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The map label for this gene is gabT1 [H]

Identifier: 209400873

GI number: 209400873

Start: 1840373

End: 1841638

Strand: Direct

Name: gabT1 [H]

Synonym: ECH74115_1944

Alternate gene names: 209400873

Gene position: 1840373-1841638 (Clockwise)

Preceding gene: 209396047

Following gene: 209399315

Centisome position: 33.03

GC content: 57.9

Gene sequence:

>1266_bases
ATGAGCAACAATGAATTCCATCAGCGTCGTCTTTCTGCCACCCCGCGCGGGGTTGGCGTGATGTGTAACTTCTTCGCCCA
GTCGGCTGAAAACGCCACGCTGAAGGATGTTGAGGGCAACGAGTACATCGATTTCGCCGCAGGCATTGCGGTGCTGAATA
CCGGACATCGCCACCCTGATCTGGTCGCGGCGGTGGAGCAGCAGCTGCAACAGTTTACCCACACCGCGTATCAGATTGTG
CCATATGAAAGCTACGTCACCCTGGCGGAGAAAATCAACGCCCTTGCCCCGGTGAGCGGGCAGGCCAAAACCGCGTTCTT
CACCACCGGTGCGGAAGCGGTGGAAAACGCGGTGAAAATCGCCCGCGCCCATACCGGACGCCCTGGCGTGATTGCGTTTA
GCGGCGGCTTCCACGGTCGTACGTATATGACTATGGCGTTAACTGGAAAGGTCGCGCCGTACAAAATCGGCTTCGGCCCG
TTCCCTGGTTCGGTGTATCACGTACCTTATCCGTCAGATTTACACGGCATTTCAACACAGGACTCCCTCGACGCCATCGA
ACGCTTGTTTAAATCAGACATCGAAGCGAAGCAGGTCGCGGCCATTATTTTCGAACCGGTGCAGGGCGAGGGCGGTTTCA
ACGTTGCGCCAAAAGAGCTGGTTGCCGCCATTCGCCGCCTGTGCGACGAGCACGGTATTGTGATGATTGCCGATGAAGTG
CAAAGCGGCTTTGCGCGTACCGGCAAACTGTTTGCGATGGATCATTACGCCGATAAGCCGGACTTAATGACGATGGCGAA
AAGCCTCGCGGGCGGGATGCCGCTTTCGGGTGTGGTCGGTAACGCGAATATTATGGACGCGCCCGCGCCGGGCGGGCTTG
GCGGCACCTACGCCGGGAATCCGCTGGCGGTGGCTGCCGCGCACGCGGTGCTCAACATTATCGACAAAGAGTCACTCTGT
GAGCGCGCCATGCAGTTGGGGCAGCGTCTGACGAAAACCCTGATTGATGCCAAAGAAAACGTTCCGGCCATCGCGGCGGT
ACGTGGTCTGGGCTCGATGATTGCGGCAGAATTTAACGACCCGCAAACGGGCGAGCCGTCAGCCGCCATTGCGCAAAAAA
TTCAGCAACGCGCGCTGGCGCAGGGACTGCTTCTACTGACCTGTGGCGCATACGGCAACGTGATTCGTTTCCTGTATCCG
CTGACCATCCCGGATGCGCAATTCGATGCGGCAATGAAAATTTTGCAGGATGCGCTGAGAGATTAA

Upstream 100 bases:

>100_bases
CGCGTACCGTTTACCGCGATGGGCGCGGCGTATTACAGCCTGCGCGATCGTCTGGGCGTTTAATTTCCGATTAACAGTGA
AGAGTCAAAAGGTGTGAAAC

Downstream 100 bases:

>100_bases
TACGCAGAAGCAGGGGCAACGCAATAATGCCTGATATGCTGCGCTTATCAGACCTGCAAACGACGTATTGATTATGTATG
CCGGATAAGGCGTTCACGCC

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
ERAMQLGQRLTKTLIDAKENVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALRD

Sequences:

>Translated_421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
ERAMQLGQRLTKTLIDAKENVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALRD
>Mature_420_residues
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIVP
YESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPF
PGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEVQ
SGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLCE
RAMQLGQRLTKTLIDAKENVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPL
TIPDAQFDAAMKILQDALRD

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=32.25, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=32.2981366459627, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI13994255, Length=416, Percent_Identity=30.2884615384615, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI37574042, Length=448, Percent_Identity=29.0178571428571, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI188536080, Length=445, Percent_Identity=28.314606741573, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI38679950, Length=445, Percent_Identity=28.314606741573, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI38679946, Length=445, Percent_Identity=28.314606741573, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=30.0771208226221, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=416, Percent_Identity=26.9230769230769, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI226442705, Length=448, Percent_Identity=28.5714285714286, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=98.5748218527316, Blast_Score=850, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=54.3942992874109, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=33.4987593052109, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788044, Length=390, Percent_Identity=34.6153846153846, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=35.0746268656716, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=31.6091954022989, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786991, Length=409, Percent_Identity=27.8728606356968, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=32.9238329238329, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32564660, Length=422, Percent_Identity=31.9905213270142, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=405, Percent_Identity=30.6172839506173, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=32.5423728813559, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=427, Percent_Identity=25.5269320843091, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=32.7586206896552, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=31.5270935960591, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=25.1592356687898, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=26.8817204301075, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=31.6831683168317, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI161085790, Length=418, Percent_Identity=29.9043062200957, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28574759, Length=408, Percent_Identity=30.8823529411765, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=28.4382284382284, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI281366494, Length=364, Percent_Identity=26.9230769230769, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24667139, Length=364, Percent_Identity=26.9230769230769, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24667143, Length=364, Percent_Identity=26.9230769230769, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 44802; Mature: 44671

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCH
DSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCERAMQLGQRLTKTLIDAKENVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALR
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C
>Mature Secondary Structure 
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCH
DSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCERAMQLGQRLTKTLIDAKENVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALR
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]