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The map label for this gene is hflC [H]

Identifier: 209696180

GI number: 209696180

Start: 3003625

End: 3004509

Strand: Reverse

Name: hflC [H]

Synonym: VSAL_I2774

Alternate gene names: 209696180

Gene position: 3004509-3003625 (Counterclockwise)

Preceding gene: 209696181

Following gene: 209696179

Centisome position: 90.36

GC content: 39.55

Gene sequence:

>885_bases
ATGCGTAAGTTAATGATCCCAACGCTTATCGTTGTTATCGCTATTTTCTTAATGTCACTATTTGTGATCCCAGAAGGCGA
ACGCGGAATAGTTACTCGATTTGGCCGTTTGATTAAAGATGATAATCAAGTTACACGTATTTATGAACCTGGTCTGCACT
TTAAAATGCCAATGTTCGATCGTGTAAATACATTAGATGCTCGTATTCAAACAATGGATGACCAGTCAGACCGTTTTGTA
ACATCAGAGAAAAAAGACGTTATTATCGACTCGTATGTTAAATGGAAGATCAAAGACTTTGGTCAATTCTATCTAGCAAC
AGGTGGTGGTAATATCTTAACGGCAGAGTCATTATTACAACGTCGTGTATCTGATGGTCTACGAGCTGAGATCGGCGGAA
AAACAGTGAAAGAGATCGTTTCTGAGAAACGTGAAGAAGTAATGGCAACAGTACTTCTTGACTCTCAAGAAGGAACGGGT
GATTTAGGGATTGAAGTGATTGATTTACGAATCAAGAAAATCAACTTACCTGAAGAAATCTCTGAGTCGATTTACCGTCG
TATGCGTGCAGAGCGTGAAGCGGTTGCTCGTAAGTTACGTTCTCAAGGTCGTGAAAAAGCCGAAGTTATTCGTGCTCAAT
CAGAACTTGAAGTGGCTACTATCATTGCAGAAGCAGATAAAACAGCACAAATTACTCGTGGTAATGCGGATGCGAAAGTA
GCAAAACTGTACGCTGATACGTTTAACAAAGAGCCTGAGCTCTTTGGTTTCATTCGCTCATTACGTGCGTATGAAAAATC
ATTCAACAGTAAGAATGACATCTTGGTACTTGATCCTAAGACTGATTTCTTCAAATACATGAATGATCCAATGGGTGGGA
AATAA

Upstream 100 bases:

>100_bases
CATCTAAAAATTATGATTTTGAGTTAGAGAAAAATGGACAACCAGATCCAAAAGCGAATACTACAAGCCGTACTTCAACT
CGTGAAGGGAGATATTAATC

Downstream 100 bases:

>100_bases
GTCTAGTTCTAGATTTTAATTCACTCTAATTTAAACAAGGTCCTTCGGGACCTTGTTTTGTTTCTGCTCGATAGATAAGG
GTACATAATGAGTAATGCAG

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRKLMIPTLIVVIAIFLMSLFVIPEGERGIVTRFGRLIKDDNQVTRIYEPGLHFKMPMFDRVNTLDARIQTMDDQSDRFV
TSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAESLLQRRVSDGLRAEIGGKTVKEIVSEKREEVMATVLLDSQEGTG
DLGIEVIDLRIKKINLPEEISESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTAQITRGNADAKV
AKLYADTFNKEPELFGFIRSLRAYEKSFNSKNDILVLDPKTDFFKYMNDPMGGK

Sequences:

>Translated_294_residues
MRKLMIPTLIVVIAIFLMSLFVIPEGERGIVTRFGRLIKDDNQVTRIYEPGLHFKMPMFDRVNTLDARIQTMDDQSDRFV
TSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAESLLQRRVSDGLRAEIGGKTVKEIVSEKREEVMATVLLDSQEGTG
DLGIEVIDLRIKKINLPEEISESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTAQITRGNADAKV
AKLYADTFNKEPELFGFIRSLRAYEKSFNSKNDILVLDPKTDFFKYMNDPMGGK
>Mature_294_residues
MRKLMIPTLIVVIAIFLMSLFVIPEGERGIVTRFGRLIKDDNQVTRIYEPGLHFKMPMFDRVNTLDARIQTMDDQSDRFV
TSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAESLLQRRVSDGLRAEIGGKTVKEIVSEKREEVMATVLLDSQEGTG
DLGIEVIDLRIKKINLPEEISESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTAQITRGNADAKV
AKLYADTFNKEPELFGFIRSLRAYEKSFNSKNDILVLDPKTDFFKYMNDPMGGK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=329, Percent_Identity=50.1519756838906, Blast_Score=318, Evalue=2e-88,
Organism=Escherichia coli, GI1786697, Length=244, Percent_Identity=24.1803278688525, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193209764, Length=195, Percent_Identity=26.1538461538462, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17569493, Length=191, Percent_Identity=26.1780104712042, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 33466; Mature: 33466

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLMIPTLIVVIAIFLMSLFVIPEGERGIVTRFGRLIKDDNQVTRIYEPGLHFKMPMFD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEECCHHH
RVNTLDARIQTMDDQSDRFVTSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAESLLQ
HHHHHHHHHHHCCCCCCCEECCCCCCEEEEHHHHEEEECCCEEEEEECCCCEEHHHHHHH
RRVSDGLRAEIGGKTVKEIVSEKREEVMATVLLDSQEGTGDLGIEVIDLRIKKINLPEEI
HHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEEEEEECCCHHHH
SESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTAQITRGNADAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
AKLYADTFNKEPELFGFIRSLRAYEKSFNSKNDILVLDPKTDFFKYMNDPMGGK
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MRKLMIPTLIVVIAIFLMSLFVIPEGERGIVTRFGRLIKDDNQVTRIYEPGLHFKMPMFD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEECCHHH
RVNTLDARIQTMDDQSDRFVTSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAESLLQ
HHHHHHHHHHHCCCCCCCEECCCCCCEEEEHHHHEEEECCCEEEEEECCCCEEHHHHHHH
RRVSDGLRAEIGGKTVKEIVSEKREEVMATVLLDSQEGTGDLGIEVIDLRIKKINLPEEI
HHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEEEEEECCCHHHH
SESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTAQITRGNADAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
AKLYADTFNKEPELFGFIRSLRAYEKSFNSKNDILVLDPKTDFFKYMNDPMGGK
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]