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The map label for this gene is lspA [H]

Identifier: 209547649

GI number: 209547649

Start: 40259

End: 40762

Strand: Reverse

Name: lspA [H]

Synonym: Rleg2_0037

Alternate gene names: 209547649

Gene position: 40762-40259 (Counterclockwise)

Preceding gene: 209547650

Following gene: 209547648

Centisome position: 0.9

GC content: 60.32

Gene sequence:

>504_bases
ATGACCGAACTGACGCCTGCCCGCCCCGCGCTGTTTTCGCGCCCCGCGCCCATCCTCTTCTTCATCATCGTCGCCGTTCT
CCTCGACCAAATCGTCAAGATCGCTGTCGATCATTACCTGCCGCTGCAGGAGGCCGTGCCGGTTGTTCCGATGCTGGCGC
TCTACCGCACCTATAATCTCGGCGTCGCCTTTTCGATGCTGGAGGGCATGGATGGCTGGTTCATCGTCGGCATGCGGCTG
ATCATCGTCGCCTTCGTCATCTGGCTGTGGTACCGCACGGCGAAAGACCGCTGGCTCGCTCATCTCGGTTACGCGCTGAT
CATCGCCGGCGCGATCGGCAATCTCGTCGACCGCTTCGCCTATGGCCACGTGATCGATTACATCCTGTTTTACACCGACA
GCTGGTCTTTCGCGGTGTTCAATCTCGCCGACAGTTTCATCACCATCGGGGCTGGCTGCGTCATTCTCGACGAGCTGCTG
CTGCCGAAAAAGGCCGGCCGCTAA

Upstream 100 bases:

>100_bases
TTCCCCAGCAGGGCCGCGCCGATTCCCTGAACCTCGCCGTCGCCACCGCCGTCATGCTTTTCGAGGCGCGCCGCCATCTC
CTCTCACTTGCCGAGGGCAA

Downstream 100 bases:

>100_bases
AATCTTATCGAATTCCTGAAGGCATTCGGAAGAGGCCTCATGTTAGCCAGATTGCATGCACAATCTGGGACAGTTGCAGG
AAAGATTGTCCGCCGCCTTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTELTPARPALFSRPAPILFFIIVAVLLDQIVKIAVDHYLPLQEAVPVVPMLALYRTYNLGVAFSMLEGMDGWFIVGMRL
IIVAFVIWLWYRTAKDRWLAHLGYALIIAGAIGNLVDRFAYGHVIDYILFYTDSWSFAVFNLADSFITIGAGCVILDELL
LPKKAGR

Sequences:

>Translated_167_residues
MTELTPARPALFSRPAPILFFIIVAVLLDQIVKIAVDHYLPLQEAVPVVPMLALYRTYNLGVAFSMLEGMDGWFIVGMRL
IIVAFVIWLWYRTAKDRWLAHLGYALIIAGAIGNLVDRFAYGHVIDYILFYTDSWSFAVFNLADSFITIGAGCVILDELL
LPKKAGR
>Mature_166_residues
TELTPARPALFSRPAPILFFIIVAVLLDQIVKIAVDHYLPLQEAVPVVPMLALYRTYNLGVAFSMLEGMDGWFIVGMRLI
IVAFVIWLWYRTAKDRWLAHLGYALIIAGAIGNLVDRFAYGHVIDYILFYTDSWSFAVFNLADSFITIGAGCVILDELLL
PKKAGR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=152, Percent_Identity=38.1578947368421, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18768; Mature: 18636

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTPARPALFSRPAPILFFIIVAVLLDQIVKIAVDHYLPLQEAVPVVPMLALYRTYNL
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GVAFSMLEGMDGWFIVGMRLIIVAFVIWLWYRTAKDRWLAHLGYALIIAGAIGNLVDRFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGHVIDYILFYTDSWSFAVFNLADSFITIGAGCVILDELLLPKKAGR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TELTPARPALFSRPAPILFFIIVAVLLDQIVKIAVDHYLPLQEAVPVVPMLALYRTYNL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GVAFSMLEGMDGWFIVGMRLIIVAFVIWLWYRTAKDRWLAHLGYALIIAGAIGNLVDRFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGHVIDYILFYTDSWSFAVFNLADSFITIGAGCVILDELLLPKKAGR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]