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The map label for this gene is ftsI [H]

Identifier: 209696058

GI number: 209696058

Start: 2868772

End: 2870511

Strand: Reverse

Name: ftsI [H]

Synonym: VSAL_I2650

Alternate gene names: 209696058

Gene position: 2870511-2868772 (Counterclockwise)

Preceding gene: 209696059

Following gene: 209696057

Centisome position: 86.33

GC content: 43.28

Gene sequence:

>1740_bases
ATGAAATTACCAAGTAGAAAGACAAATAATAAACGTATAAGCAAAGCGCCACCGACTTTAATTCAGTGGCGCTTTGGCGT
TATTGTTTTTTTTGTTTTTCTTGCTTTGGCTATTTTGATTGCTCGTGCGGCTTATATTCAAGTAATAGAACCAGATAACC
TTATTAAACAAGGTGATATGCGTTCTATTCGAGTTAAGACAATGCCTTCTGCTCGCGGTATTATTTCAGACCGAAATGAT
GAGCAACTTGCGGTGAGTGTTCCTGTTGATGCGGTGTGGGCTGATCCTGTCGCGATCTATAAAGCGGGCGGTTTAGTTGA
AGTTGATCGTTGGCATGCTCTGGCTGATGTTCTTGGTTTAAAACGTACCGAATTACTCTCCAAAATAGAAAAGAATAAAA
AACGCCGTTTTATCTATCTTCAGCGTCAAATTTCCCCTGCGGTTGCTGCTTATATTCGAAAATTAAAACTCGCTGGTATT
GGTTTAAAAGCGGAATCTCGTCGGTATTATCCTTCGGGTGAGATCAGTGCTCACGTTATTGGTGTGACGGGGATTGATAG
CCACGGCCTTGAAGGTGTGGAGCGAAGCTATGATGGCTGGCTAACTGGTGAACCAGGTCGTCGTACAGTGCGAAAAGATC
GTTATGGTCGAGTGGTTGAAAATATTTCGTTAAAAGAGAAACAAGAAGGTAAGCCATTAACGTTAAGTATTGATCAACGT
TTACAAGCGATTGCTTATCGTGCGATTAAACAAGCCGTTTCAGACTTTAGAGCCATGTCGGGTTCTGTTGTCATGATTGA
TATTAAAACGGGTGAAGTATTAGCAATGGTTAATGCCCCGTCTTATAACCCAAATGACAGAAGTCAGTTACAAAACTTTA
GAATGCGAAATCGTGTTATTACCGATACGTTAGAGCCAGGCTCAACCGTTAAACCTTTTGTCGTATTAGCGGCGCTTGAT
AGTGGCACTGCAAACCTAAATACGATTGTGGATACCGGTAATGGCATTATGCGAATTGGTGGAAGTCGAGTTCGTGATAG
CTCTAAAGTGGGTAAAGCGAACTTAACTACTATTTTAAAAAAATCGAGTAACATCGGTGTGGCGCACTTGGCGTTAAATA
TGCCCTTACAAGAACTATTGGCGGAATACAGTGCGGTTGGTTTGGCAGATCCTTCTGGATTAAGTTTGATTGGTGAAGCG
ACGGGTATATTCCCTGATCGCCGTCGTTGGTCTGATTTTGAAATTGCCACTCTTGCATTTGGTTACGGCCTTTCTGTTAC
TCCCATTCAGTTAGCTCATGCGTATGCAACATTGGGTGCTTATGGTGAATATCGTCCGCTTTCTATTTTGAAAACGACGG
GACCCACTCCGGGTAAACAAGTGGTTAATCGTGAACACGCTAAAGCGGTATTAGCGATGATGGAAACGGTAACTCAACCT
GGAGGTACAGCGACTAAAGCGGCCGTTCCTGGATACCGAGTTGCTGCGAAAACAGGGACATCTCGTAAAGCGGTTCGCGG
TGGCTACAGTGATGAATATATGACGGTAACCGCGGGTGTTGCTCCGGTAAGTAATCCTCGAATTGCTCTGGTGACGATCG
TGAATCAACCGCAAGGCGATGAATATTATGCGGGTCAAGTCGCTGCGCCTATTTTTGGTCAGGTGATGAAAGATGCATTA
CAAATATTAAATGTAGCCCCAGACGAAAGTACCGTAAAACATATCGATGTATTGAATTAG

Upstream 100 bases:

>100_bases
AAAGTGCACTCGCAGAGCATAGTCGAGTGCAGTCTCGTTCCATACGCGAATTAGATATGGAAAGACCCTCCCCGGATAAA
GAAGTCATAATAAAACTACG

Downstream 100 bases:

>100_bases
GAAAAGGATGATGCAGTTATCTGAATTATTGTTGCCTTGGTGTGAATTAAATCAAGTCGTAGAAATATCATCCATGACAT
TGGACAGTCGTAAAGTAACC

Product: peptidoglycan synthetase FtsI precursor (peptidoglycan glycosyltransferase 3) (penicillin-binding protein 3)

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MKLPSRKTNNKRISKAPPTLIQWRFGVIVFFVFLALAILIARAAYIQVIEPDNLIKQGDMRSIRVKTMPSARGIISDRND
EQLAVSVPVDAVWADPVAIYKAGGLVEVDRWHALADVLGLKRTELLSKIEKNKKRRFIYLQRQISPAVAAYIRKLKLAGI
GLKAESRRYYPSGEISAHVIGVTGIDSHGLEGVERSYDGWLTGEPGRRTVRKDRYGRVVENISLKEKQEGKPLTLSIDQR
LQAIAYRAIKQAVSDFRAMSGSVVMIDIKTGEVLAMVNAPSYNPNDRSQLQNFRMRNRVITDTLEPGSTVKPFVVLAALD
SGTANLNTIVDTGNGIMRIGGSRVRDSSKVGKANLTTILKKSSNIGVAHLALNMPLQELLAEYSAVGLADPSGLSLIGEA
TGIFPDRRRWSDFEIATLAFGYGLSVTPIQLAHAYATLGAYGEYRPLSILKTTGPTPGKQVVNREHAKAVLAMMETVTQP
GGTATKAAVPGYRVAAKTGTSRKAVRGGYSDEYMTVTAGVAPVSNPRIALVTIVNQPQGDEYYAGQVAAPIFGQVMKDAL
QILNVAPDESTVKHIDVLN

Sequences:

>Translated_579_residues
MKLPSRKTNNKRISKAPPTLIQWRFGVIVFFVFLALAILIARAAYIQVIEPDNLIKQGDMRSIRVKTMPSARGIISDRND
EQLAVSVPVDAVWADPVAIYKAGGLVEVDRWHALADVLGLKRTELLSKIEKNKKRRFIYLQRQISPAVAAYIRKLKLAGI
GLKAESRRYYPSGEISAHVIGVTGIDSHGLEGVERSYDGWLTGEPGRRTVRKDRYGRVVENISLKEKQEGKPLTLSIDQR
LQAIAYRAIKQAVSDFRAMSGSVVMIDIKTGEVLAMVNAPSYNPNDRSQLQNFRMRNRVITDTLEPGSTVKPFVVLAALD
SGTANLNTIVDTGNGIMRIGGSRVRDSSKVGKANLTTILKKSSNIGVAHLALNMPLQELLAEYSAVGLADPSGLSLIGEA
TGIFPDRRRWSDFEIATLAFGYGLSVTPIQLAHAYATLGAYGEYRPLSILKTTGPTPGKQVVNREHAKAVLAMMETVTQP
GGTATKAAVPGYRVAAKTGTSRKAVRGGYSDEYMTVTAGVAPVSNPRIALVTIVNQPQGDEYYAGQVAAPIFGQVMKDAL
QILNVAPDESTVKHIDVLN
>Mature_579_residues
MKLPSRKTNNKRISKAPPTLIQWRFGVIVFFVFLALAILIARAAYIQVIEPDNLIKQGDMRSIRVKTMPSARGIISDRND
EQLAVSVPVDAVWADPVAIYKAGGLVEVDRWHALADVLGLKRTELLSKIEKNKKRRFIYLQRQISPAVAAYIRKLKLAGI
GLKAESRRYYPSGEISAHVIGVTGIDSHGLEGVERSYDGWLTGEPGRRTVRKDRYGRVVENISLKEKQEGKPLTLSIDQR
LQAIAYRAIKQAVSDFRAMSGSVVMIDIKTGEVLAMVNAPSYNPNDRSQLQNFRMRNRVITDTLEPGSTVKPFVVLAALD
SGTANLNTIVDTGNGIMRIGGSRVRDSSKVGKANLTTILKKSSNIGVAHLALNMPLQELLAEYSAVGLADPSGLSLIGEA
TGIFPDRRRWSDFEIATLAFGYGLSVTPIQLAHAYATLGAYGEYRPLSILKTTGPTPGKQVVNREHAKAVLAMMETVTQP
GGTATKAAVPGYRVAAKTGTSRKAVRGGYSDEYMTVTAGVAPVSNPRIALVTIVNQPQGDEYYAGQVAAPIFGQVMKDAL
QILNVAPDESTVKHIDVLN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=566, Percent_Identity=51.5901060070671, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786854, Length=603, Percent_Identity=26.6998341625207, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 62988; Mature: 62988

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPSRKTNNKRISKAPPTLIQWRFGVIVFFVFLALAILIARAAYIQVIEPDNLIKQGDM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHCCCCC
RSIRVKTMPSARGIISDRNDEQLAVSVPVDAVWADPVAIYKAGGLVEVDRWHALADVLGL
CEEEEEECCCCCCCCCCCCCCEEEEECCCCEEECCCEEEEECCCEEEEHHHHHHHHHHCC
KRTELLSKIEKNKKRRFIYLQRQISPAVAAYIRKLKLAGIGLKAESRRYYPSGEISAHVI
HHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
GVTGIDSHGLEGVERSYDGWLTGEPGRRTVRKDRYGRVVENISLKEKQEGKPLTLSIDQR
EEECCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCEEEEHHHH
LQAIAYRAIKQAVSDFRAMSGSVVMIDIKTGEVLAMVNAPSYNPNDRSQLQNFRMRNRVI
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCE
TDTLEPGSTVKPFVVLAALDSGTANLNTIVDTGNGIMRIGGSRVRDSSKVGKANLTTILK
EECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHH
KSSNIGVAHLALNMPLQELLAEYSAVGLADPSGLSLIGEATGIFPDRRRWSDFEIATLAF
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEE
GYGLSVTPIQLAHAYATLGAYGEYRPLSILKTTGPTPGKQVVNREHAKAVLAMMETVTQP
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GGTATKAAVPGYRVAAKTGTSRKAVRGGYSDEYMTVTAGVAPVSNPRIALVTIVNQPQGD
CCCCCCCCCCCEEEEECCCCCCHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCC
EYYAGQVAAPIFGQVMKDALQILNVAPDESTVKHIDVLN
CEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCC
>Mature Secondary Structure
MKLPSRKTNNKRISKAPPTLIQWRFGVIVFFVFLALAILIARAAYIQVIEPDNLIKQGDM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHCCCCC
RSIRVKTMPSARGIISDRNDEQLAVSVPVDAVWADPVAIYKAGGLVEVDRWHALADVLGL
CEEEEEECCCCCCCCCCCCCCEEEEECCCCEEECCCEEEEECCCEEEEHHHHHHHHHHCC
KRTELLSKIEKNKKRRFIYLQRQISPAVAAYIRKLKLAGIGLKAESRRYYPSGEISAHVI
HHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
GVTGIDSHGLEGVERSYDGWLTGEPGRRTVRKDRYGRVVENISLKEKQEGKPLTLSIDQR
EEECCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCEEEEHHHH
LQAIAYRAIKQAVSDFRAMSGSVVMIDIKTGEVLAMVNAPSYNPNDRSQLQNFRMRNRVI
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCE
TDTLEPGSTVKPFVVLAALDSGTANLNTIVDTGNGIMRIGGSRVRDSSKVGKANLTTILK
EECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHH
KSSNIGVAHLALNMPLQELLAEYSAVGLADPSGLSLIGEATGIFPDRRRWSDFEIATLAF
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEE
GYGLSVTPIQLAHAYATLGAYGEYRPLSILKTTGPTPGKQVVNREHAKAVLAMMETVTQP
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GGTATKAAVPGYRVAAKTGTSRKAVRGGYSDEYMTVTAGVAPVSNPRIALVTIVNQPQGD
CCCCCCCCCCCEEEEECCCCCCHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCC
EYYAGQVAAPIFGQVMKDALQILNVAPDESTVKHIDVLN
CEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]