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The map label for this gene is atpB

Identifier: 209696449

GI number: 209696449

Start: 3319447

End: 3320259

Strand: Reverse

Name: atpB

Synonym: VSAL_I3065

Alternate gene names: 209696449

Gene position: 3320259-3319447 (Counterclockwise)

Preceding gene: 209696450

Following gene: 209696448

Centisome position: 99.85

GC content: 40.84

Gene sequence:

>813_bases
ATGGCTGCGCCAGGCGAAGCGCTAACACAATCTGGATATATTGAGCATCACCTATCAAACCTGTCTCTTGCGAAACTAGG
TATGGTTGCTGATGAAACAAGCTTCTGGAACGTACATATCGATAGCCTGTTCTTTTCTGTGCTTACAGGGATGTTATTCC
TTTGGGTTTTTCGTTCTGTAGCAAAGAAAGCAACAACAGGAGTACCAGGAAAGCTACAATGTTTTGTTGAAATGGTCGTG
GAATTCGTTGCTGACAACGTTAAAGAAACTTTCCATGGACGCAATCCATTAGTTGCTCCACTGGCACTAACTATCTTCTG
CTGGGTTATTTTAATGAACTTGATGGATTTAATTCCAATCGATTTCTTACCATACTCTGCAGCGCATTGGTTAGGTATCC
CTTATCTTAAGGTGGTTCCTTCTGCTGATGTGAATATCACCATGGCAATGGCGTTAGGTGTTTTTGCGTTGATGATCTAT
TACAGCATCAAGGTTAAAGGACTTGGCGGGTTTGCTAAAGAATTAGCACTTCACCCGTTTAATCACCCAATCATGATTCC
ATTCAACCTATTATTGGAAGTTATTTCGTTATTAGCGAAGCCTCTTTCTTTAGGTATGCGCTTGTTTGGTAATATGTTTG
CTGGTGAGGTGGTGTTTATTCTTATTGCGGCAATGCTACCGTGGTATTTACAATGGGTAGGTGCACTACCTTGGGCTATC
TTCCACATTTTAGTTATTTTGATTCAGGCGTTCGTATTCATGATGTTGACAATCGTTTATCTGTCAATGGCTCATGAAGA
TCCTGATCATTAA

Upstream 100 bases:

>100_bases
AGGTGGAACTTGTTCCCCTCAAACTAACCTATTTGCTGGTACTGGGTATTAATATCTTTGCACCAGTTCTCTTTATTAAC
AACAGAAAATAGGAAAAGTT

Downstream 100 bases:

>100_bases
TTTTAATAAAATATATTTATCAATGGCACTTTGCCGACAACAACAAAACTGGAGAAAGTAAATGGAAACTTTACTGAGCT
TTTCTGCAATCGCCGTAGGC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAAPGEALTQSGYIEHHLSNLSLAKLGMVADETSFWNVHIDSLFFSVLTGMLFLWVFRSVAKKATTGVPGKLQCFVEMVV
EFVADNVKETFHGRNPLVAPLALTIFCWVILMNLMDLIPIDFLPYSAAHWLGIPYLKVVPSADVNITMAMALGVFALMIY
YSIKVKGLGGFAKELALHPFNHPIMIPFNLLLEVISLLAKPLSLGMRLFGNMFAGEVVFILIAAMLPWYLQWVGALPWAI
FHILVILIQAFVFMMLTIVYLSMAHEDPDH

Sequences:

>Translated_270_residues
MAAPGEALTQSGYIEHHLSNLSLAKLGMVADETSFWNVHIDSLFFSVLTGMLFLWVFRSVAKKATTGVPGKLQCFVEMVV
EFVADNVKETFHGRNPLVAPLALTIFCWVILMNLMDLIPIDFLPYSAAHWLGIPYLKVVPSADVNITMAMALGVFALMIY
YSIKVKGLGGFAKELALHPFNHPIMIPFNLLLEVISLLAKPLSLGMRLFGNMFAGEVVFILIAAMLPWYLQWVGALPWAI
FHILVILIQAFVFMMLTIVYLSMAHEDPDH
>Mature_269_residues
AAPGEALTQSGYIEHHLSNLSLAKLGMVADETSFWNVHIDSLFFSVLTGMLFLWVFRSVAKKATTGVPGKLQCFVEMVVE
FVADNVKETFHGRNPLVAPLALTIFCWVILMNLMDLIPIDFLPYSAAHWLGIPYLKVVPSADVNITMAMALGVFALMIYY
SIKVKGLGGFAKELALHPFNHPIMIPFNLLLEVISLLAKPLSLGMRLFGNMFAGEVVFILIAAMLPWYLQWVGALPWAIF
HILVILIQAFVFMMLTIVYLSMAHEDPDH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=268, Percent_Identity=62.3134328358209, Blast_Score=327, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ALISL (B6EHU3)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002264380.1
- GeneID:   6988281
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I3065
- HOGENOM:   HBG734175
- OMA:   HGHETSA
- ProtClustDB:   PRK05815
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 30114; Mature: 29982

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2304f434)-; HASH(0x22411d6c)-; HASH(0x233d695c)-; HASH(0x22f69064)-; HASH(0x2255a580)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
AAPGEALTQSGYIEHHLSNLSLAKLGMVADETSFWNVHIDSLFFSVLTGMLFLWVFRSV
CCCCHHHHHCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKATTGVPGKLQCFVEMVVEFVADNVKETFHGRNPLVAPLALTIFCWVILMNLMDLIPI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DFLPYSAAHWLGIPYLKVVPSADVNITMAMALGVFALMIYYSIKVKGLGGFAKELALHPF
CCCCCCHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCC
NHPIMIPFNLLLEVISLLAKPLSLGMRLFGNMFAGEVVFILIAAMLPWYLQWVGALPWAI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHILVILIQAFVFMMLTIVYLSMAHEDPDH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA