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The map label for this gene is torZ

Identifier: 209400029

GI number: 209400029

Start: 2462802

End: 2465231

Strand: Reverse

Name: torZ

Synonym: ECH74115_2608

Alternate gene names: 209400029

Gene position: 2465231-2462802 (Counterclockwise)

Preceding gene: 209400901

Following gene: 209396974

Centisome position: 44.24

GC content: 51.6

Gene sequence:

>2430_bases
ATGACATTAACAAGACGTGAATTTATTAAACACAGCGGTATTGCCGCTGGAGCGCTGGTGGTGACATCGGCAGCACCGCT
ACCCGCATGGGCAGAAGAGAAGGGCGGTAAAATCCTCACCGCGGGACGTTGGGGAGCGATGAACGTAGAAGTGAAGGACG
GCAAGATTGTTTCTTCGACAGGCGCGCTGGCGAAAACCATACCGAACTCCTTACAGTCTACGGCGGCGGATCAGGTACAC
ACCACGGCGCGTATTCAGCATCCGATGGTGAGAAAAAGCTATCTCGACAATCCACTGCAACCGGCGAAAGGTCGTGGCGA
AGATACCTATGTACAGGTGAGCTGGGAACAGGCATTAAAACTGATTCATGAGCAACATGAGCGTATTCGTAAAGCTAACG
GACCATCGGCCATTTTTGCCGGATCTTACGGCTGGCGCTCTTCTGGCGTGTTGCATAAAGCGCAAACCTTACTGCAACGT
TATATGAACCTGGCGGGCGGTTATTCCGGGCATAGCGGCGATTATTCAACCGGGGCAGCACAGGTGATCATGCCGCATGT
GGTCGGTTCTGTAGAGGTGTATGAACAGCAGACCTCCTGGCCGCTGATTCTGGAAAACAGCCAGGTTGTGGTGCTGTGGG
GAATGAACCCGCTGAATACCTTAAAAATTGCCTGGAGCAGTACCGATGAGCAAGGGCTGGAATACTTCCATCAGCTGAAA
AAATCTGGCAAACCAGTGATTGCCATTGATCCTATCCGCTCTGAAACCATCGAGTTCTTTGGCTATAATGCCACCTGGAT
CGCGCCGAATATGGGCACCGACGTGGCACTGATGTTAGGGATTGCGCATACCCTGATGACACAAGGCAAACACGATAAAG
TGTTCCTTGAAAAATACACCACCGGGTATCCGCAGTTTGAAGAGTATCTGACAGGTAAGAGCGATAATACTCCGAAGAGC
GCGGCCTGGACGGCGGAAATTACTGGCGTACCGGAAGCGCAGATAGTCAAACTCGCTGAACTGATGGCGGCGAATCGCAC
AATGCTGATGGCAGGCTGGGGAATTCAGCGCCAGCAATATGGTGAACAGAAACACTGGATGCTGGTGACGCTGGCGGCGA
TGTTAGGGCAGATTGGTACACCGGGCGGCGGTTTTGGTTTCTCTTATCATTACTCCAACGGTGGCAACCCGACGCGTGTT
GGCGGCGTGCTGCCGGAAATGTCTGCGGCGATTGCCGGACAGGCCAGCGAGGCCGCTGATGATGGCGGAATGACGGCGAT
TCCTGTTGCCCGTATCGTCGATGCGCTGGAAAATCCTGGCGGCAAATATCAGCATAACGGTAAAGAACAAACGTATCCGA
ATATCAAAATGATCTGGTGGGCGGGTGGCGGTAACTTTACCCATCACCAGGATACTAATCGTCTGATCAAAGCATGGCAG
AAACCGGAGATGATCGTCGTTTCTGAATGCTACTGGACCGCAGCTGCTAAACATGCAGATATCGTATTACCGATCACCAC
ATCGTTTGAGCGCAATGACTTGACGATGACCGGTGATTACAGCAACCAGCATATTGTACCGATGAAGCAGGCTGTCGCTC
CGCAATTTGAAGCGCGAAACGATTTTGACGTGTTTGCCGAACTTGCGGAATTACTGAAACCAGGCGGAAAAGAGATCTAT
ACCGAAGGTAAAGATGAAATGGCGTGGCTGAAATTTTTCTATGATGCCGCTCAGAAAGGTGCCCGTGCGCAACGCGTCAC
TATGCCAATGTTTAATGCCTTCTGGCAGCAAAATAAACTGATCGAAATGCGCCGCAGCGAGAAGAACGAACAGTACGTTC
GTTATGGTGATTTCCGCGCCGATCCGGTGAAAAATGCGCTGGGTACGCCAAGCGGCAAAATTGAGATTTACTCCAAAACG
CTGGAAAAATTTGGCTATAAGGATTGCCCGGCACACCCAACCTGGCTTGCGCCTGATGAGTGGAAAGGTACCGCCGACGA
GAAGCAGTTACAGCTTCTGACCGCACATCCGGCACACCGTTTACACAGTCAGCTTAACTATGCGCAACTGCGTAAAAAAT
ATGCGGTTGCCGATCGTGAACCAATCACTATTCACACCGAAGATGCTGCTCGCTTTGGTATTGCGAATGGCGATCTGGTC
CGTGTCTGGAACAAACGTGGTCAGATTTTGACAGGCGCTGTGGTGACTGACGGGATCAAAAAAGGCGTGGTATGCGTGCA
TGAAGGTGCATGGCCAGATCTGGAAAATGGCTTGTGTAAAAACGGCAGTGCGAACGTGTTAACGGCGGATATCCCCAGCT
CGCAGCTGGCAAATGCCTGTGCCGGTAACTCTGCGCTGGTGTATATCGAAAAATATACGGGTAACGCACCGAAGTTAACG
GCGTTTGATCAGCCAGCTGTTCAGGCATAA

Upstream 100 bases:

>100_bases
CATGAGCGAAAACGAACTGGACATTTTAACGCGGTATTTCCAGTACAACGCCAAAGATATTACCGAGAAACAGTGATCCT
CGTTGATCAGGGAGGAAGTT

Downstream 100 bases:

>100_bases
GACGTGAAAAGCGCCCGGAAACGGGCGCTGAGGTTATGCAAACATAAAGCTGCCTGATGCGCTATGCTTATCAGGCCTAC
ATAGTCCCTGCAATATATTG

Product: trimethylamine N-oxide reductase III, subunit TorZ

Products: NA

Alternate protein names: TMAO reductase 2; Trimethylamine oxidase 2

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMNVEVKDGKIVSSTGALAKTIPNSLQSTAADQVH
TTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQR
YMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
KSGKPVIAIDPIRSETIEFFGYNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKSDNTPKS
AAWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRV
GGVLPEMSAAIAGQASEAADDGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFAELAELLKPGGKEIY
TEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKT
LEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAQLRKKYAVADREPITIHTEDAARFGIANGDLV
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANACAGNSALVYIEKYTGNAPKLT
AFDQPAVQA

Sequences:

>Translated_809_residues
MTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMNVEVKDGKIVSSTGALAKTIPNSLQSTAADQVH
TTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQR
YMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
KSGKPVIAIDPIRSETIEFFGYNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKSDNTPKS
AAWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRV
GGVLPEMSAAIAGQASEAADDGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFAELAELLKPGGKEIY
TEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKT
LEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAQLRKKYAVADREPITIHTEDAARFGIANGDLV
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANACAGNSALVYIEKYTGNAPKLT
AFDQPAVQA
>Mature_808_residues
TLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMNVEVKDGKIVSSTGALAKTIPNSLQSTAADQVHT
TARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRY
MNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLKK
SGKPVIAIDPIRSETIEFFGYNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKSDNTPKSA
AWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVG
GVLPEMSAAIAGQASEAADDGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQK
PEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFAELAELLKPGGKEIYT
EGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTL
EKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAQLRKKYAVADREPITIHTEDAARFGIANGDLVR
VWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANACAGNSALVYIEKYTGNAPKLTA
FDQPAVQA

Specific function: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family

Homologues:

Organism=Escherichia coli, GI87081994, Length=809, Percent_Identity=98.7639060568603, Blast_Score=1664, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=773, Percent_Identity=63.777490297542, Blast_Score=1061, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=786, Percent_Identity=45.5470737913486, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=31.25, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI1787870, Length=848, Percent_Identity=29.0094339622642, Blast_Score=270, Evalue=3e-73,
Organism=Escherichia coli, GI171474008, Length=840, Percent_Identity=28.5714285714286, Blast_Score=238, Evalue=1e-63,
Organism=Escherichia coli, GI3868721, Length=719, Percent_Identity=22.9485396383866, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TORZ_ECO57 (P58362)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85800
- PIR:   F90951
- RefSeq:   NP_288309.1
- RefSeq:   NP_310609.2
- ProteinModelPortal:   P58362
- SMR:   P58362
- EnsemblBacteria:   EBESCT00000029070
- EnsemblBacteria:   EBESCT00000059176
- GeneID:   914087
- GeneID:   961845
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z2925
- KEGG:   ecs:ECs2582
- GeneTree:   EBGT00050000008999
- HOGENOM:   HBG304064
- OMA:   MIREEVM
- ProtClustDB:   CLSK874609
- BioCyc:   ECOL83334:ECS2582-MONOMER
- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311
- Gene3D:   G3DSA:2.40.40.20
- TIGRFAMs:   TIGR00509
- TIGRFAMs:   TIGR01409

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding; SSF50692 Asp_decarb_fold

EC number: =1.7.2.3

Molecular weight: Translated: 88980; Mature: 88849

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1; PS00490 MOLYBDOPTERIN_PROK_2; PS00932 MOLYBDOPTERIN_PROK_3; PS51318 TAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMNVEVKDGKIVSST
CCCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCEEEEECCCCEEEEEECCCEEEECC
GALAKTIPNSLQSTAADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHH
LIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRYMNLAGGYSGHSGDYSTGAA
HHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
QVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
HHHHHHHHCCEEEEECCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHH
KSGKPVIAIDPIRSETIEFFGYNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYT
HCCCCEEEECCCCCCEEHEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHC
TGYPQFEEYLTGKSDNTPKSAAWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQY
CCCCCHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHH
GEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVGGVLPEMSAAIAGQASEAAD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCC
DGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHC
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARN
CCCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCCEECCHHHHHCCCCCCCC
DFDVFAELAELLKPGGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKL
CHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHH
IEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTLEKFGYKDCPAHPTWLAPDE
HHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCC
WKGTADEKQLQLLTAHPAHRLHSQLNYAQLRKKYAVADREPITIHTEDAARFGIANGDLV
CCCCCCHHHEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEE
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANAC
EEECCCCCEEEEHHHHCCHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
AGNSALVYIEKYTGNAPKLTAFDQPAVQA
CCCCEEEEEEECCCCCCCEEECCCCCCCC
>Mature Secondary Structure 
TLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMNVEVKDGKIVSST
CCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCEEEEECCCCEEEEEECCCEEEECC
GALAKTIPNSLQSTAADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHH
LIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRYMNLAGGYSGHSGDYSTGAA
HHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
QVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
HHHHHHHHCCEEEEECCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHH
KSGKPVIAIDPIRSETIEFFGYNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYT
HCCCCEEEECCCCCCEEHEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHC
TGYPQFEEYLTGKSDNTPKSAAWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQY
CCCCCHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHH
GEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVGGVLPEMSAAIAGQASEAAD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCC
DGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHC
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARN
CCCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCCEECCHHHHHCCCCCCCC
DFDVFAELAELLKPGGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKL
CHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHH
IEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTLEKFGYKDCPAHPTWLAPDE
HHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCC
WKGTADEKQLQLLTAHPAHRLHSQLNYAQLRKKYAVADREPITIHTEDAARFGIANGDLV
CCCCCCHHHEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEE
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANAC
EEECCCCCEEEEHHHHCCHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
AGNSALVYIEKYTGNAPKLTAFDQPAVQA
CCCCEEEEEEECCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796