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The map label for this gene is cpxR [H]

Identifier: 209696203

GI number: 209696203

Start: 3029199

End: 3029882

Strand: Direct

Name: cpxR [H]

Synonym: VSAL_I2797

Alternate gene names: 209696203

Gene position: 3029199-3029882 (Clockwise)

Preceding gene: 209696199

Following gene: 209696204

Centisome position: 91.1

GC content: 39.47

Gene sequence:

>684_bases
ATGGCAAAGATTTTATTGGTTGATGATGATGTAGAGCTAACCGCATTATTAAAAGATATTTTAAACTTAGAAGGCTACAC
CGTTGTTGAAGCCAATAATGGTATTGAGGGATTAAACGCCATTACCGATGATCTTGACCTTATTTTACTTGATATCATGA
TGCCTAAAATGAACGGCATGGACATGTTACGTAAACTGAGAGAAACCAACGAAACTCCCGTATTGATGCTGACCGCTAAA
GGCGAAGAAATTGATCGAGTGATCGGCCTAGAGTTAGGCGCCGATGATTACCTACCAAAGCCGTTCAGTGATAGAGAGCT
GCTTGCTAGAATTAGAGCAATCTTACGTCGCACTCAAGGTAAAACAAAAGAAAATCACACTAATAGCATTAAATATCAAG
GTATTGAGATATTTATAGGCAAGCAAGAAGCTTACAGCCATGGGGAATTGCTTGATCTTACAGGCACCGAATTTGGGTTA
CTGGCTCAATTTATACAAAACCCAGGCTCCATTATTTCAAAAGAAGAATTAAGCTTAGAAGTATTAGGAAAACGCCTCGC
GCCTTTTGATCGCGCAATTGACATGCACGTCTCTAATCTCAGAAAAAAATTGCCTCCATTAGCTGAAGGAAAACCACGAA
TTAAAACACTCCGTGGTCGTGGCTACTTATTTGTTGAGGAATAA

Upstream 100 bases:

>100_bases
GCTTGATGCGTAAATCAACGTAAAGGTGATTTTCAGCATTGGTATTCATCGTCATATTTGGCGATACTAAGACCATAAGA
GATAACTCAGGTGAATAGTA

Downstream 100 bases:

>100_bases
ATAAGGTGAAAAAGTACCTAACCTTTCCCCTACTCTCTAGTCTTTATGGCCGTATTTTTGCCATTTTTTGGCTGACACTG
TTACTTGTTCTGATCGGCGT

Product: CpxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MAKILLVDDDVELTALLKDILNLEGYTVVEANNGIEGLNAITDDLDLILLDIMMPKMNGMDMLRKLRETNETPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQGKTKENHTNSIKYQGIEIFIGKQEAYSHGELLDLTGTEFGL
LAQFIQNPGSIISKEELSLEVLGKRLAPFDRAIDMHVSNLRKKLPPLAEGKPRIKTLRGRGYLFVEE

Sequences:

>Translated_227_residues
MAKILLVDDDVELTALLKDILNLEGYTVVEANNGIEGLNAITDDLDLILLDIMMPKMNGMDMLRKLRETNETPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQGKTKENHTNSIKYQGIEIFIGKQEAYSHGELLDLTGTEFGL
LAQFIQNPGSIISKEELSLEVLGKRLAPFDRAIDMHVSNLRKKLPPLAEGKPRIKTLRGRGYLFVEE
>Mature_226_residues
AKILLVDDDVELTALLKDILNLEGYTVVEANNGIEGLNAITDDLDLILLDIMMPKMNGMDMLRKLRETNETPVLMLTAKG
EEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQGKTKENHTNSIKYQGIEIFIGKQEAYSHGELLDLTGTEFGLL
AQFIQNPGSIISKEELSLEVLGKRLAPFDRAIDMHVSNLRKKLPPLAEGKPRIKTLRGRGYLFVEE

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=58.9519650655022, Blast_Score=253, Evalue=5e-69,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=37.719298245614, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=37.6681614349776, Blast_Score=146, Evalue=9e-37,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=38.0530973451327, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=36.4035087719298, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=38.3928571428571, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=33.7662337662338, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=34.3891402714932, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=37.8260869565217, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=35.3448275862069, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=35.8078602620087, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=33.0396475770925, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=29.4642857142857, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.936170212766, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790437, Length=146, Percent_Identity=32.8767123287671, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=33.6, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=131, Percent_Identity=35.1145038167939, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25514; Mature: 25383

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILLVDDDVELTALLKDILNLEGYTVVEANNGIEGLNAITDDLDLILLDIMMPKMNGM
CEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
DMLRKLRETNETPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQG
HHHHHHHHCCCCCEEEEEECCCHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
KTKENHTNSIKYQGIEIFIGKQEAYSHGELLDLTGTEFGLLAQFIQNPGSIISKEELSLE
CCCCCCCCCEEECCEEEEEECHHCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHH
VLGKRLAPFDRAIDMHVSNLRKKLPPLAEGKPRIKTLRGRGYLFVEE
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEEC
>Mature Secondary Structure 
AKILLVDDDVELTALLKDILNLEGYTVVEANNGIEGLNAITDDLDLILLDIMMPKMNGM
EEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
DMLRKLRETNETPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQG
HHHHHHHHCCCCCEEEEEECCCHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
KTKENHTNSIKYQGIEIFIGKQEAYSHGELLDLTGTEFGLLAQFIQNPGSIISKEELSLE
CCCCCCCCCEEECCEEEEEECHHCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHH
VLGKRLAPFDRAIDMHVSNLRKKLPPLAEGKPRIKTLRGRGYLFVEE
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]