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The map label for this gene is ubiA

Identifier: 209696294

GI number: 209696294

Start: 3142377

End: 3143234

Strand: Reverse

Name: ubiA

Synonym: VSAL_I2895

Alternate gene names: 209696294

Gene position: 3143234-3142377 (Counterclockwise)

Preceding gene: 209696295

Following gene: 209696292

Centisome position: 94.53

GC content: 40.91

Gene sequence:

>858_bases
ATGACTCTGTCAAAAGCGAAGGCGTTTTGGCAATTAACGAGAATGAATCGTCCGATTGGCTCGTTGTTATTGTTATGGCC
AACATTGTGGGCTTTATTTTTGGCGGCTGATGGAATTCCAGATTGGCACGTACTGATTGTATTTATACTCGGTGTTGTAT
TTATGCGTTCGGCAGGGTGTGTCATTAATGATTTTGCTGATCGTAAAGTGGATGGTCATGTAAAGCGGACGGCTAATCGC
CCATTGCCTTCTGGATTAGTTTCTTCTAAAGAAGCACTTATTCTTTTTTCTGTATTGGTTACGTGTTCATTTATTCTGGT
TCTAACCATGAATACATTAACGATTATGTTATCGAGTATTGGGGTTTTGTTAGCGATCGCTTACCCGTTTATGAAACGCA
TCACGTATTTACCGCAATTTGTACTGGGATTGGCGTTTAGTTGGGCAATCCCGATGGCTTATGCGGCAGAATCAAATCAA
GTTCCGCCTGAGGCGTGGTTGTTGTTTGTGATTAATGCGGTATGGACAATTGCTTATGATACCCAATATGCAATGGTAGA
TAGAGATGATGACCTCAATATCGGTATCAAATCGACCGCGATTCTATTTGGACGTTTCGATAAGCTCATGATAGGCCTAC
TGCAACTGACCGTACTTACTTTATTGATAGCATTAGGTATACAGCTTTCGCTTCCAAGCCTATATAACTGGGGTGTCTTA
GCCGCTGCAGGGTGTTTTGTGTATCAACAATGGTTAATTAAAGGACGTGAAAGAGAGGCTTGTTTCGAAGCGTTTTTAAA
TAATAACTATGTGGGTGGTTTTATTTTTGTCGCCATAAGTGCGAGCGTACTTATTTAA

Upstream 100 bases:

>100_bases
ATGGAAAGCCAATGTTGGTGGCGGAATTATTTTTACCTAACGCATCTATTTATTCGGATAATTATTATTTAGAAAAAAAC
AATTCAAAGGGAAGTGAAGA

Downstream 100 bases:

>100_bases
TGACTTCAAAACTTTAAATTAGACGCATAAAAAAACCAGTACGTTTCGTGTACTGGTTTTTTATTATCTTAATATTAAGA
GATAGCTGATTTAGTCTTCT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTLSKAKAFWQLTRMNRPIGSLLLLWPTLWALFLAADGIPDWHVLIVFILGVVFMRSAGCVINDFADRKVDGHVKRTANR
PLPSGLVSSKEALILFSVLVTCSFILVLTMNTLTIMLSSIGVLLAIAYPFMKRITYLPQFVLGLAFSWAIPMAYAAESNQ
VPPEAWLLFVINAVWTIAYDTQYAMVDRDDDLNIGIKSTAILFGRFDKLMIGLLQLTVLTLLIALGIQLSLPSLYNWGVL
AAAGCFVYQQWLIKGREREACFEAFLNNNYVGGFIFVAISASVLI

Sequences:

>Translated_285_residues
MTLSKAKAFWQLTRMNRPIGSLLLLWPTLWALFLAADGIPDWHVLIVFILGVVFMRSAGCVINDFADRKVDGHVKRTANR
PLPSGLVSSKEALILFSVLVTCSFILVLTMNTLTIMLSSIGVLLAIAYPFMKRITYLPQFVLGLAFSWAIPMAYAAESNQ
VPPEAWLLFVINAVWTIAYDTQYAMVDRDDDLNIGIKSTAILFGRFDKLMIGLLQLTVLTLLIALGIQLSLPSLYNWGVL
AAAGCFVYQQWLIKGREREACFEAFLNNNYVGGFIFVAISASVLI
>Mature_284_residues
TLSKAKAFWQLTRMNRPIGSLLLLWPTLWALFLAADGIPDWHVLIVFILGVVFMRSAGCVINDFADRKVDGHVKRTANRP
LPSGLVSSKEALILFSVLVTCSFILVLTMNTLTIMLSSIGVLLAIAYPFMKRITYLPQFVLGLAFSWAIPMAYAAESNQV
PPEAWLLFVINAVWTIAYDTQYAMVDRDDDLNIGIKSTAILFGRFDKLMIGLLQLTVLTLLIALGIQLSLPSLYNWGVLA
AAGCFVYQQWLIKGREREACFEAFLNNNYVGGFIFVAISASVLI

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=276, Percent_Identity=34.4202898550725, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790473, Length=282, Percent_Identity=61.3475177304965, Blast_Score=339, Evalue=1e-94,
Organism=Escherichia coli, GI1786631, Length=226, Percent_Identity=24.3362831858407, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17553718, Length=282, Percent_Identity=34.0425531914894, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565247, Length=282, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17553720, Length=151, Percent_Identity=39.7350993377483, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32565245, Length=139, Percent_Identity=41.0071942446043, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32565243, Length=138, Percent_Identity=40.5797101449275, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=246, Percent_Identity=32.520325203252, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355567, Length=280, Percent_Identity=37.8571428571429, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_ALISL (B6ENU2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002264225.1
- GeneID:   6988987
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2895
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12848
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 31679; Mature: 31548

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20e659f4)-; HASH(0x22e65b30)-; HASH(0x22f52a7c)-; HASH(0x22f2db68)-; HASH(0x22f2be54)-; HASH(0x22693714)-; HASH(0x22f4f7c4)-; HASH(0x22f4f86c)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSKAKAFWQLTRMNRPIGSLLLLWPTLWALFLAADGIPDWHVLIVFILGVVFMRSAGC
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VINDFADRKVDGHVKRTANRPLPSGLVSSKEALILFSVLVTCSFILVLTMNTLTIMLSSI
EEEHHHCCCCCCHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLLAIAYPFMKRITYLPQFVLGLAFSWAIPMAYAAESNQVPPEAWLLFVINAVWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
TQYAMVDRDDDLNIGIKSTAILFGRFDKLMIGLLQLTVLTLLIALGIQLSLPSLYNWGVL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHH
AAAGCFVYQQWLIKGREREACFEAFLNNNYVGGFIFVAISASVLI
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCH
>Mature Secondary Structure 
TLSKAKAFWQLTRMNRPIGSLLLLWPTLWALFLAADGIPDWHVLIVFILGVVFMRSAGC
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VINDFADRKVDGHVKRTANRPLPSGLVSSKEALILFSVLVTCSFILVLTMNTLTIMLSSI
EEEHHHCCCCCCHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLLAIAYPFMKRITYLPQFVLGLAFSWAIPMAYAAESNQVPPEAWLLFVINAVWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
TQYAMVDRDDDLNIGIKSTAILFGRFDKLMIGLLQLTVLTLLIALGIQLSLPSLYNWGVL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHH
AAAGCFVYQQWLIKGREREACFEAFLNNNYVGGFIFVAISASVLI
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA