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The map label for this gene is pyrC [H]

Identifier: 209547740

GI number: 209547740

Start: 121254

End: 122294

Strand: Direct

Name: pyrC [H]

Synonym: Rleg2_0129

Alternate gene names: 209547740

Gene position: 121254-122294 (Clockwise)

Preceding gene: 209547739

Following gene: 209547741

Centisome position: 2.67

GC content: 63.88

Gene sequence:

>1041_bases
ATGCAATCGATCACCATCCGCCGCCCTGACGACTGGCACCTGCATCTGCGCGATGGCGCGATGCTCGAAGGCGTGATCGC
CGATACGAGCCGCACCTTCGCCCGCGCCATCATCATGCCCAATCTCGTGCCGCCCGTCGTCACCACGTCGGATGCGACGG
CCTATCGCGAGCGCATTCTGAAGGCGCTGCCGGCCGGCCATCGTTTCCAGCCGCTGATGACGCTTTATCTCACCGAGCAT
ACCAGCCCCGACGATGTCGAAGCCGGTGCCAGGAGCGGCCTCATCACTGCCGTCAAGCTTTATCCGGCCGGCGCCACCAC
CAATTCGCATGGCGGCGTCCGCGACATGGAAAAGGCGATGCCGGTGCTGGAGCGCATGGCTGCGATTGGCCTGCCGCTCT
GCGTCCATGGCGAAGTGACGACGCCTGAGGTCGATATCTTCGATCGCGAAGCCGTCTTCATCGATACCGTGCTCGATCCG
CTGCGCCGGCGCCTGCCGGAGCTGAAGGTGACGATGGAGCATGTGACGACATCGGACGGTATCGACTACATCAAGGCGGC
CAAGGCCAATCTTGCCGGCTCGATCACCAGCCATCATCTCATCATCAACCGCAACGCCATCCTCGTCGGCGGTATCCGCC
CGCATTATTATTGCCTGCCGGTCGCCAAGCGCGAGAACCATCGGTTGGCGCTGCGCGCCGCCGCCGTGAGCGGTGACGCC
CGCTTCTTCCTCGGCACCGATTCCGCCCCGCATGTCGACCCGCTGAAGGAATGCGCCTGCGGCTGCGCCGGCATCTACAC
CTCGATCAACACGATGAGCTGCCTTGCGCATGTCTTCGAGGAGGAGGACGCGCTGGACAGGCTCGAAGCCTTCACCTCGC
TGAACGGACCGGCCTGGTACGGGCTTCAGCCGAACGAGGAGCGCATCACCCTGTCCAGGCAGGCCGAGCCGGTCGTTTTT
CCCGCCAAGATAGAAACCGGCGCCGGTTCGGTGACGGTGTTCGATCCGATGTATCCGCTGCATTGGCACGTTGTGGCGTA
G

Upstream 100 bases:

>100_bases
AATCAAGTTTGATGCGACGCGCTCTAATGCCGCGACGATTGTTTTCACCTGAGGTATAGTGCTATTCGAGGCCGCAGACG
CATCGCTTCGGAGGCCTGCC

Downstream 100 bases:

>100_bases
GTGCTGCGGCCCCGTTATCAATTTTAAATAGAATATTCATTAAAGTTGTGCGCCGACGTTAGGCGCATAACATTTTCTTT
GTGCAATGCATCATTTGTTA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MQSITIRRPDDWHLHLRDGAMLEGVIADTSRTFARAIIMPNLVPPVVTTSDATAYRERILKALPAGHRFQPLMTLYLTEH
TSPDDVEAGARSGLITAVKLYPAGATTNSHGGVRDMEKAMPVLERMAAIGLPLCVHGEVTTPEVDIFDREAVFIDTVLDP
LRRRLPELKVTMEHVTTSDGIDYIKAAKANLAGSITSHHLIINRNAILVGGIRPHYYCLPVAKRENHRLALRAAAVSGDA
RFFLGTDSAPHVDPLKECACGCAGIYTSINTMSCLAHVFEEEDALDRLEAFTSLNGPAWYGLQPNEERITLSRQAEPVVF
PAKIETGAGSVTVFDPMYPLHWHVVA

Sequences:

>Translated_346_residues
MQSITIRRPDDWHLHLRDGAMLEGVIADTSRTFARAIIMPNLVPPVVTTSDATAYRERILKALPAGHRFQPLMTLYLTEH
TSPDDVEAGARSGLITAVKLYPAGATTNSHGGVRDMEKAMPVLERMAAIGLPLCVHGEVTTPEVDIFDREAVFIDTVLDP
LRRRLPELKVTMEHVTTSDGIDYIKAAKANLAGSITSHHLIINRNAILVGGIRPHYYCLPVAKRENHRLALRAAAVSGDA
RFFLGTDSAPHVDPLKECACGCAGIYTSINTMSCLAHVFEEEDALDRLEAFTSLNGPAWYGLQPNEERITLSRQAEPVVF
PAKIETGAGSVTVFDPMYPLHWHVVA
>Mature_346_residues
MQSITIRRPDDWHLHLRDGAMLEGVIADTSRTFARAIIMPNLVPPVVTTSDATAYRERILKALPAGHRFQPLMTLYLTEH
TSPDDVEAGARSGLITAVKLYPAGATTNSHGGVRDMEKAMPVLERMAAIGLPLCVHGEVTTPEVDIFDREAVFIDTVLDP
LRRRLPELKVTMEHVTTSDGIDYIKAAKANLAGSITSHHLIINRNAILVGGIRPHYYCLPVAKRENHRLALRAAAVSGDA
RFFLGTDSAPHVDPLKECACGCAGIYTSINTMSCLAHVFEEEDALDRLEAFTSLNGPAWYGLQPNEERITLSRQAEPVVF
PAKIETGAGSVTVFDPMYPLHWHVVA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=317, Percent_Identity=56.1514195583596, Blast_Score=370, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323452, Length=370, Percent_Identity=34.0540540540541, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37931; Mature: 37931

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSITIRRPDDWHLHLRDGAMLEGVIADTSRTFARAIIMPNLVPPVVTTSDATAYRERIL
CCCEEEECCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
KALPAGHRFQPLMTLYLTEHTSPDDVEAGARSGLITAVKLYPAGATTNSHGGVRDMEKAM
HHCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHH
PVLERMAAIGLPLCVHGEVTTPEVDIFDREAVFIDTVLDPLRRRLPELKVTMEHVTTSDG
HHHHHHHHHCCCEEEECCCCCCCEEEECCCEEHHHHHHHHHHHHCCHHEEEHHHHCCCCC
IDYIKAAKANLAGSITSHHLIINRNAILVGGIRPHYYCLPVAKRENHRLALRAAAVSGDA
HHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCEEEEECCCCCCCEEEEEEEEECCCE
RFFLGTDSAPHVDPLKECACGCAGIYTSINTMSCLAHVFEEEDALDRLEAFTSLNGPAWY
EEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
GLQPNEERITLSRQAEPVVFPAKIETGAGSVTVFDPMYPLHWHVVA
CCCCCCCEEEEECCCCCEEEEEEEECCCCCEEEECCCCCCEEEEEC
>Mature Secondary Structure
MQSITIRRPDDWHLHLRDGAMLEGVIADTSRTFARAIIMPNLVPPVVTTSDATAYRERIL
CCCEEEECCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
KALPAGHRFQPLMTLYLTEHTSPDDVEAGARSGLITAVKLYPAGATTNSHGGVRDMEKAM
HHCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHH
PVLERMAAIGLPLCVHGEVTTPEVDIFDREAVFIDTVLDPLRRRLPELKVTMEHVTTSDG
HHHHHHHHHCCCEEEECCCCCCCEEEECCCEEHHHHHHHHHHHHCCHHEEEHHHHCCCCC
IDYIKAAKANLAGSITSHHLIINRNAILVGGIRPHYYCLPVAKRENHRLALRAAAVSGDA
HHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCEEEEECCCCCCCEEEEEEEEECCCE
RFFLGTDSAPHVDPLKECACGCAGIYTSINTMSCLAHVFEEEDALDRLEAFTSLNGPAWY
EEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
GLQPNEERITLSRQAEPVVFPAKIETGAGSVTVFDPMYPLHWHVVA
CCCCCCCEEEEECCCCCEEEEEEEECCCCCEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA