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The map label for this gene is torY

Identifier: 209400901

GI number: 209400901

Start: 2465256

End: 2466356

Strand: Reverse

Name: torY

Synonym: ECH74115_2609

Alternate gene names: 209400901

Gene position: 2466356-2465256 (Counterclockwise)

Preceding gene: 209396910

Following gene: 209400029

Centisome position: 44.26

GC content: 47.68

Gene sequence:

>1101_bases
ATGCGAGGGAAAAAACGCATTGGGTTATTGTTTTTGCTGATAGCGGTTGTGGTTGGTGGTGGCGGGTTCTTGATGGCGCA
AAAAGCCTTACATAAAACGTCGGATACAGCATTTTGCCTTTCCTGCCACTCGATGAGTAAACCTTTTGAGGAATATCAGG
GAACTGTCCACTTTTCGAACCAGAAAGGGATACGTGCGGAATGTGCCGATTGCCATATTCCAAAGTCAGGGATGGATTAT
TTATTCGCTAAATTAAAAGCATCTAAAGATATTTATCATGAATTTGTTAGCGGCAAAATAGACAGTGACGATAAGTTCGA
AGCTCATCGCCAGGAAATGGCCGAAACAGTATGGAAAGAATTAAAAGCAACTGACTCTGCAACGTGCCGTAGTTGCCATT
CTTTTGATGCCATGGATATTGCCTCGCAAAGTGAATCTGCGCAGAAAATGCATAACAAAGCACAAAAGGGCGGCGAAACC
TGTATCGATTGTCATAAAGGCATTGCCCATTTTCCGCCAGAAATAAAAATGGATGACAACGCGGCGCATGAGCTGGAAAG
TCAGGCCGCTACTTCAGTGACTAATGGCGCACATATTTATCCTTTCAAAACTTCTCGCATAGGCGAGCTGGCTACCGTGA
ATCCTGGTACCGATCTCACCGTCGTTGATGCCAGTGGCAAACAGCCGATCGTTCTGTTGCAGGGTTATCAAATGCAGGGC
AGTGAAAACACGCTCTACCTGGCGGCAGGTCAACGGCTGGCGCTAGCCACATTAAGTGAAGAAGGTATCAAGGCGCTCAC
GGTAAACGGGGAATGGCAGGCTGACGAATACGGCAATCAATGGCGTCAGGCGTCTTTACAGGGTGCGCTTACCGATCCCG
CATTAGCGGACCGTAAACTGCTATGGCAATACGCTGAAAAACTTGACGATACCTATTGCGCTGGTTGTCATGCCCCTATT
GCCGCCGACCATTACACCGTCAATGCGTGGCCGTCCATTGCCAAAGGAATGGGGGCACGAACCAGCATGAGCGAAAACGA
ACTGGACATTTTAACGCGGTATTTCCAGTACAACGCCAAAGATATTACCGAGAAACAGTGA

Upstream 100 bases:

>100_bases
TATTTCAGGCAGTGTTGTGCCGAATTAAGCAAGTAGTCAATTCGTTGTGTATTTATTTATACAATGATTTCGGTGTTCTG
GAGTTTAATTAGAGGAATCT

Downstream 100 bases:

>100_bases
TCCTCGTTGATCAGGGAGGAAGTTATGACATTAACAAGACGTGAATTTATTAAACACAGCGGTATTGCCGCTGGAGCGCT
GGTGGTGACATCGGCAGCAC

Product: trimethylamine N-oxide reductase III, c-type cytochrome subunit TorY

Products: H2O; trimethylamine; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MRGKKRIGLLFLLIAVVVGGGGFLMAQKALHKTSDTAFCLSCHSMSKPFEEYQGTVHFSNQKGIRAECADCHIPKSGMDY
LFAKLKASKDIYHEFVSGKIDSDDKFEAHRQEMAETVWKELKATDSATCRSCHSFDAMDIASQSESAQKMHNKAQKGGET
CIDCHKGIAHFPPEIKMDDNAAHELESQAATSVTNGAHIYPFKTSRIGELATVNPGTDLTVVDASGKQPIVLLQGYQMQG
SENTLYLAAGQRLALATLSEEGIKALTVNGEWQADEYGNQWRQASLQGALTDPALADRKLLWQYAEKLDDTYCAGCHAPI
AADHYTVNAWPSIAKGMGARTSMSENELDILTRYFQYNAKDITEKQ

Sequences:

>Translated_366_residues
MRGKKRIGLLFLLIAVVVGGGGFLMAQKALHKTSDTAFCLSCHSMSKPFEEYQGTVHFSNQKGIRAECADCHIPKSGMDY
LFAKLKASKDIYHEFVSGKIDSDDKFEAHRQEMAETVWKELKATDSATCRSCHSFDAMDIASQSESAQKMHNKAQKGGET
CIDCHKGIAHFPPEIKMDDNAAHELESQAATSVTNGAHIYPFKTSRIGELATVNPGTDLTVVDASGKQPIVLLQGYQMQG
SENTLYLAAGQRLALATLSEEGIKALTVNGEWQADEYGNQWRQASLQGALTDPALADRKLLWQYAEKLDDTYCAGCHAPI
AADHYTVNAWPSIAKGMGARTSMSENELDILTRYFQYNAKDITEKQ
>Mature_366_residues
MRGKKRIGLLFLLIAVVVGGGGFLMAQKALHKTSDTAFCLSCHSMSKPFEEYQGTVHFSNQKGIRAECADCHIPKSGMDY
LFAKLKASKDIYHEFVSGKIDSDDKFEAHRQEMAETVWKELKATDSATCRSCHSFDAMDIASQSESAQKMHNKAQKGGET
CIDCHKGIAHFPPEIKMDDNAAHELESQAATSVTNGAHIYPFKTSRIGELATVNPGTDLTVVDASGKQPIVLLQGYQMQG
SENTLYLAAGQRLALATLSEEGIKALTVNGEWQADEYGNQWRQASLQGALTDPALADRKLLWQYAEKLDDTYCAGCHAPI
AADHYTVNAWPSIAKGMGARTSMSENELDILTRYFQYNAKDITEKQ

Specific function: Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme

COG id: COG3005

COG function: function code C; Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TorC/TorY family

Homologues:

Organism=Escherichia coli, GI1788181, Length=366, Percent_Identity=98.0874316939891, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1787230, Length=374, Percent_Identity=33.4224598930481, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788530, Length=180, Percent_Identity=43.8888888888889, Blast_Score=161, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TORY_ECO57 (P58361)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C85800
- PIR:   G90951
- RefSeq:   NP_288310.1
- RefSeq:   NP_310610.1
- ProteinModelPortal:   P58361
- EnsemblBacteria:   EBESCT00000024800
- EnsemblBacteria:   EBESCT00000058329
- GeneID:   912611
- GeneID:   961846
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z2926
- KEGG:   ecs:ECs2583
- GeneTree:   EBGT00050000010586
- HOGENOM:   HBG303867
- OMA:   WIGVVNS
- ProtClustDB:   CLSK874610
- BioCyc:   ECOL83334:ECS2583-MONOMER
- GO:   GO:0006810
- InterPro:   IPR009154
- InterPro:   IPR011031
- InterPro:   IPR005126
- PIRSF:   PIRSF000014

Pfam domain/function: PF03264 Cytochrom_NNT

EC number: NA

Molecular weight: Translated: 40258; Mature: 40258

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS51008 MULTIHEME_CYTC

Important sites: BINDING 39-39 BINDING 42-42 BINDING 68-68 BINDING 71-71 BINDING 129-129 BINDING 132-132 BINDING 161-161 BINDING 164-164 BINDING 313-313 BINDING 316-316

Signals:

None

Transmembrane regions:

HASH(0x20cce4f8)-;

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKKRIGLLFLLIAVVVGGGGFLMAQKALHKTSDTAFCLSCHSMSKPFEEYQGTVHFSN
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEHHHHCCCHHHHCCEEEECC
QKGIRAECADCHIPKSGMDYLFAKLKASKDIYHEFVSGKIDSDDKFEAHRQEMAETVWKE
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LKATDSATCRSCHSFDAMDIASQSESAQKMHNKAQKGGETCIDCHKGIAHFPPEIKMDDN
HHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCCCEECCC
AAHELESQAATSVTNGAHIYPFKTSRIGELATVNPGTDLTVVDASGKQPIVLLQGYQMQG
HHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCEEEEECCCCCCEEEEECEEECC
SENTLYLAAGQRLALATLSEEGIKALTVNGEWQADEYGNQWRQASLQGALTDPALADRKL
CCCEEEEECCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
LWQYAEKLDDTYCAGCHAPIAADHYTVNAWPSIAKGMGARTSMSENELDILTRYFQYNAK
HHHHHHHHCCCHHCCCCCCCCCCCEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
DITEKQ
CCCCCH
>Mature Secondary Structure
MRGKKRIGLLFLLIAVVVGGGGFLMAQKALHKTSDTAFCLSCHSMSKPFEEYQGTVHFSN
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEHHHHCCCHHHHCCEEEECC
QKGIRAECADCHIPKSGMDYLFAKLKASKDIYHEFVSGKIDSDDKFEAHRQEMAETVWKE
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LKATDSATCRSCHSFDAMDIASQSESAQKMHNKAQKGGETCIDCHKGIAHFPPEIKMDDN
HHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCCCEECCC
AAHELESQAATSVTNGAHIYPFKTSRIGELATVNPGTDLTVVDASGKQPIVLLQGYQMQG
HHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCEEEEECCCCCCEEEEECEEECC
SENTLYLAAGQRLALATLSEEGIKALTVNGEWQADEYGNQWRQASLQGALTDPALADRKL
CCCEEEEECCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
LWQYAEKLDDTYCAGCHAPIAADHYTVNAWPSIAKGMGARTSMSENELDILTRYFQYNAK
HHHHHHHHCCCHHCCCCCCCCCCCEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
DITEKQ
CCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: trimethylamine-N-oxide; NADH [C]

Specific reaction: trimethylamine-N-oxide + NADH = H2O + trimethylamine + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796