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The map label for this gene is qor [C]

Identifier: 209547723

GI number: 209547723

Start: 104569

End: 105573

Strand: Direct

Name: qor [C]

Synonym: Rleg2_0112

Alternate gene names: 209547723

Gene position: 104569-105573 (Clockwise)

Preceding gene: 209547722

Following gene: 209547724

Centisome position: 2.3

GC content: 59.6

Gene sequence:

>1005_bases
ATGAAGGCATTCGTCGTTGATAAGTACAAAAAGAAGGGCGCTTTGCGCCTGGCCAGCCTGCCGGAACCGGAATTGCAGGA
CAATGATGTCCTTGTCCGGGTTCAGGCTACGGCCGTAAACCTTCTGGACTCCAAGCTGCGGGACGGAGAGTTCAAGCTCA
TTCTTCCCTATCGTCCGCCCTTCGTCCTCGGCCACGACGTTGCCGGAACAGTTGTTAGGGCGGGACCGAGGGTCAGGCGG
CTCAAGGTGGGTGACGAGGTCTACGCACGGCCGCGCGATCATCGGGTCGGCACATTCGCCGAATTCATCGCCATCGATGA
AGCCGATTTGGCGCTGAAACCGAACAACCTCAGCATGGCCGAAGCGGCGTCCATCCCCCTGGTGGGGCTAACCGCGTGGC
AGGCGCTGGTCGAGGTGGGCAAGGTGAAGCCCGGCCAGAAGGTCTTCATTCAGGCCGGTTCCGGCGGTGTCGGGACTTTC
GCCATTCAGCTCGCCAAGCATCTTGGCGCGATGGTGGCGACGACGACCAGCGCTGGAAATGCCGAGCTCGCCAAAAGTCT
CGGGGCGGATGTGATTGTCGACTACAAGAGCCAGGATTTTGAGAAGGTCTTGTCGGGCTATGATCTGGTGCTGAACAGTC
AGGATCCGAAGACGCTTGAAAAATCACTGGCTGTGCTGAAGCCGGGTGGCCGGCTCATCTCCATTTCCGGTCCGCCCGAT
CCTGCTTTCGCCAGGGAACTCGGCCTGAACCTGTTTCTGAAACTGGTGCTGCGCTTGCTGAGCCGAGGGGTTCGGAAAAA
GGCCAAGCGTCTAGGCATAGGCTATTCATTCCTGTTCATGCGCGCCGAGGGGCGGCAGTTGAATGAGATCACGCGCCTGA
TCGAACAAGGCGCGATCCGGCCGGTCGTCGACAAGGTCTTCCCGTTTGAAAAAACCGGCGATGCGCTGGCTTATGTCGAG
ACCGGGCGTGCAAAGGGCAAGGTGGTCATCACGGTCGCAGACTGA

Upstream 100 bases:

>100_bases
ACATGGCGGGATCTTCCAGAACCACGCCGATTTCGTGCCGAAGGCTTTGTCCTTCCTTGCAGCCTGACATCCCACCAGAC
TTCGAATTGGAGAAAGCCTC

Downstream 100 bases:

>100_bases
GGTCGACCTGACCGACGCGGCGTGCGTTGCGAGACGAACGCGAGAAATAATTCCAACTCTGAAAGCGAAAAATGACCAGC
AAGACACTCTTTGAACCCTT

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKAFVVDKYKKKGALRLASLPEPELQDNDVLVRVQATAVNLLDSKLRDGEFKLILPYRPPFVLGHDVAGTVVRAGPRVRR
LKVGDEVYARPRDHRVGTFAEFIAIDEADLALKPNNLSMAEAASIPLVGLTAWQALVEVGKVKPGQKVFIQAGSGGVGTF
AIQLAKHLGAMVATTTSAGNAELAKSLGADVIVDYKSQDFEKVLSGYDLVLNSQDPKTLEKSLAVLKPGGRLISISGPPD
PAFARELGLNLFLKLVLRLLSRGVRKKAKRLGIGYSFLFMRAEGRQLNEITRLIEQGAIRPVVDKVFPFEKTGDALAYVE
TGRAKGKVVITVAD

Sequences:

>Translated_334_residues
MKAFVVDKYKKKGALRLASLPEPELQDNDVLVRVQATAVNLLDSKLRDGEFKLILPYRPPFVLGHDVAGTVVRAGPRVRR
LKVGDEVYARPRDHRVGTFAEFIAIDEADLALKPNNLSMAEAASIPLVGLTAWQALVEVGKVKPGQKVFIQAGSGGVGTF
AIQLAKHLGAMVATTTSAGNAELAKSLGADVIVDYKSQDFEKVLSGYDLVLNSQDPKTLEKSLAVLKPGGRLISISGPPD
PAFARELGLNLFLKLVLRLLSRGVRKKAKRLGIGYSFLFMRAEGRQLNEITRLIEQGAIRPVVDKVFPFEKTGDALAYVE
TGRAKGKVVITVAD
>Mature_334_residues
MKAFVVDKYKKKGALRLASLPEPELQDNDVLVRVQATAVNLLDSKLRDGEFKLILPYRPPFVLGHDVAGTVVRAGPRVRR
LKVGDEVYARPRDHRVGTFAEFIAIDEADLALKPNNLSMAEAASIPLVGLTAWQALVEVGKVKPGQKVFIQAGSGGVGTF
AIQLAKHLGAMVATTTSAGNAELAKSLGADVIVDYKSQDFEKVLSGYDLVLNSQDPKTLEKSLAVLKPGGRLISISGPPD
PAFARELGLNLFLKLVLRLLSRGVRKKAKRLGIGYSFLFMRAEGRQLNEITRLIEQGAIRPVVDKVFPFEKTGDALAYVE
TGRAKGKVVITVAD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=361, Percent_Identity=35.4570637119114, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI22538446, Length=357, Percent_Identity=28.8515406162465, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI22538444, Length=357, Percent_Identity=28.8515406162465, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI18379349, Length=317, Percent_Identity=27.7602523659306, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI41872631, Length=236, Percent_Identity=33.8983050847458, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI194239674, Length=352, Percent_Identity=26.7045454545455, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13236495, Length=352, Percent_Identity=26.7045454545455, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI24308257, Length=349, Percent_Identity=25.7879656160458, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI194239676, Length=337, Percent_Identity=26.1127596439169, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI28557745, Length=229, Percent_Identity=31.8777292576419, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI90669511, Length=157, Percent_Identity=33.1210191082803, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1790485, Length=231, Percent_Identity=29.8701298701299, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790045, Length=272, Percent_Identity=27.5735294117647, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71987554, Length=370, Percent_Identity=29.4594594594595, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17507255, Length=345, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=26.9406392694064, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=270, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=263, Percent_Identity=28.8973384030418, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=218, Percent_Identity=28.8990825688073, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI212642053, Length=236, Percent_Identity=31.3559322033898, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=282, Percent_Identity=27.6595744680851, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=346, Percent_Identity=26.878612716763, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324195, Length=265, Percent_Identity=30.188679245283, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24581341, Length=363, Percent_Identity=28.9256198347107, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24581339, Length=363, Percent_Identity=28.9256198347107, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19920632, Length=236, Percent_Identity=32.2033898305085, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330659, Length=236, Percent_Identity=32.2033898305085, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581345, Length=232, Percent_Identity=31.4655172413793, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36165; Mature: 36165

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFVVDKYKKKGALRLASLPEPELQDNDVLVRVQATAVNLLDSKLRDGEFKLILPYRPP
CCCEEEEHHHCCCCEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEEECCCCC
FVLGHDVAGTVVRAGPRVRRLKVGDEVYARPRDHRVGTFAEFIAIDEADLALKPNNLSMA
EEECCCCCCHHHHCCCCEEEEEECCHHHCCCCCCCCCHHHHHEEECCCCEEECCCCCCHH
EAASIPLVGLTAWQALVEVGKVKPGQKVFIQAGSGGVGTFAIQLAKHLGAMVATTTSAGN
HHCCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCC
AELAKSLGADVIVDYKSQDFEKVLSGYDLVLNSQDPKTLEKSLAVLKPGGRLISISGPPD
HHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCCCHHHHHHHHHEECCCCEEEEECCCCC
PAFARELGLNLFLKLVLRLLSRGVRKKAKRLGIGYSFLFMRAEGRQLNEITRLIEQGAIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCC
PVVDKVFPFEKTGDALAYVETGRAKGKVVITVAD
HHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEEC
>Mature Secondary Structure
MKAFVVDKYKKKGALRLASLPEPELQDNDVLVRVQATAVNLLDSKLRDGEFKLILPYRPP
CCCEEEEHHHCCCCEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEEECCCCC
FVLGHDVAGTVVRAGPRVRRLKVGDEVYARPRDHRVGTFAEFIAIDEADLALKPNNLSMA
EEECCCCCCHHHHCCCCEEEEEECCHHHCCCCCCCCCHHHHHEEECCCCEEECCCCCCHH
EAASIPLVGLTAWQALVEVGKVKPGQKVFIQAGSGGVGTFAIQLAKHLGAMVATTTSAGN
HHCCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCC
AELAKSLGADVIVDYKSQDFEKVLSGYDLVLNSQDPKTLEKSLAVLKPGGRLISISGPPD
HHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCCCHHHHHHHHHEECCCCEEEEECCCCC
PAFARELGLNLFLKLVLRLLSRGVRKKAKRLGIGYSFLFMRAEGRQLNEITRLIEQGAIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCC
PVVDKVFPFEKTGDALAYVETGRAKGKVVITVAD
HHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]