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The map label for this gene is epsD [H]

Identifier: 209696322

GI number: 209696322

Start: 3166415

End: 3168442

Strand: Reverse

Name: epsD [H]

Synonym: VSAL_I2924

Alternate gene names: 209696322

Gene position: 3168442-3166415 (Counterclockwise)

Preceding gene: 209696323

Following gene: 209696321

Centisome position: 95.29

GC content: 41.67

Gene sequence:

>2028_bases
ATGGGCAAGGGAGCCTTATTACTGGCGAGTAGCATGGTGTGGACATCAGCTATCGCCAATGACTTTAGTGCCAGTTTTAA
AGGGACGGATATTCAAGAGTTCATCAACATTGTTGGTCGAAATTTGGAAAAAACCATTATTGTTGATCCTTCAGTACGCG
GAAAAGTGGATGTTCGTAGCTACGATTTATTGAATGAAGAACAATATTATCAATTCTTTTTAAGTGTCCTTGAAGTCTAT
GGCTACGCGGTCGTTGAAATGGATTCTGGTATTTTAAAAGTCATTAAAGATAAAGATGCGAAAACGTCGGCAGTTCCTGT
TCTGGGAGCAAAAGATAACATAACGGGTGATGCGGTAATTACTCGTGTTATTGCGGTTCGTAATGTCTCTGTACGTGAGC
TTTCACCTTTATTACGTCAGCTGAATGATAATGCGGGCGCGGGTAATGTGGTTCATTACGATCCGGCGAACATTATTATG
ATCACGGGTCGTGCGGCGGTGGTTAATCGCCTTGCTGAGATTATTGAACGAGTCGATCAGGCGGGTGATAAAGAAGTTGA
AGTGGTTGAGCTTAAAAATGCATCGGCGGCCGAGATGGTTCGTATTGTTGATGCTTTGAATAAAACAACGGAAGCAAAAA
ACACTCCGGCTTTCTTACAACCAAAATTGGTTGCCGATGAGCGAACTAACTCAGTATTAATTTCTGGGGATCCTAAAGTT
CGCCAACGATTGAAAAAATTAATTAAGCAACTTGATGTAGAAATGGCAACGAAAGGCAATAACCAAGTGGTTTACTTACG
CTATGCCAAAGCAGAAGATTTAGTTGATGTGCTTAAAGGGGTTTCTGACAATCTAGAAGCCGGTAAAGGAAGTGGCAAGC
AATCGGGTTCAAGTAATCGTGGTAATGTCATGATTTCAGCTCATGCGGATACTAATGCGATCATTATCACTGCACCGCCA
GATATTATGCGTGCAGTGAAAGATGTGATTGCTCAATTAGATATCCGTCGTGCTCAAGTATTAATTGAAGCGCTGATAGT
CGAAATGGCGGAAGGTGATGGCGTTAATCTTGGTGTGCAATGGGGTAATTTAAAAACCGGTGCAATGATCCAATACAGCA
ATACGGGGGCCTCAATTGGCGGCACCATGGTGGGCTTAGAAGAAGCTAAAGACAGCACCACGACAACCGCTGTTTATGAT
AGCGATGATAATTTCCAAAGAAATGAAACCACAACAGAAGAGGGTGATTACGGTGCACTTGCTTCTGCGCTTGGTGGTGT
TCAAGGCGCGGCGGTTAGTATTATGATGGGGGATTGGACTGCGTTGATAACGGCGGTATCGACTGATTCGAATTCAAATA
TTCTGTCATCACCAAGTATTACTGTCATGGATAATGGTGAAGCGTCATTTATTGTCGGTGAAGAAGTTCCTGTATTAACA
GGGTCTACCTCTGGTTCAAATAACGAGAACCCATTCCAAACCGTTGAACGTAAAGAAGTGGGTATTAAGCTTAAGGTGGT
CCCTCAGATTAATGAAGGGAACTCGGTTCGTTTGGATATTGAACAAGAAGTGTCTAATGTATTGGGTGCGAATGGGGCGG
TTGATGTTCGTTTTGCTAAGCGCCAGTTAAGTACGTCGGTCATGGTAGAAGATGGCAAAATGTTAGTACTGGGTGGTTTG
ATTGATGAACGAGCGATGGAAAGTGAATCAAAAGTTCCATTCCTTGGTGATATTCCGATTTTAGGCTATTTATTCAAATC
AACCAGCACTCAAGTTGAAAAGAAAAATTTAATGATATTCATTAAACCAACCATTATTCGTGATGGCATGACATCGGATG
GTATTACTCAGCGTAAATACAATTATATTCGTGCAGAGCAACTATATAATGCACAGAAAGGCTTGAAGTTTATGGATGAT
ACGAATATTCCGGTGTTACCAACATTTGATGAAGGCATAAAACACCCCGCTGAAATTCAAGCGTTCTTTGAACAGTTTGA
TGATGAACATAAGGATAAGGGAAAATAA

Upstream 100 bases:

>100_bases
TTAAATTTAACGGTTCAGCGTGATGGACAGTTACATGACATCTTTATCGGTCTATAAAAACTGGTAATTAATGAATTAAG
GGTATGTTGTGAAAAAGTGG

Downstream 100 bases:

>100_bases
TGGCGGACATGCTGTTTCCTCATTCTGTCGCGGTACTGCGTTTGCCTTTTTCATTTGCAAAAAGGCACTCAGTGGTTATT
GAACTCAGACCTGAAGGTTG

Product: general secretion pathway protein D

Products: NA

Alternate protein names: Cholera toxin secretion protein epsD [H]

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MGKGALLLASSMVWTSAIANDFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRSYDLLNEEQYYQFFLSVLEVY
GYAVVEMDSGILKVIKDKDAKTSAVPVLGAKDNITGDAVITRVIAVRNVSVRELSPLLRQLNDNAGAGNVVHYDPANIIM
ITGRAAVVNRLAEIIERVDQAGDKEVEVVELKNASAAEMVRIVDALNKTTEAKNTPAFLQPKLVADERTNSVLISGDPKV
RQRLKKLIKQLDVEMATKGNNQVVYLRYAKAEDLVDVLKGVSDNLEAGKGSGKQSGSSNRGNVMISAHADTNAIIITAPP
DIMRAVKDVIAQLDIRRAQVLIEALIVEMAEGDGVNLGVQWGNLKTGAMIQYSNTGASIGGTMVGLEEAKDSTTTTAVYD
SDDNFQRNETTTEEGDYGALASALGGVQGAAVSIMMGDWTALITAVSTDSNSNILSSPSITVMDNGEASFIVGEEVPVLT
GSTSGSNNENPFQTVERKEVGIKLKVVPQINEGNSVRLDIEQEVSNVLGANGAVDVRFAKRQLSTSVMVEDGKMLVLGGL
IDERAMESESKVPFLGDIPILGYLFKSTSTQVEKKNLMIFIKPTIIRDGMTSDGITQRKYNYIRAEQLYNAQKGLKFMDD
TNIPVLPTFDEGIKHPAEIQAFFEQFDDEHKDKGK

Sequences:

>Translated_675_residues
MGKGALLLASSMVWTSAIANDFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRSYDLLNEEQYYQFFLSVLEVY
GYAVVEMDSGILKVIKDKDAKTSAVPVLGAKDNITGDAVITRVIAVRNVSVRELSPLLRQLNDNAGAGNVVHYDPANIIM
ITGRAAVVNRLAEIIERVDQAGDKEVEVVELKNASAAEMVRIVDALNKTTEAKNTPAFLQPKLVADERTNSVLISGDPKV
RQRLKKLIKQLDVEMATKGNNQVVYLRYAKAEDLVDVLKGVSDNLEAGKGSGKQSGSSNRGNVMISAHADTNAIIITAPP
DIMRAVKDVIAQLDIRRAQVLIEALIVEMAEGDGVNLGVQWGNLKTGAMIQYSNTGASIGGTMVGLEEAKDSTTTTAVYD
SDDNFQRNETTTEEGDYGALASALGGVQGAAVSIMMGDWTALITAVSTDSNSNILSSPSITVMDNGEASFIVGEEVPVLT
GSTSGSNNENPFQTVERKEVGIKLKVVPQINEGNSVRLDIEQEVSNVLGANGAVDVRFAKRQLSTSVMVEDGKMLVLGGL
IDERAMESESKVPFLGDIPILGYLFKSTSTQVEKKNLMIFIKPTIIRDGMTSDGITQRKYNYIRAEQLYNAQKGLKFMDD
TNIPVLPTFDEGIKHPAEIQAFFEQFDDEHKDKGK
>Mature_674_residues
GKGALLLASSMVWTSAIANDFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRSYDLLNEEQYYQFFLSVLEVYG
YAVVEMDSGILKVIKDKDAKTSAVPVLGAKDNITGDAVITRVIAVRNVSVRELSPLLRQLNDNAGAGNVVHYDPANIIMI
TGRAAVVNRLAEIIERVDQAGDKEVEVVELKNASAAEMVRIVDALNKTTEAKNTPAFLQPKLVADERTNSVLISGDPKVR
QRLKKLIKQLDVEMATKGNNQVVYLRYAKAEDLVDVLKGVSDNLEAGKGSGKQSGSSNRGNVMISAHADTNAIIITAPPD
IMRAVKDVIAQLDIRRAQVLIEALIVEMAEGDGVNLGVQWGNLKTGAMIQYSNTGASIGGTMVGLEEAKDSTTTTAVYDS
DDNFQRNETTTEEGDYGALASALGGVQGAAVSIMMGDWTALITAVSTDSNSNILSSPSITVMDNGEASFIVGEEVPVLTG
STSGSNNENPFQTVERKEVGIKLKVVPQINEGNSVRLDIEQEVSNVLGANGAVDVRFAKRQLSTSVMVEDGKMLVLGGLI
DERAMESESKVPFLGDIPILGYLFKSTSTQVEKKNLMIFIKPTIIRDGMTSDGITQRKYNYIRAEQLYNAQKGLKFMDDT
NIPVLPTFDEGIKHPAEIQAFFEQFDDEHKDKGK

Specific function: Required for secretion of cholera toxin through the outer membrane [H]

COG id: COG1450

COG function: function code NU; Type II secretory pathway, component PulD

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family [H]

Homologues:

Organism=Escherichia coli, GI87082242, Length=661, Percent_Identity=42.6626323751891, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1789793, Length=351, Percent_Identity=23.9316239316239, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001775
- InterPro:   IPR005644
- InterPro:   IPR004846
- InterPro:   IPR013356
- InterPro:   IPR004845
- InterPro:   IPR001814 [H]

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N [H]

EC number: NA

Molecular weight: Translated: 73127; Mature: 72996

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00875 T2SP_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGALLLASSMVWTSAIANDFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRS
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEECC
YDLLNEEQYYQFFLSVLEVYGYAVVEMDSGILKVIKDKDAKTSAVPVLGAKDNITGDAVI
CCCCCHHHHHHHHHHHHHHHCEEEEEECCCCEEHHCCCCCCCCCEEEECCCCCCCHHHHH
TRVIAVRNVSVRELSPLLRQLNDNAGAGNVVHYDPANIIMITGRAAVVNRLAEIIERVDQ
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHC
AGDKEVEVVELKNASAAEMVRIVDALNKTTEAKNTPAFLQPKLVADERTNSVLISGDPKV
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEEECCHHH
RQRLKKLIKQLDVEMATKGNNQVVYLRYAKAEDLVDVLKGVSDNLEAGKGSGKQSGSSNR
HHHHHHHHHHHCCCEECCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GNVMISAHADTNAIIITAPPDIMRAVKDVIAQLDIRRAQVLIEALIVEMAEGDGVNLGVQ
CCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
WGNLKTGAMIQYSNTGASIGGTMVGLEEAKDSTTTTAVYDSDDNFQRNETTTEEGDYGAL
ECCCCCCEEEEECCCCCCCCCEEEEHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHH
ASALGGVQGAAVSIMMGDWTALITAVSTDSNSNILSSPSITVMDNGEASFIVGEEVPVLT
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCCEECCCCEEEEECCCEEEEECCCCEEEE
GSTSGSNNENPFQTVERKEVGIKLKVVPQINEGNSVRLDIEQEVSNVLGANGAVDVRFAK
CCCCCCCCCCHHHHHHHHHCCEEEEEEEEECCCCEEEEEHHHHHHHHHCCCCCEEEEEHH
RQLSTSVMVEDGKMLVLGGLIDERAMESESKVPFLGDIPILGYLFKSTSTQVEKKNLMIF
HHHCCEEEEECCCEEEEECHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCEECCCEEEE
IKPTIIRDGMTSDGITQRKYNYIRAEQLYNAQKGLKFMDDTNIPVLPTFDEGIKHPAEIQ
EECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEECCCHHHCCCHHHHH
AFFEQFDDEHKDKGK
HHHHHHCHHHCCCCC
>Mature Secondary Structure 
GKGALLLASSMVWTSAIANDFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGKVDVRS
CCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEECC
YDLLNEEQYYQFFLSVLEVYGYAVVEMDSGILKVIKDKDAKTSAVPVLGAKDNITGDAVI
CCCCCHHHHHHHHHHHHHHHCEEEEEECCCCEEHHCCCCCCCCCEEEECCCCCCCHHHHH
TRVIAVRNVSVRELSPLLRQLNDNAGAGNVVHYDPANIIMITGRAAVVNRLAEIIERVDQ
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHC
AGDKEVEVVELKNASAAEMVRIVDALNKTTEAKNTPAFLQPKLVADERTNSVLISGDPKV
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEEECCHHH
RQRLKKLIKQLDVEMATKGNNQVVYLRYAKAEDLVDVLKGVSDNLEAGKGSGKQSGSSNR
HHHHHHHHHHHCCCEECCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GNVMISAHADTNAIIITAPPDIMRAVKDVIAQLDIRRAQVLIEALIVEMAEGDGVNLGVQ
CCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
WGNLKTGAMIQYSNTGASIGGTMVGLEEAKDSTTTTAVYDSDDNFQRNETTTEEGDYGAL
ECCCCCCEEEEECCCCCCCCCEEEEHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHH
ASALGGVQGAAVSIMMGDWTALITAVSTDSNSNILSSPSITVMDNGEASFIVGEEVPVLT
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCCEECCCCEEEEECCCEEEEECCCCEEEE
GSTSGSNNENPFQTVERKEVGIKLKVVPQINEGNSVRLDIEQEVSNVLGANGAVDVRFAK
CCCCCCCCCCHHHHHHHHHCCEEEEEEEEECCCCEEEEEHHHHHHHHHCCCCCEEEEEHH
RQLSTSVMVEDGKMLVLGGLIDERAMESESKVPFLGDIPILGYLFKSTSTQVEKKNLMIF
HHHCCEEEEECCCEEEEECHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCEECCCEEEE
IKPTIIRDGMTSDGITQRKYNYIRAEQLYNAQKGLKFMDDTNIPVLPTFDEGIKHPAEIQ
EECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEECCCHHHCCCHHHHH
AFFEQFDDEHKDKGK
HHHHHHCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]