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The map label for this gene is frdA [H]

Identifier: 209696194

GI number: 209696194

Start: 3020995

End: 3022848

Strand: Direct

Name: frdA [H]

Synonym: VSAL_I2788

Alternate gene names: 209696194

Gene position: 3020995-3022848 (Clockwise)

Preceding gene: 209696192

Following gene: 209696195

Centisome position: 90.85

GC content: 44.07

Gene sequence:

>1854_bases
ATGATTAATTTAATTTTTTATCTTTTATCCCGGAGAATAACTGTGAAAACTATAACCACAGATATTGCAGTGATCGGCGC
GGGCGGTGCAGGTCTACGTACCGCTATAGCAGCAGCAGAAGCGAACCCAGAGCTAAACATTGCTCTAATCTCAAAAGTTT
ACCCAATGCGTTCGCACACTGTTGCCGCTGAAGGTGGATCCGCAGCCGTGACCAAGGAAGAAGATACACTAGACAATCAC
TTCAACGATACCGTTGGTGGTGGTGATTGGCTGTGTGAACAGGATGTTGTTGAATACTTTGTAAAAAATGCATACCGCGA
GATGACTCAATTAGAACAATGGGGTTGTCCTTGGAGCCGTAAAGAAAATGGCGAAGTAAACGTTCGTCGTTTTGGTGGTA
TGAAAGTTGAACGTACGTGGTTTGCTGCCGATAAAACGGGCTTCCACATGCTTCATACTCTGTTCCAAACTTCAATGAAA
TACCCTCAGATCAATCGTTATGATGAGTACTTCGTTGTCGATCTTCTTGTTGAAGATGGTCAAGTTCAAGGTTTGATTGC
TATTCACATGGCTGAAGGCGAACTTATCTGTATCAAAGCTAAATCTGTTGTTTTAGCAACGGGTGGCGCAGGTCGTGTTT
ACCACTGTAATACTAACGGCGGTATCGTAACTGGCGATGGTATGGCAATGGCGTATCGCCATGGTATCCCTCTGCGTGAT
ATGGAATTCGTTCAATACCACCCAACTGGCTTACCAGGTACTGGTATCTTGATGACTGAAGGTTGTCGTGGTGAAGGCGG
TATCATGATCAATAAAAATGGTTACCGTTACCTACAAGATTACGGTATGGGTCCAGAAACACCTATCGGTGAGCCAAAGA
ACAAATACATGGAACTGGGTCCTCGTGACAAAGTTTCACAAGCATTTTGGCATGAACTTCAAAAAGGCAACACTATTAAA
CACCCACTGGGTGATGTAGTGCATTTGGATCTTCGTCACCTAGGTGAAGAATACCTAAATGAGCGTCTTCCGTTTATCTG
TGAGCTATCAAAAGCTTACGTTAACGTTGATCCAGCTAAAGAACCAATCCCAATTCGCCCTACTGTTCACTACACCATGG
GTGGTATTGAAACGGATAAGAACAACGAAACAAACATCAAAGGCCTATTCGCGGTTGGTGAATGTTCATCTGTTGGTCTT
CACGGTGCAAACCGTTTAGGTTCAAACTCTCTAGCTGAGCTTGTTGTATTTGGTCGTCTTGCTGGTGAAAAAGCCGCTGA
ACGTGCCGCTGAATTCACAACTTGGAACGATGCTTCTATCCAAACTCAAATCGAAGCTGTTGAAGCTCGCATTGATGTTT
TACTAGCACAAGAAGGCGATGAAAACTGGGCTGATATCCGTACTGAAATGGGTCACTCAATGGAAGCGGGCTGTGGTATC
TACCGTAAAGAGCACGAAATGCAAGATACGGTTGATAAACTGGCTGAGCTGAAAAAACGTTACAAAAACATCAGCATCAA
AGACAAAGGAAAAGTATTCAATACTGACCTTTTATACGCTATCGAAGTGGGTTACGGCCTTGAAGTTGCTGAAGCAATGG
CTCACTCTGCCATTCAACGTAAAGAGTCTCGTGGTGCACACCAACGTTTAGATGAAGGTTGTACAGAACGTGATGATGTG
AATTACTTAAAACACTCATTAGCGTATTACAACGAAGATGCAGCGCCAACAATCAAGTACAGTGGCGTAACCATCACAAA
ATCTCAACCAAAAGCTCGCCTATATGGTGAAGCAGCAGAAAAAGCAGCAGCAGAAGAAGCTGCCGCGGCGAAAAACGCAG
AGGAGCAAGCATAA

Upstream 100 bases:

>100_bases
TCTAAAAGCTCACTTAGAATAGGCATCAGAATTTTTAAGTTATTATTTGCTCTTTTTTGTCACATGAGCAGGCTAGATTC
ACATAATTGATCATATTTGC

Downstream 100 bases:

>100_bases
TGACAGCTGGCAAGAGAGTCCAAAAAGTACACATTCTGCGTTATAACCCGATGACAGATTCAGAACCACATCTACAAACA
TTTGATGTGCCTTGTGATGA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MINLIFYLLSRRITVKTITTDIAVIGAGGAGLRTAIAAAEANPELNIALISKVYPMRSHTVAAEGGSAAVTKEEDTLDNH
FNDTVGGGDWLCEQDVVEYFVKNAYREMTQLEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMK
YPQINRYDEYFVVDLLVEDGQVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGIPLRD
MEFVQYHPTGLPGTGILMTEGCRGEGGIMINKNGYRYLQDYGMGPETPIGEPKNKYMELGPRDKVSQAFWHELQKGNTIK
HPLGDVVHLDLRHLGEEYLNERLPFICELSKAYVNVDPAKEPIPIRPTVHYTMGGIETDKNNETNIKGLFAVGECSSVGL
HGANRLGSNSLAELVVFGRLAGEKAAERAAEFTTWNDASIQTQIEAVEARIDVLLAQEGDENWADIRTEMGHSMEAGCGI
YRKEHEMQDTVDKLAELKKRYKNISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAIQRKESRGAHQRLDEGCTERDDV
NYLKHSLAYYNEDAAPTIKYSGVTITKSQPKARLYGEAAEKAAAEEAAAAKNAEEQA

Sequences:

>Translated_617_residues
MINLIFYLLSRRITVKTITTDIAVIGAGGAGLRTAIAAAEANPELNIALISKVYPMRSHTVAAEGGSAAVTKEEDTLDNH
FNDTVGGGDWLCEQDVVEYFVKNAYREMTQLEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMK
YPQINRYDEYFVVDLLVEDGQVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGIPLRD
MEFVQYHPTGLPGTGILMTEGCRGEGGIMINKNGYRYLQDYGMGPETPIGEPKNKYMELGPRDKVSQAFWHELQKGNTIK
HPLGDVVHLDLRHLGEEYLNERLPFICELSKAYVNVDPAKEPIPIRPTVHYTMGGIETDKNNETNIKGLFAVGECSSVGL
HGANRLGSNSLAELVVFGRLAGEKAAERAAEFTTWNDASIQTQIEAVEARIDVLLAQEGDENWADIRTEMGHSMEAGCGI
YRKEHEMQDTVDKLAELKKRYKNISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAIQRKESRGAHQRLDEGCTERDDV
NYLKHSLAYYNEDAAPTIKYSGVTITKSQPKARLYGEAAEKAAAEEAAAAKNAEEQA
>Mature_617_residues
MINLIFYLLSRRITVKTITTDIAVIGAGGAGLRTAIAAAEANPELNIALISKVYPMRSHTVAAEGGSAAVTKEEDTLDNH
FNDTVGGGDWLCEQDVVEYFVKNAYREMTQLEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMK
YPQINRYDEYFVVDLLVEDGQVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGIPLRD
MEFVQYHPTGLPGTGILMTEGCRGEGGIMINKNGYRYLQDYGMGPETPIGEPKNKYMELGPRDKVSQAFWHELQKGNTIK
HPLGDVVHLDLRHLGEEYLNERLPFICELSKAYVNVDPAKEPIPIRPTVHYTMGGIETDKNNETNIKGLFAVGECSSVGL
HGANRLGSNSLAELVVFGRLAGEKAAERAAEFTTWNDASIQTQIEAVEARIDVLLAQEGDENWADIRTEMGHSMEAGCGI
YRKEHEMQDTVDKLAELKKRYKNISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAIQRKESRGAHQRLDEGCTERDDV
NYLKHSLAYYNEDAAPTIKYSGVTITKSQPKARLYGEAAEKAAAEEAAAAKNAEEQA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=526, Percent_Identity=39.5437262357414, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=73.5395189003437, Blast_Score=882, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=540, Percent_Identity=41.8518518518518, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=31.6163410301954, Blast_Score=249, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=38.8278388278388, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17505833, Length=528, Percent_Identity=37.8787878787879, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71986328, Length=436, Percent_Identity=27.2935779816514, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322701, Length=558, Percent_Identity=39.247311827957, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322416, Length=558, Percent_Identity=38.7096774193548, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320788, Length=491, Percent_Identity=26.4765784114053, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137288, Length=582, Percent_Identity=38.4879725085911, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655642, Length=582, Percent_Identity=38.4879725085911, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655647, Length=582, Percent_Identity=38.4879725085911, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24663005, Length=542, Percent_Identity=37.4538745387454, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 68213; Mature: 68213

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINLIFYLLSRRITVKTITTDIAVIGAGGAGLRTAIAAAEANPELNIALISKVYPMRSHT
CHHHHEEHHCCCEEEEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEHHCCCCCCE
VAAEGGSAAVTKEEDTLDNHFNDTVGGGDWLCEQDVVEYFVKNAYREMTQLEQWGCPWSR
EEECCCCEEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYPQINRYDEYFVVDLLVEDG
CCCCCEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCC
QVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGIPLRD
CEEEEEEEEEECCCEEEEEECEEEEEECCCCEEEEECCCCCEEECCCEEEHHHCCCCCCC
MEFVQYHPTGLPGTGILMTEGCRGEGGIMINKNGYRYLQDYGMGPETPIGEPKNKYMELG
CCEEEECCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCC
PRDKVSQAFWHELQKGNTIKHPLGDVVHLDLRHLGEEYLNERLPFICELSKAYVNVDPAK
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHEEECCCCC
EPIPIRPTVHYTMGGIETDKNNETNIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRL
CCCCCCCEEEEEECCEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGEKAAERAAEFTTWNDASIQTQIEAVEARIDVLLAQEGDENWADIRTEMGHSMEAGCGI
HCHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHCCCHHHCCCH
YRKEHEMQDTVDKLAELKKRYKNISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAIQR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHH
KESRGAHQRLDEGCTERDDVNYLKHSLAYYNEDAAPTIKYSGVTITKSQPKARLYGEAAE
HHHCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHH
KAAAEEAAAAKNAEEQA
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MINLIFYLLSRRITVKTITTDIAVIGAGGAGLRTAIAAAEANPELNIALISKVYPMRSHT
CHHHHEEHHCCCEEEEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEHHCCCCCCE
VAAEGGSAAVTKEEDTLDNHFNDTVGGGDWLCEQDVVEYFVKNAYREMTQLEQWGCPWSR
EEECCCCEEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYPQINRYDEYFVVDLLVEDG
CCCCCEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCC
QVQGLIAIHMAEGELICIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGIPLRD
CEEEEEEEEEECCCEEEEEECEEEEEECCCCEEEEECCCCCEEECCCEEEHHHCCCCCCC
MEFVQYHPTGLPGTGILMTEGCRGEGGIMINKNGYRYLQDYGMGPETPIGEPKNKYMELG
CCEEEECCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCC
PRDKVSQAFWHELQKGNTIKHPLGDVVHLDLRHLGEEYLNERLPFICELSKAYVNVDPAK
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHEEECCCCC
EPIPIRPTVHYTMGGIETDKNNETNIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRL
CCCCCCCEEEEEECCEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGEKAAERAAEFTTWNDASIQTQIEAVEARIDVLLAQEGDENWADIRTEMGHSMEAGCGI
HCHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHCCCHHHCCCH
YRKEHEMQDTVDKLAELKKRYKNISIKDKGKVFNTDLLYAIEVGYGLEVAEAMAHSAIQR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHH
KESRGAHQRLDEGCTERDDVNYLKHSLAYYNEDAAPTIKYSGVTITKSQPKARLYGEAAE
HHHCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHH
KAAAEEAAAAKNAEEQA
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]