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The map label for this gene is panC

Identifier: 209696023

GI number: 209696023

Start: 2825739

End: 2826635

Strand: Direct

Name: panC

Synonym: VSAL_I2610

Alternate gene names: 209696023

Gene position: 2825739-2826635 (Clockwise)

Preceding gene: 209696022

Following gene: 209696028

Centisome position: 84.98

GC content: 40.47

Gene sequence:

>897_bases
ATGGAAATTTTTGCCGATATTTTACCATTGCGCGAGCAAATAAAAACATGGAAACGAGAAGGAAAGCGTATTGCTTTTAT
TCCTACGATGGGAAATTTGCATGAGGGCCATCTTACTTTAGTACGAACTGCCCGAGAACATGCTGATATTATTGTCGCTA
GTATTTTTGTAAATCCAATGCAGTTTAATAATGTTGATGATTTAACAAACTACCCTCGTACAATAGATGAAGATATTGAA
AAGCTAACCTCAGAAAATGTGGATATGCTTTTTACTCCCACGCCAGAAGTCATGTATCCCGACGGTTTAGATAAACAGAC
GGTTGTCGATGTTCCTGTAATTTCAACGATTCTAGAGGGCGCGTCTCGACCTGGTCACTTTAAAGGTGTATCAACAGTCG
TTGCGAAACTATTTAATATCGTTCAACCTGACGTTGCTTGTTTTGGTGAAAAAGATTTCCAGCAATTAGCGCTAATTCGT
CAAATGGTTATTGATATGGCCATGGATATTGATGTCGTTGGTGTTGCTACCGTTCGAGAAATGGATGGATTAGCAATGAG
CTCTCGCAATAACTTGCTTACATTGAATGAACGCCAACGCTCACCGGTACTCGCTCGTACTATGCGCTGGATAAGCAGTC
AAATGCGCCGTGGGCGTAATGATTATGAATCATTAATTGAAGATGCAAGTGATCAACTGCGTGCAGCAGACTTACAACCT
GATGAAATTTTCATTCGTGATGCAAGAACACTGCAAGAACCAACAGAAGAGACAACACAAGCCGTTATCCTAATGGCCGC
TTTTCTTGGCCAAGTACGTTTAATTGATAATCTCGTTGTTGAATTAACAACCGCTGCAAATGAGGAAGAAGAGGAAGAAG
AGGAAGAAGAAAAGTAA

Upstream 100 bases:

>100_bases
TGAAACTGGCGATATGCGTACCGCTGTAACCAAATATATTAAAGATGTTGAGCTAGGTGTATTCCCTGCAGCTGAACATA
CGTTTAACTAAGGAACCGTA

Downstream 100 bases:

>100_bases
TCCCTTCCTAATTATTGAATCACAAAAAAAGGGCAGATGCGATTATAGCGTCCGCCCTTTTTATTTCATTTATCTCCTCT
TAAATTGTAAGCGTGCGGGG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MEIFADILPLREQIKTWKREGKRIAFIPTMGNLHEGHLTLVRTAREHADIIVASIFVNPMQFNNVDDLTNYPRTIDEDIE
KLTSENVDMLFTPTPEVMYPDGLDKQTVVDVPVISTILEGASRPGHFKGVSTVVAKLFNIVQPDVACFGEKDFQQLALIR
QMVIDMAMDIDVVGVATVREMDGLAMSSRNNLLTLNERQRSPVLARTMRWISSQMRRGRNDYESLIEDASDQLRAADLQP
DEIFIRDARTLQEPTEETTQAVILMAAFLGQVRLIDNLVVELTTAANEEEEEEEEEEK

Sequences:

>Translated_298_residues
MEIFADILPLREQIKTWKREGKRIAFIPTMGNLHEGHLTLVRTAREHADIIVASIFVNPMQFNNVDDLTNYPRTIDEDIE
KLTSENVDMLFTPTPEVMYPDGLDKQTVVDVPVISTILEGASRPGHFKGVSTVVAKLFNIVQPDVACFGEKDFQQLALIR
QMVIDMAMDIDVVGVATVREMDGLAMSSRNNLLTLNERQRSPVLARTMRWISSQMRRGRNDYESLIEDASDQLRAADLQP
DEIFIRDARTLQEPTEETTQAVILMAAFLGQVRLIDNLVVELTTAANEEEEEEEEEEK
>Mature_298_residues
MEIFADILPLREQIKTWKREGKRIAFIPTMGNLHEGHLTLVRTAREHADIIVASIFVNPMQFNNVDDLTNYPRTIDEDIE
KLTSENVDMLFTPTPEVMYPDGLDKQTVVDVPVISTILEGASRPGHFKGVSTVVAKLFNIVQPDVACFGEKDFQQLALIR
QMVIDMAMDIDVVGVATVREMDGLAMSSRNNLLTLNERQRSPVLARTMRWISSQMRRGRNDYESLIEDASDQLRAADLQP
DEIFIRDARTLQEPTEETTQAVILMAAFLGQVRLIDNLVVELTTAANEEEEEEEEEEK

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=274, Percent_Identity=55.1094890510949, Blast_Score=320, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6322046, Length=313, Percent_Identity=37.6996805111821, Blast_Score=175, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_ALISL (B6ELE2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263953.1
- GeneID:   6988943
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2610
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 33790; Mature: 33790

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFADILPLREQIKTWKREGKRIAFIPTMGNLHEGHLTLVRTAREHADIIVASIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
QFNNVDDLTNYPRTIDEDIEKLTSENVDMLFTPTPEVMYPDGLDKQTVVDVPVISTILEG
HCCCCHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHC
ASRPGHFKGVSTVVAKLFNIVQPDVACFGEKDFQQLALIRQMVIDMAMDIDVVGVATVRE
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MDGLAMSSRNNLLTLNERQRSPVLARTMRWISSQMRRGRNDYESLIEDASDQLRAADLQP
HCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
DEIFIRDARTLQEPTEETTQAVILMAAFLGQVRLIDNLVVELTTAANEEEEEEEEEEK
CCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MEIFADILPLREQIKTWKREGKRIAFIPTMGNLHEGHLTLVRTAREHADIIVASIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
QFNNVDDLTNYPRTIDEDIEKLTSENVDMLFTPTPEVMYPDGLDKQTVVDVPVISTILEG
HCCCCHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHC
ASRPGHFKGVSTVVAKLFNIVQPDVACFGEKDFQQLALIRQMVIDMAMDIDVVGVATVRE
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MDGLAMSSRNNLLTLNERQRSPVLARTMRWISSQMRRGRNDYESLIEDASDQLRAADLQP
HCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
DEIFIRDARTLQEPTEETTQAVILMAAFLGQVRLIDNLVVELTTAANEEEEEEEEEEK
CCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA