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The map label for this gene is cpxA [H]

Identifier: 209696204

GI number: 209696204

Start: 3029888

End: 3031276

Strand: Direct

Name: cpxA [H]

Synonym: VSAL_I2798

Alternate gene names: 209696204

Gene position: 3029888-3031276 (Clockwise)

Preceding gene: 209696203

Following gene: 209696205

Centisome position: 91.12

GC content: 41.68

Gene sequence:

>1389_bases
GTGAAAAAGTACCTAACCTTTCCCCTACTCTCTAGTCTTTATGGCCGTATTTTTGCCATTTTTTGGCTGACACTGTTACT
TGTTCTGATCGGCGTCGTTATTGGACCCAATTTTGATCCTCGTGATCGCCATGATATTGCCGCCGATCACCTCAGTAAAA
TGACTCAAATTGCGGCATATATTACAGGGAAATACTCAGAGAGTGATGATCTTAAAGCCGCATTAAAAGAGATCAGTCAC
AAAGCACACAATCACGACGAGAGCTTATCTCTATTTTTCACTACCCCAACAGGCGAGATATTAGATAAACCCAAAGAATT
ACGAGGCAGAAAAAAAGCCTTATTAAATTTCTTAACCTTATCGGATGATCCCAAACTTCCACAACAGAAATTGTATGCAA
GAACCATGATGGCTGGCCCATTTGATATCATTATCGCAAAAGAAACGGTTTATATGTACGTCGGACGCTATTGGAAAAAG
CCTCCCCCTTTTATTCTTCGAATTCTTGATAAACCAATACAATTACTGCTTGTCACCATGCTAATTAGTACCCCCTTTCT
GCTTTGGCTTGCATGGGCATTAAGCCAACCAGCAAGACGATTACAAAAAGCCGCTGAACGCGTTGCTAAAGGTCAATTTG
AACAAGATAAACGTTTAGAAAAAGGGCCTAAAGAATTCAGAAAAACAGGACAAAGCTTCAATCAAATGGTCGGTTCATTA
AATACCATGATCTCTGGACAACAGCGCTTATTATCTGATATTTCTCACGAACTGAGATCCCCACTGACTCGACTACGAAT
GGCAACCGCGCTTGCCACTCGAAAACAAGGGGAAAGCTCAGAACTATCACGTATCGATATGGAAGCAGAGCGCCTTGAGC
AAATGATATCGGAACTATTAGAGTTGTCTCGAATTCAAGTAAATAGCCATCAAGAACGAGAAGAAACAGACGCGTACTCA
CTGTGGTTTGATATTTTAGAAGACGCAAAATTTGAAGCGGAACACTTAAACAAAAATCTTACTTATTCGGGCCTTGAAGA
AATCGCCGTTTTTGGTAATCCAAACCTGTTAATGAGTGCGGTAGAAAACGTGATTCGAAATGCCATTAAGTATGGCAATG
ACATCATCACGATTAATTTAACGGAAAACCAAAAAACCATCACCATTCACGTGGATGATAATGGCGAAGGGGTCCCCGAT
GATGAGCTACAAGACATTTTCAAGCCTTTCTACCGAGTATCTACCGCCCGTGATAGAAGCAGCGGCGGCACTGGTTTGGG
ACTCGCAATAACAGAAAGTGCGATTCGCCAGCACAACGGGACAATACTCGCGAGTAAAAGTCCTCTAGGTGGATTGCGAA
TGACAATATCTTTACCGATATCTCATTAA

Upstream 100 bases:

>100_bases
TCTCTAATCTCAGAAAAAAATTGCCTCCATTAGCTGAAGGAAAACCACGAATTAAAACACTCCGTGGTCGTGGCTACTTA
TTTGTTGAGGAATAAATAAG

Downstream 100 bases:

>100_bases
TTTAGAGGTAGATGCCTATCTCTCTTAAAAGTGGATGAAAGATAAACACACCATGGATATACTGACACCACTTTCTATTT
TATTAAGACAACATTATGTT

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKKYLTFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRDRHDIAADHLSKMTQIAAYITGKYSESDDLKAALKEISH
KAHNHDESLSLFFTTPTGEILDKPKELRGRKKALLNFLTLSDDPKLPQQKLYARTMMAGPFDIIIAKETVYMYVGRYWKK
PPPFILRILDKPIQLLLVTMLISTPFLLWLAWALSQPARRLQKAAERVAKGQFEQDKRLEKGPKEFRKTGQSFNQMVGSL
NTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESSELSRIDMEAERLEQMISELLELSRIQVNSHQEREETDAYS
LWFDILEDAKFEAEHLNKNLTYSGLEEIAVFGNPNLLMSAVENVIRNAIKYGNDIITINLTENQKTITIHVDDNGEGVPD
DELQDIFKPFYRVSTARDRSSGGTGLGLAITESAIRQHNGTILASKSPLGGLRMTISLPISH

Sequences:

>Translated_462_residues
MKKYLTFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRDRHDIAADHLSKMTQIAAYITGKYSESDDLKAALKEISH
KAHNHDESLSLFFTTPTGEILDKPKELRGRKKALLNFLTLSDDPKLPQQKLYARTMMAGPFDIIIAKETVYMYVGRYWKK
PPPFILRILDKPIQLLLVTMLISTPFLLWLAWALSQPARRLQKAAERVAKGQFEQDKRLEKGPKEFRKTGQSFNQMVGSL
NTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESSELSRIDMEAERLEQMISELLELSRIQVNSHQEREETDAYS
LWFDILEDAKFEAEHLNKNLTYSGLEEIAVFGNPNLLMSAVENVIRNAIKYGNDIITINLTENQKTITIHVDDNGEGVPD
DELQDIFKPFYRVSTARDRSSGGTGLGLAITESAIRQHNGTILASKSPLGGLRMTISLPISH
>Mature_462_residues
MKKYLTFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRDRHDIAADHLSKMTQIAAYITGKYSESDDLKAALKEISH
KAHNHDESLSLFFTTPTGEILDKPKELRGRKKALLNFLTLSDDPKLPQQKLYARTMMAGPFDIIIAKETVYMYVGRYWKK
PPPFILRILDKPIQLLLVTMLISTPFLLWLAWALSQPARRLQKAAERVAKGQFEQDKRLEKGPKEFRKTGQSFNQMVGSL
NTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESSELSRIDMEAERLEQMISELLELSRIQVNSHQEREETDAYS
LWFDILEDAKFEAEHLNKNLTYSGLEEIAVFGNPNLLMSAVENVIRNAIKYGNDIITINLTENQKTITIHVDDNGEGVPD
DELQDIFKPFYRVSTARDRSSGGTGLGLAITESAIRQHNGTILASKSPLGGLRMTISLPISH

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=456, Percent_Identity=43.2017543859649, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI1787894, Length=335, Percent_Identity=28.6567164179104, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=31.0469314079422, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=30.0751879699248, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786783, Length=301, Percent_Identity=26.578073089701, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=27.1186440677966, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=28.310502283105, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=26.8, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1787374, Length=302, Percent_Identity=26.8211920529801, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=242, Percent_Identity=28.099173553719, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=28.125, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=24.3589743589744, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.9279279279279, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87081816, Length=115, Percent_Identity=30.4347826086957, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52296; Mature: 52296

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCEEHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCC
>Mature Secondary Structure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CCCCCEEHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]