Click here to switch to the map view.

The map label for this gene is xdhA [H]

Identifier: 209396943

GI number: 209396943

Start: 3843034

End: 3845331

Strand: Direct

Name: xdhA [H]

Synonym: ECH74115_4156

Alternate gene names: 209396943

Gene position: 3843034-3845331 (Clockwise)

Preceding gene: 209396812

Following gene: 209397706

Centisome position: 68.97

GC content: 53.0

Gene sequence:

>2298_bases
ATGGAAGCGCGGGAAGCAACCGCTACGGGTGAATCATGCATGCGCGTTGATGCCATTGCTAAGGTCACCGGGCGGGCACG
ATATACTGACGATTATGTTATGGCGGGCATGTGTTATGCGAAATATGTACGTAGCCCTATCGCACATGGTTATGCCGTAA
GTATTAATGATGAACAAGCCAGAAGTTTACCAGGCGTACTGGCGATTTTTACCTGGGAAGATGTGCCTGATATCCCATTC
GCTACAGCTGGGCATGCATGGACACTTGACGAAAACAAGCGCGATACCGCCGATCGCGCACTGCTAACTCGCCATGTTCG
TCATCATGGTGACGCCGTTGCCATCGTCGTGGCCCGCGATGAACTCACGGCAGAAAAAGCGGCGCAATTGGTCAGCATTG
AGTGGGAAGAATTACCCGTTATCACCACGCCAGAAGCGGCGCTGGCAGAGGACGCTGCACCAATCCATAACGGCGGCAAT
TTACTGAAACAAAGCACGATGTCGACGGGCAATGTCCAACAAACAATCGATGCCGCCGACTACCAGGTACAGGGGCACTA
TCAGACCCCCGTTATTCAACATTGTCACATGGAAAGCGTAACATCGCTGGCGTGGATGGAGGATGACTCGCGAATTACCA
TCGTTTCCAGCACCCAGATCCCGCACATTGTTCGCCGCGTGGTTGGTCAGGCGCTGGATATTCCCTGGTCATGCGTACGA
GTCATCAAACCATTTGTCGGTGGCGGTTTTGGTAATAAACAGGATGTACTGGAAGAGCCAATGGCGGCATTCCTGACCAG
CAAGCTTGGCGGCATTCCGGTGAAAGTTTCCCTTAGCCGTGAAGAGTGTTTCCTCGCAACCCGTACCCGCCACGCTTTTA
CTATTGACGGGCAAATGGGCGTGAACCGCGACGGAACATTGAAAGGTTATAGTCTGGATGTTCTGTCTAACACCGGCGCT
TATGTATCTCACGGGCACTCCATCGCTTCTGCAGGGGGAAATAAAGTCGCTTACCTTTATCCTCGTTGTGCCTACGCTTA
CAGTTCAAAGACCTGCTATACCAACCTCCCCTCGGCTGGTGCGATGCGTGGTTATGGCGCGCCACAAGTCGTATTTGCCG
TTGAGTCTATGCTTGATGACGCCGCGACAGCGTTAGGTATTGATCCTGTTGAAATTCGTTTACGCAACGCCTCACGCGAA
GGAGATGCTAATCCGCTCACGGGCAAACGTATTTACAGCGCAGGGTTGCCGGAGTGTCTTGAAAAAGGCCGGAAAATCTT
TGAATGGGAAAAACGCCGTGCAGAGTGCCAGAACCAGCAAGGCAATTTACGCCGCGGCGTTGGCGTCGCCTGTTTTAGCT
ACACCTCTAACACCTGGCCTGTCGGCGTAGAAATAGCAGGCGCGCGCCTTCTGATGAATCAGGATGGAACCATCAACGTG
CAAAGCGGCGCGACGGAAATCGGTCAGGGTGCCGACACCGTCTTCTCGCAAATGGTGGCAGAAACCGTGGGGGTTCCGGT
CAGCGACGTTCGCGTTATTTCAACACAAGATACCGACGTTACGCCGTTCGATCCCGGCGCATTTGCCTCACGCCAGAGCT
ATGTTGCCGCGCCTGCGCTGCGCAGTGCGGCACTGTTATTAAAAGAGAAAATCATCGCTCACGCCGCAGTCATGCTACAT
CAGTCAGCGATGAATCTGACCCTGATAAAAGGCCATATCGTGCTGGTTGAACGACCGGAAGAGCCGTTAATGTCGTTAAA
AGATTTGGCGATGGACGCTTTCTACCACCCTGAACGCGGCGGGCAGCTCTCTGCTGAAAGCTCCATCAAAACCACCACTA
ACCCACCGGCGTTCGGCTGTACCTTTGTTGATCTGACGGTCGATATTGCGCTGTGCAAAGTCACCATCAACCGCATCCTC
AACGTTCATGATTCGGGCCATATTCTTAATCCGCTACTGGCAGAAGGTCAGGTACACGGCGGAATGGGAATGGGCATTGG
CTGGGCGCTATTTGAAGAGATGATCATCGATGCGAAAAGCGGCGTGGTCCGTAACCCCAATCTGCTGGATTACAAAATGC
CGACCATGCCGGATCTGCCACAACTGGAAAGCGCGTTCGTCGAAATCAATGAGCCGCAATCCGCATACGGACATAAGTCA
CTGGGTGAGCCACCAATAATTCCTGTTGCCGCTGCTATTCGTAACGCGGTGAAGATGGCTACCGGTGTTGCAATCAATAC
ACTGCCGCTGACGCCAAAACGGTTATATGAAGAGTTCCATCTGGCAGGATTGATTTGA

Upstream 100 bases:

>100_bases
CTTCCTCCCTTAACGCTTATCGCCGTTTCTGGCGTAAATCTTGCCTGCTTAGACTAAATCTTTGCCATAAGAACCAAATG
TTCAAATCGAGGGGATTTCT

Downstream 100 bases:

>100_bases
GGATAACATCATGTTTGATTTTGCTTCTTACCATCGCGCAGCAACCCTTGCCGATGCCATCAACCTGCTGGCTGACAACC
CGCAGGCCAAACTGCTCGCC

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWEELPVITTPEAALAEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGA
YVSHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNASRE
GDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Sequences:

>Translated_765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWEELPVITTPEAALAEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGA
YVSHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNASRE
GDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
>Mature_765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWEELPVITTPEAALAEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGA
YVSHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNASRE
GDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=793, Percent_Identity=26.3556116015132, Blast_Score=174, Evalue=4e-43,
Organism=Homo sapiens, GI91823271, Length=764, Percent_Identity=24.869109947644, Blast_Score=169, Evalue=1e-41,
Organism=Escherichia coli, GI1789230, Length=752, Percent_Identity=99.6010638297872, Blast_Score=1556, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=798, Percent_Identity=29.9498746867168, Blast_Score=310, Evalue=3e-85,
Organism=Escherichia coli, GI1786478, Length=763, Percent_Identity=28.9646133682831, Blast_Score=221, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17540638, Length=779, Percent_Identity=26.7008985879332, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17539860, Length=729, Percent_Identity=23.3196159122085, Blast_Score=158, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32566215, Length=734, Percent_Identity=23.433242506812, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=26.2449528936743, Blast_Score=193, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24647193, Length=769, Percent_Identity=24.1872561768531, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647199, Length=749, Percent_Identity=23.3644859813084, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647201, Length=754, Percent_Identity=23.6074270557029, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24647195, Length=713, Percent_Identity=21.4586255259467, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24647197, Length=709, Percent_Identity=21.5796897038082, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82704; Mature: 82704

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHH
RSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARD
HCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECC
ELTAEKAAQLVSIEWEELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAAD
HHCHHHHHHEEEEEHHHCCEEECCCHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCC
YQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
EEEECCCCCHHHHHHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHH
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCC
VNRDGTLKGYSLDVLSNTGAYVSHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAG
CCCCCCCCCEEEEEECCCCCHHCCCCCHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCC
AMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNASREGDANPLTGKRIYSAGLPECL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCHHHH
EKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
HHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEE
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPAL
CCCCCHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
GQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHG
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
GMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCC
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
CCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHH
RSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARD
HCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECC
ELTAEKAAQLVSIEWEELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAAD
HHCHHHHHHEEEEEHHHCCEEECCCHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCC
YQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
EEEECCCCCHHHHHHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHH
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCC
VNRDGTLKGYSLDVLSNTGAYVSHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAG
CCCCCCCCCEEEEEECCCCCHHCCCCCHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCC
AMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNASREGDANPLTGKRIYSAGLPECL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCHHHH
EKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
HHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEE
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPAL
CCCCCHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
GQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHG
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
GMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCC
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
CCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]