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The map label for this gene is xdhC

Identifier: 209400478

GI number: 209400478

Start: 3846217

End: 3846696

Strand: Direct

Name: xdhC

Synonym: ECH74115_4158

Alternate gene names: 209400478

Gene position: 3846217-3846696 (Clockwise)

Preceding gene: 209397706

Following gene: 209398899

Centisome position: 69.03

GC content: 52.08

Gene sequence:

>480_bases
ATGAATCACAGCGAAACAATTACCATCGAATGCACCATTAACGGGATGCCTTTTCAGCTTCATGCCGTACCAGGCACGCC
GCTCTCGGAATTACTCCGCGAACAAGGGCTGCTAAGTGTCAAACAAGGGTGCTGCGTGGGTGAATGTGGTGCCTGTACGG
TGCTGGTCGACGGCACAGCAATAGACAGTTGCTTATACCTTGCCGCCTGGGCTGAAGGAAAAGAGATCCGCACGCTGGAA
GGTGAAGCGAAAGGCGGAAAACTTTCTCATGTTCAGCAGGCTTATGCGAAATCCGGCGCAGTGCAGTGCGGGTTTTGTAC
GCCTGGCCTGATTATGGCTACCACGGCAATGCTGGCGAAACCACGCGAGAAGCCATTAACCATTACGGAAATTCGTCGCG
GACTGGCGGGAAATCTTTGTCGCTGCACGGGGTATCAGATGATTGTAAATACAGTTCTGGATTGCGAGAAAACGAAGTAA

Upstream 100 bases:

>100_bases
CTTCATGGCGGGCCAGTAAAGAGTTTCGTCTGCATCTCATCCAGACGATGACCAAAAAAGTGATTAGCGAAGCCGTCGCC
GCGGCGGGGGGAAAATTGCA

Downstream 100 bases:

>100_bases
AAGGATATCCGGCCTGAATTCAGGCCGGATTCACTGATGTTATGTGTTTAACAACTCATATTTCTTAATCTTGCGATAGA
GCGTAGCAATGCCGATGCCC

Product: xanthine dehydrogenase subunit XdhC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MNHSETITIECTINGMPFQLHAVPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTAIDSCLYLAAWAEGKEIRTLE
GEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAKPREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK

Sequences:

>Translated_159_residues
MNHSETITIECTINGMPFQLHAVPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTAIDSCLYLAAWAEGKEIRTLE
GEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAKPREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK
>Mature_159_residues
MNHSETITIECTINGMPFQLHAVPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTAIDSCLYLAAWAEGKEIRTLE
GEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAKPREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK

Specific function: Iron-sulfur subunit of the xanthine dehydrogenase complex

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain

Homologues:

Organism=Escherichia coli, GI1789232, Length=159, Percent_Identity=99.3710691823899, Blast_Score=323, Evalue=4e-90,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=35.9756097560976, Blast_Score=98, Evalue=2e-22,
Organism=Escherichia coli, GI1789246, Length=141, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540638, Length=138, Percent_Identity=40.5797101449275, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17539860, Length=153, Percent_Identity=34.640522875817, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI32566215, Length=141, Percent_Identity=34.7517730496454, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647197, Length=163, Percent_Identity=32.5153374233129, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647195, Length=163, Percent_Identity=32.5153374233129, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24647199, Length=156, Percent_Identity=34.6153846153846, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647201, Length=150, Percent_Identity=34, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17737937, Length=131, Percent_Identity=38.1679389312977, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647193, Length=156, Percent_Identity=34.6153846153846, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XDHC_ECO57 (Q8X6C4)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A85942
- PIR:   E91096
- RefSeq:   NP_289438.1
- RefSeq:   NP_311768.1
- ProteinModelPortal:   Q8X6C4
- SMR:   Q8X6C4
- EnsemblBacteria:   EBESCT00000026687
- EnsemblBacteria:   EBESCT00000056098
- GeneID:   916430
- GeneID:   959352
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4207
- KEGG:   ecs:ECs3741
- GeneTree:   EBGT00050000009268
- HOGENOM:   HBG292380
- OMA:   FLHERRD
- ProtClustDB:   PRK09908
- BioCyc:   ECOL83334:ECS3741-MONOMER
- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041
- Gene3D:   G3DSA:1.10.150.120
- Gene3D:   G3DSA:3.10.20.30

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2; SSF47741 2Fe-2S_bind; SSF54292 Ferredoxin

EC number: NA

Molecular weight: Translated: 16950; Mature: 16950

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
10.1 %Cys+Met (Translated Protein)
6.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
10.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHSETITIECTINGMPFQLHAVPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTA
CCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHCCCHHHHCCCCCCCCCEEEEEECCCH
IDSCLYLAAWAEGKEIRTLEGEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAK
HHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHC
PREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK
CCCCCEEHHHHHHHHCCCEEHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNHSETITIECTINGMPFQLHAVPGTPLSELLREQGLLSVKQGCCVGECGACTVLVDGTA
CCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHCCCHHHHCCCCCCCCCEEEEEECCCH
IDSCLYLAAWAEGKEIRTLEGEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAK
HHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHC
PREKPLTITEIRRGLAGNLCRCTGYQMIVNTVLDCEKTK
CCCCCEEHHHHHHHHCCCEEHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796