGAEALECAIKTARRYQFSKGHPERFHIITFEGAFHGRTLATIAAGGQEKYLEGFGPKAPGFDQ
VAFGDIDAVRAAITDATAAILIEPVQGEGGVRPATPEFMKALRQLCDENGLLLILDEVQTGVGRTGKLFAHEWSGITPDI
MAVAKGIGGGFPLGACLATSEAASGMKAGTHGSTYGGNPLAMAVGGAVLDIILADGFLQQVRDVALVFRQGLASLKDRYP
DVIEDIRGEGLLLGVKAAVPSADLLQAIRAAHLLGVPAGDNVIRLLPPLVVTAEEAREGLARIERAAESIRASKVKKTA

Sequences:

>Translated_399_residues
MAEAAPLYDTYSRAPLRFERGEGVWLITESGERYLDFGAGVAVTSVGHSNPHVVGALKEQADKVWHLSNIYEIPGQERLA
KRLTEATFADKVFFTNSGAEALECAIKTARRYQFSKGHPERFHIITFEGAFHGRTLATIAAGGQEKYLEGFGPKAPGFDQ
VAFGDIDAVRAAITDATAAILIEPVQGEGGVRPATPEFMKALRQLCDENGLLLILDEVQTGVGRTGKLFAHEWSGITPDI
MAVAKGIGGGFPLGACLATSEAASGMKAGTHGSTYGGNPLAMAVGGAVLDIILADGFLQQVRDVALVFRQGLASLKDRYP
DVIEDIRGEGLLLGVKAAVPSADLLQAIRAAHLLGVPAGDNVIRLLPPLVVTAEEAREGLARIERAAESIRASKVKKTA
>Mature_398_residues
AEAAPLYDTYSRAPLRFERGEGVWLITESGERYLDFGAGVAVTSVGHSNPHVVGALKEQADKVWHLSNIYEIPGQERLAK
RLTEATFADKVFFTNSGAEALECAIKTARRYQFSKGHPERFHIITFEGAFHGRTLATIAAGGQEKYLEGFGPKAPGFDQV
AFGDIDAVRAAITDATAAILIEPVQGEGGVRPATPEFMKALRQLCDENGLLLILDEVQTGVGRTGKLFAHEWSGITPDIM
AVAKGIGGGFPLGACLATSEAASGMKAGTHGSTYGGNPLAMAVGGAVLDIILADGFLQQVRDVALVFRQGLASLKDRYPD
VIEDIRGEGLLLGVKAAVPSADLLQAIRAAHLLGVPAGDNVIRLLPPLVVTAEEAREGLARIERAAESIRASKVKKTA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=389, Percent_Identity=32.6478149100257, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI284507298, Length=302, Percent_Identity=33.7748344370861, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI13994255, Length=432, Percent_Identity=30.0925925925926, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=30.1401869158879, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=29.1079812206573, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI24119277, Length=432, Percent_Identity=26.1574074074074, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI188536080, Length=418, Percent_Identity=24.4019138755981, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI38679950, Length=418, Percent_Identity=24.4019138755981, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI38679946, Length=418, Percent_Identity=24.4019138755981, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=44.987146529563, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788044, Length=382, Percent_Identity=45.8115183246073, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI145693181, Length=387, Percent_Identity=36.4341085271318, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=33.9066339066339, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1787560, Length=387, Percent_Identity=35.6589147286822, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=31.8072289156626, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1786349, Length=313, Percent_Identity=31.629392971246, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=387, Percent_Identity=33.0749354005168, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32564660, Length=440, Percent_Identity=31.8181818181818, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=282, Percent_Identity=34.3971631205674, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=427, Percent_Identity=26.2295081967213, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=285, Percent_Identity=28.0701754385965, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=163, Percent_Identity=30.0613496932515, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=407, Percent_Identity=36.6093366093366, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6323470, Length=401, Percent_Identity=32.1695760598504, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324386, Length=394, Percent_Identity=24.8730964467005, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=361, Percent_Identity=26.0387811634349, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=32.0413436692506, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=31.9347319347319, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574759, Length=420, Percent_Identity=31.9047619047619, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=425, Percent_Identity=29.1764705882353, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281366494, Length=302, Percent_Identity=28.476821192053, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667139, Length=302, Percent_Identity=28.476821192053, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667143, Length=302, Percent_Identity=28.476821192053, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42310; Mature: 42179

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAAPLYDTYSRAPLRFERGEGVWLITESGERYLDFGAGVAVTSVGHSNPHVVGALKEQ
CCCCCCCHHHHCCCCEEEECCCEEEEEECCCCEEEECCCCEEEEECCCCCCCEEEHHHHH
ADKVWHLSNIYEIPGQERLAKRLTEATFADKVFFTNSGAEALECAIKTARRYQFSKGHPE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCC
RFHIITFEGAFHGRTLATIAAGGQEKYLEGFGPKAPGFDQVAFGDIDAVRAAITDATAAI
EEEEEEEECCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHCCEEE
LIEPVQGEGGVRPATPEFMKALRQLCDENGLLLILDEVQTGVGRTGKLFAHEWSGITPDI
EEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEECCCCCCHHH
MAVAKGIGGGFPLGACLATSEAASGMKAGTHGSTYGGNPLAMAVGGAVLDIILADGFLQQ
HHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VRDVALVFRQGLASLKDRYPDVIEDIRGEGLLLGVKAAVPSADLLQAIRAAHLLGVPAGD
HHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
NVIRLLPPLVVTAEEAREGLARIERAAESIRASKVKKTA
CHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEAAPLYDTYSRAPLRFERGEGVWLITESGERYLDFGAGVAVTSVGHSNPHVVGALKEQ
CCCCCCHHHHCCCCEEEECCCEEEEEECCCCEEEECCCCEEEEECCCCCCCEEEHHHHH
ADKVWHLSNIYEIPGQERLAKRLTEATFADKVFFTNSGAEALECAIKTARRYQFSKGHPE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCC
RFHIITFEGAFHGRTLATIAAGGQEKYLEGFGPKAPGFDQVAFGDIDAVRAAITDATAAI
EEEEEEEECCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHCCEEE
LIEPVQGEGGVRPATPEFMKALRQLCDENGLLLILDEVQTGVGRTGKLFAHEWSGITPDI
EEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEECCCCCCHHH
MAVAKGIGGGFPLGACLATSEAASGMKAGTHGSTYGGNPLAMAVGGAVLDIILADGFLQQ
HHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VRDVALVFRQGLASLKDRYPDVIEDIRGEGLLLGVKAAVPSADLLQAIRAAHLLGVPAGD
HHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
NVIRLLPPLVVTAEEAREGLARIERAAESIRASKVKKTA
CHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]