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The map label for this gene is hflK [H]

Identifier: 209696181

GI number: 209696181

Start: 3004512

End: 3005735

Strand: Reverse

Name: hflK [H]

Synonym: VSAL_I2775

Alternate gene names: 209696181

Gene position: 3005735-3004512 (Counterclockwise)

Preceding gene: 209696182

Following gene: 209696180

Centisome position: 90.39

GC content: 40.44

Gene sequence:

>1224_bases
ATGGCGTGGAATGAGCCTGGAAATAACAACAATAACGACAAGAACGGCGGTGGCGATAATAAAGACCCTTGGGGTAATAA
AAATCGTGGCGGTCGTGATCAAGGTCCACCAGATCTTGATGAAGTATTTAATAAGCTAAGCCAAAAACTAAGCGGTAAGT
TTGGTGGTGGCAATAAAGGAGGAAACAATAAAGGTGGCAGTGGCTTACCTTCATTTGGTAATGGTGGCGCAATTGGCTTA
GGTCTAATTGCTGTTGTCGCAATTGCTATCTGGATATTCTCTGGTTTCTATACGATTGGCGAGAGTGAGCGTGGTGTTGT
TCTACGTTTAGGCAAGTACGATCGTATGGTTGATCCAGGTCTTAACTGGAAACCAACCTTTATTGACCAAGTAACAGCTG
TAAACATTCAATCGATTCGTTCATTAAACTCAAAAGGGTTAATGCTAACAAAAGATGAAAATGTAGTCACAGTTGAAATG
GGTGTTCAATATCGAGTTGCTGACGCAAGGAAATATTTATATACCGTAGTTAATGCTGATGACAGTTTACGTCAAGCAAC
TGATTCTGCACTTCGTGCTGTAATCGGTGATGCTAAAATGGATGATATCTTGACCAGTGGTCGTCAAGTGATTCGTCAAC
GTACTCAAGAAACACTGAATCGTATTATTGATAAATACGATATGGGGTTAATTGTTGTAGACGTTAACTTCCAATTAGCT
CGTCCGCCGGAAGAAGTGAAAGCGTCGTTCGATGATGCTATCGCAGCTCGAGAAGATGAAGAGCGTTTTATTCGTGAAGC
AGAAGCGTACAGTAATGATATTCTTCCTAAAGCGACAGGTCGTGCTGAGCGTTTGAAGAAAGAAGCTCAAGGTTATACTG
AACGTACCGTCAACGGAGCTATTGGTCAAATTGCTCAGTTTGAAAAGCTGTTACCTGAATACAATAAAGCGCCTGAAGTC
ACTCGTACTCGTCTGTATCTTGATACGATGGAACGTGTATACAGTAATACAAGTAAGGTTCTGATTGATTCTGAATCTAA
TGGTAACTTGTTGTATCTTCCATTAGATAAGATGGTAGGCAATCAACAAGGGTCTGCTAAAGTTTCTCCTCAAACATCAA
CATCATCATCTAAAAATTATGATTTTGAGTTAGAGAAAAATGGACAACCAGATCCAAAAGCGAATACTACAAGCCGTACT
TCAACTCGTGAAGGGAGATATTAA

Upstream 100 bases:

>100_bases
TAAGTTAGAAAAACGTGAAGAGACTCCGTTAAGTTATTTTTTAATGACTGACGAGAGTACACCGAATTCTTTATCTTCAT
AATTACTTTGGAGTTTTCTA

Downstream 100 bases:

>100_bases
TCATGCGTAAGTTAATGATCCCAACGCTTATCGTTGTTATCGCTATTTTCTTAATGTCACTATTTGTGATCCCAGAAGGC
GAACGCGGAATAGTTACTCG

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MAWNEPGNNNNNDKNGGGDNKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNKGGNNKGGSGLPSFGNGGAIGL
GLIAVVAIAIWIFSGFYTIGESERGVVLRLGKYDRMVDPGLNWKPTFIDQVTAVNIQSIRSLNSKGLMLTKDENVVTVEM
GVQYRVADARKYLYTVVNADDSLRQATDSALRAVIGDAKMDDILTSGRQVIRQRTQETLNRIIDKYDMGLIVVDVNFQLA
RPPEEVKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERTVNGAIGQIAQFEKLLPEYNKAPEV
TRTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKMVGNQQGSAKVSPQTSTSSSKNYDFELEKNGQPDPKANTTSRT
STREGRY

Sequences:

>Translated_407_residues
MAWNEPGNNNNNDKNGGGDNKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNKGGNNKGGSGLPSFGNGGAIGL
GLIAVVAIAIWIFSGFYTIGESERGVVLRLGKYDRMVDPGLNWKPTFIDQVTAVNIQSIRSLNSKGLMLTKDENVVTVEM
GVQYRVADARKYLYTVVNADDSLRQATDSALRAVIGDAKMDDILTSGRQVIRQRTQETLNRIIDKYDMGLIVVDVNFQLA
RPPEEVKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERTVNGAIGQIAQFEKLLPEYNKAPEV
TRTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKMVGNQQGSAKVSPQTSTSSSKNYDFELEKNGQPDPKANTTSRT
STREGRY
>Mature_406_residues
AWNEPGNNNNNDKNGGGDNKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNKGGNNKGGSGLPSFGNGGAIGLG
LIAVVAIAIWIFSGFYTIGESERGVVLRLGKYDRMVDPGLNWKPTFIDQVTAVNIQSIRSLNSKGLMLTKDENVVTVEMG
VQYRVADARKYLYTVVNADDSLRQATDSALRAVIGDAKMDDILTSGRQVIRQRTQETLNRIIDKYDMGLIVVDVNFQLAR
PPEEVKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERTVNGAIGQIAQFEKLLPEYNKAPEVT
RTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKMVGNQQGSAKVSPQTSTSSSKNYDFELEKNGQPDPKANTTSRTS
TREGRY

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=369, Percent_Identity=55.8265582655827, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1786697, Length=218, Percent_Identity=26.605504587156, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18860517, Length=149, Percent_Identity=29.5302013422819, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 44823; Mature: 44691

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGNNNNNDKNGGGDNKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GNNKGGSGLPSFGNGGAIGLGLIAVVAIAIWIFSGFYTIGESERGVVLRLGKYDRMVDPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCC
LNWKPTFIDQVTAVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYRVADARKYLYTVVNAD
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCEEEEHHHHEEEEEEECCC
DSLRQATDSALRAVIGDAKMDDILTSGRQVIRQRTQETLNRIIDKYDMGLIVVDVNFQLA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEC
RPPEEVKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERTVNGA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
IGQIAQFEKLLPEYNKAPEVTRTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKMVG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHC
NQQGSAKVSPQTSTSSSKNYDFELEKNGQPDPKANTTSRTSTREGRY
CCCCCCEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWNEPGNNNNNDKNGGGDNKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GNNKGGSGLPSFGNGGAIGLGLIAVVAIAIWIFSGFYTIGESERGVVLRLGKYDRMVDPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCC
LNWKPTFIDQVTAVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYRVADARKYLYTVVNAD
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCEEEEHHHHEEEEEEECCC
DSLRQATDSALRAVIGDAKMDDILTSGRQVIRQRTQETLNRIIDKYDMGLIVVDVNFQLA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEC
RPPEEVKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERTVNGA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
IGQIAQFEKLLPEYNKAPEVTRTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKMVG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHC
NQQGSAKVSPQTSTSSSKNYDFELEKNGQPDPKANTTSRTSTREGRY
CCCCCCEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]