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The map label for this gene is lsrD

Identifier: 209399642

GI number: 209399642

Start: 2042570

End: 2043562

Strand: Direct

Name: lsrD

Synonym: ECH74115_2128

Alternate gene names: 209399642

Gene position: 2042570-2043562 (Clockwise)

Preceding gene: 209398891

Following gene: 209400955

Centisome position: 36.66

GC content: 53.78

Gene sequence:

>993_bases
ATGCGTATTCGCTACGGTTGGGAACTGGCTCTTGCCGCACTGCTTGTTATTGAGATTGTCTCATTTGGTGCAATTAACCC
GCGGATGTTAGATCTCAATATGTTGCTGTTCAGCACCAGTGACTTTATCTGCATTGGCATTGTCGCCCTACCGCTGACGA
TGGTGATTGTCAGTGGCGGGATCGATATTTCGTTTGGTTCGACCATCGGCCTCTGCGCCATTGCATTGGGCGTACTGTTT
CAAAGTGGTGTGCCGATGCCGCTGGCGATTCTCCTGACCTTACTGCTCGGCGCATTGTGCGGGCTGATCAACGCCGGATT
AATTATCTATACCAAAGTTAACCCGCTGGTGATTACGCTTGGCACGCTGTATCTGTTTGCCGGAAGCGCCCTGCTGCTTT
CCGGGATGGCCGGGGCGACGGGGTACGAAGGTATTGGTGGATTCCCGATGGCGTTTACAGATTTCGCTAACCTGGATGTG
TTGGGGCTCCCCGTTCCGCTGATTATCTTCCTGATATGTCTCCTCGTTTTCTGGCTCTGGCTGCATAAAACCCATGCCGG
ACGTAACGTGTTTTTGATTGGGCAAAGCCCGCGCGTGGCGCTTTATAGCGCGATTCCAGTTAACCGTACCTTATGTGCGC
TCTATGCCATGACGGGGCTGGCGTCTGCGGTCGCCGCTGTGCTGCTGGTGTCGTATTTTGGTTCAGCACGTTCCGATCTC
GGTGCGTCGTTTCTGATGCCCGCCATCACCGCCGTGGTGCTTGGCGGTGCCAATATTTATGGTGGTTCCGGTGCCATTAT
CGGCACCGCCATTGCGGTTTTATTAGTGGGATATTTGCAACAAGGTTTGCAAATGGCAGGAGTGCCAAATCAGGTGTCCA
GCGCCCTTTCCGGTGCGCTACTTATCGTCGTTGTCGTAGGTCGTTCCGTTAGCCTGCATCGCCAGCAAATTAAAGAGTGG
CTGGCGCGTCGGGCCAATAACCCATTGCCATAA

Upstream 100 bases:

>100_bases
CGCTGGAACTTAATCTGCGGCGGCAAAAATATGCCCGCTTTATGACGCCACCGCCATCCGTTAAACCCGCTTCGTCAGGT
AAAAAACGGGAGGCTGCATA

Downstream 100 bases:

>100_bases
AGGATATCTTCATGACACTTCATCGCTTTAAGAAAATCGCCTTACTTAGCGCTCTTGGCATTGCCGCAATCTCTATGAAT
GTGCAGGCCGCAGAGCGTAT

Product: autoinducer-2 ABC transporter, permease protein LsrD

Products: NA

Alternate protein names: AI-2 import system permease protein lsrD

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRIRYGWELALAALLVIEIVSFGAINPRMLDLNMLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIALGVLF
QSGVPMPLAILLTLLLGALCGLINAGLIIYTKVNPLVITLGTLYLFAGSALLLSGMAGATGYEGIGGFPMAFTDFANLDV
LGLPVPLIIFLICLLVFWLWLHKTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAVAAVLLVSYFGSARSDL
GASFLMPAITAVVLGGANIYGGSGAIIGTAIAVLLVGYLQQGLQMAGVPNQVSSALSGALLIVVVVGRSVSLHRQQIKEW
LARRANNPLP

Sequences:

>Translated_330_residues
MRIRYGWELALAALLVIEIVSFGAINPRMLDLNMLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIALGVLF
QSGVPMPLAILLTLLLGALCGLINAGLIIYTKVNPLVITLGTLYLFAGSALLLSGMAGATGYEGIGGFPMAFTDFANLDV
LGLPVPLIIFLICLLVFWLWLHKTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAVAAVLLVSYFGSARSDL
GASFLMPAITAVVLGGANIYGGSGAIIGTAIAVLLVGYLQQGLQMAGVPNQVSSALSGALLIVVVVGRSVSLHRQQIKEW
LARRANNPLP
>Mature_330_residues
MRIRYGWELALAALLVIEIVSFGAINPRMLDLNMLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIALGVLF
QSGVPMPLAILLTLLLGALCGLINAGLIIYTKVNPLVITLGTLYLFAGSALLLSGMAGATGYEGIGGFPMAFTDFANLDV
LGLPVPLIIFLICLLVFWLWLHKTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAVAAVLLVSYFGSARSDL
GASFLMPAITAVVLGGANIYGGSGAIIGTAIAVLLVGYLQQGLQMAGVPNQVSSALSGALLIVVVVGRSVSLHRQQIKEW
LARRANNPLP

Specific function: Part of the ABC transporter complex lsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane

COG id: COG1172

COG function: function code G; Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. AraH/rbsC subfamily

Homologues:

Organism=Escherichia coli, GI1787794, Length=330, Percent_Identity=99.3939393939394, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1790524, Length=307, Percent_Identity=28.6644951140065, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790191, Length=289, Percent_Identity=30.1038062283737, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693152, Length=274, Percent_Identity=28.8321167883212, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788896, Length=318, Percent_Identity=28.9308176100629, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788471, Length=221, Percent_Identity=33.0316742081448, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787793, Length=311, Percent_Identity=31.1897106109325, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI145693214, Length=274, Percent_Identity=27.007299270073, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082395, Length=308, Percent_Identity=26.2987012987013, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789992, Length=133, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSRD_ECO57 (Q8X504)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B90894
- PIR:   G85723
- RefSeq:   NP_287639.1
- RefSeq:   NP_310149.1
- EnsemblBacteria:   EBESCT00000027413
- EnsemblBacteria:   EBESCT00000057457
- GeneID:   917327
- GeneID:   960651
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z2190
- KEGG:   ecs:ECs2122
- GeneTree:   EBGT00050000010180
- HOGENOM:   HBG663180
- OMA:   LNWESAL
- ProtClustDB:   PRK15038
- BioCyc:   ECOL83334:ECS2122-MONOMER
- InterPro:   IPR001851

Pfam domain/function: PF02653 BPD_transp_2

EC number: NA

Molecular weight: Translated: 34457; Mature: 34457

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20babd68)-; HASH(0x20173c1c)-; HASH(0x1f69bf9c)-; HASH(0x20c40b80)-; HASH(0x20134b28)-; HASH(0x20b23fa8)-; HASH(0x2072a0fc)-; HASH(0x208e0c94)-; HASH(0x2019c78c)-; HASH(0x20c629ac)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRYGWELALAALLVIEIVSFGAINPRMLDLNMLLFSTSDFICIGIVALPLTMVIVSGG
CCEECHHHHHHHHHHHHHHHHCCCCCCEEEEHEEHECCCCCHHHHHHHHHHHHHHHHCCC
IDISFGSTIGLCAIALGVLFQSGVPMPLAILLTLLLGALCGLINAGLIIYTKVNPLVITL
CEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHH
GTLYLFAGSALLLSGMAGATGYEGIGGFPMAFTDFANLDVLGLPVPLIIFLICLLVFWLW
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEECCCHHHHHHHHHHHHHHHH
LHKTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAVAAVLLVSYFGSARSDL
HHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
GASFLMPAITAVVLGGANIYGGSGAIIGTAIAVLLVGYLQQGLQMAGVPNQVSSALSGAL
CHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LIVVVVGRSVSLHRQQIKEWLARRANNPLP
HEEHHHCCCHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MRIRYGWELALAALLVIEIVSFGAINPRMLDLNMLLFSTSDFICIGIVALPLTMVIVSGG
CCEECHHHHHHHHHHHHHHHHCCCCCCEEEEHEEHECCCCCHHHHHHHHHHHHHHHHCCC
IDISFGSTIGLCAIALGVLFQSGVPMPLAILLTLLLGALCGLINAGLIIYTKVNPLVITL
CEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHH
GTLYLFAGSALLLSGMAGATGYEGIGGFPMAFTDFANLDVLGLPVPLIIFLICLLVFWLW
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEECCCHHHHHHHHHHHHHHHH
LHKTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAVAAVLLVSYFGSARSDL
HHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
GASFLMPAITAVVLGGANIYGGSGAIIGTAIAVLLVGYLQQGLQMAGVPNQVSSALSGAL
CHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LIVVVVGRSVSLHRQQIKEWLARRANNPLP
HEEHHHCCCHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796