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The map label for this gene is lsrC

Identifier: 209398891

GI number: 209398891

Start: 2041542

End: 2042570

Strand: Direct

Name: lsrC

Synonym: ECH74115_2127

Alternate gene names: 209398891

Gene position: 2041542-2042570 (Clockwise)

Preceding gene: 209395735

Following gene: 209399642

Centisome position: 36.64

GC content: 53.84

Gene sequence:

>1029_bases
ATGCTGAAGTTTATTCAGAACAACCGTGAAATCACGGCACTGCTGGCGGTGCTGCTGCTGTTTGTATTACCCGGTTTTCT
CGACCGCCAGTATTTAAGTGTGCAAACGCTGACCATGGTTTATAGCAGCGCGCAAATCCTGATCCTGCTGGCAATGGGCG
CGACGCTGGTAATGCTTACGCGCAATATTGATGTTTCAGTGGGTTCGATTACCGGAATGTGCGCGGTGCTGTTGGGGATG
TTACTGAACGCAGGATATTCACTACCTGTTGCCTGTGTCGCGACTTTACTGCTTGGTTTGCTCGCGGGATTTTTCAACGG
TGTCCTGGTCGCGTGGCTAAAGATCCCTGCCATTGTTGCCACCCTTGGCACGTTAGGGTTGTACAGAGGCATCATGTTGC
TGTGGACTGGCGGTAAATGGATTGAAGGGTTACCCGCCGAACTGAAACAGCTCTCCGCCCCGCTGCTGCTTGGCGTTTCA
GCAATTGGTTGGTTAACGATAATTCTGGTGGCATTTATGGCCTGGCTGCTGGCGAAGACAGCGTTTGGACGCAGTTTTTA
TGCCACGGGCGATAATTTACAGGGCGCTCGTCAACTGGGCGTTCGTACGGAAGCCATTCGCATTGTGGCATTTTCGTTGA
ACGGCTGCATGGCGGCACTGGCGGGAATTGTGTTTGCTTCGCAGATTGGTTTTATCCCCAACCAGACCGGTACCGGGCTG
GAGATGAAAGCAATTGCAGCCTGCGTGCTGGGCGGCATTAGTTTGCTCGGCGGTTCCGGTGCGATCATCGGTGCGGTACT
CGGCGCATGGTTCCTGACGCAGATCGATAGCGTACTGGTGCTGTTGCGCATTCCGGCATGGTGGAATGATTTTATCGCGG
GTCTGGTTCTGCTGGCGGTGCTGGTGTTTGATGGACGCCTGCGTTGTGCGCTGGAACTTAATCTGCGGCGGCAAAAATAT
GCCCGCTTTATGACGCCACCGCCATCCGTTAAACCCGCTTCGTCAGGTAAAAAACGGGAGGCTGCATAA

Upstream 100 bases:

>100_bases
ATCAGGGCGAAATTACCCACTCTGCACTGACCGGGCGCGATATTAATGTCGAGACTATTATGCGCGTTGCCTTCGGCGAT
AGTCAGCGTCAGGAGGCGGC

Downstream 100 bases:

>100_bases
TGCGTATTCGCTACGGTTGGGAACTGGCTCTTGCCGCACTGCTTGTTATTGAGATTGTCTCATTTGGTGCAATTAACCCG
CGGATGTTAGATCTCAATAT

Product: autoinducer-2 ABC transporter, permease protein LsrC

Products: NA

Alternate protein names: AI-2 import system permease protein lsrC

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLKFIQNNREITALLAVLLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGM
LLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVS
AIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGL
EMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALELNLRRQKY
ARFMTPPPSVKPASSGKKREAA

Sequences:

>Translated_342_residues
MLKFIQNNREITALLAVLLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGM
LLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVS
AIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGL
EMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALELNLRRQKY
ARFMTPPPSVKPASSGKKREAA
>Mature_342_residues
MLKFIQNNREITALLAVLLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGM
LLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVS
AIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGL
EMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALELNLRRQKY
ARFMTPPPSVKPASSGKKREAA

Specific function: Part of the ABC transporter complex lsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane

COG id: COG1172

COG function: function code G; Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. AraH/rbsC subfamily

Homologues:

Organism=Escherichia coli, GI1787793, Length=342, Percent_Identity=99.4152046783626, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI1789992, Length=362, Percent_Identity=30.939226519337, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790191, Length=305, Percent_Identity=32.1311475409836, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI145693152, Length=256, Percent_Identity=35.15625, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788896, Length=303, Percent_Identity=31.023102310231, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790524, Length=277, Percent_Identity=27.0758122743682, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693214, Length=256, Percent_Identity=35.9375, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082395, Length=288, Percent_Identity=30.9027777777778, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787794, Length=303, Percent_Identity=31.023102310231, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788471, Length=313, Percent_Identity=30.3514376996805, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSRC_ECO57 (Q8XAY8)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A90894
- PIR:   H85723
- RefSeq:   NP_287640.1
- RefSeq:   NP_310148.1
- EnsemblBacteria:   EBESCT00000026250
- EnsemblBacteria:   EBESCT00000055923
- GeneID:   917325
- GeneID:   960652
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z2191
- KEGG:   ecs:ECs2121
- GeneTree:   EBGT00050000010181
- HOGENOM:   HBG663180
- OMA:   GSGLEMK
- ProtClustDB:   PRK15432
- BioCyc:   ECOL83334:ECS2121-MONOMER
- InterPro:   IPR001851

Pfam domain/function: PF02653 BPD_transp_2

EC number: NA

Molecular weight: Translated: 36366; Mature: 36366

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20a22f6c)-; HASH(0x20b29944)-; HASH(0x20c5cdd0)-; HASH(0x20c96168)-; HASH(0x20a5509c)-; HASH(0x20b3c408)-; HASH(0x2078a558)-; HASH(0x203d20a4)-; HASH(0x20c5c138)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKFIQNNREITALLAVLLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLT
CCCCCCCCCHHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVSAIGWLTIILVAFMAWLLAKT
HHHHHHHHHHHHEEECCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGL
HHCCEEECCCCCCCHHHHHCCHHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVFDGRLRCALELNLRRQKYARFMTPPPSVKPASSGKKREAA
HHHCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MLKFIQNNREITALLAVLLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLT
CCCCCCCCCHHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVSAIGWLTIILVAFMAWLLAKT
HHHHHHHHHHHHEEECCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGL
HHCCEEECCCCCCCHHHHHCCHHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVFDGRLRCALELNLRRQKYARFMTPPPSVKPASSGKKREAA
HHHCCCEEEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796