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The map label for this gene is panB [H]

Identifier: 209696022

GI number: 209696022

Start: 2824935

End: 2825729

Strand: Direct

Name: panB [H]

Synonym: VSAL_I2609

Alternate gene names: 209696022

Gene position: 2824935-2825729 (Clockwise)

Preceding gene: 209696021

Following gene: 209696023

Centisome position: 84.96

GC content: 41.26

Gene sequence:

>795_bases
ATGAAAAAAATCTCTATTCATGATCTAATGAAATGGAAGCAAGATGGTCGTAAATTTGCAACAGTCACAGCTTATGACGC
TAGCTTCGCACAACTATTTGAACAGCAAGACATGCCTGTTTTATTAGTCGGTGATTCATTAGGTATGGTATTACAAGGTA
AAAGCGATACATTGCCTGTAACAACCGAAGAGATCGCTTATCATACGCGCTGTGTACGCGCTGGTAGCCCAAACAGCTTA
TTAATGGCTGATATGCCATTTATGAGTTACGCCACTCCAGAACAAGCCTGTCAGAACGCGGCTAAGTTAATGCAAGCTGG
CGCTAATATGGTAAAAATCGAAGGTGGTGAATGGATAGCGGAAACCATTAAACTCCTTGCAGAAAGAGCGGTACCTGTTT
GTGCTCACCTTGGGTTAACCCCTCAATCTGTCAACATTTTTGGTGGATTTAGAATTCAAGGTCGTGATGAAACTAAAGCG
AATCAAATGGTAAAAGATGCACTGACTCTTGAGAAAGCTGGCGCTCAAATTATCTTATTGGAATGTGTTCCCGCTTCGCT
TGCTGAACGTATAACGAAAGCTTGTACCGTTCCCGTGATTGGCATTGGTGCTGGTAACGTGACTGATGGTCAAATTTTAG
TAATGCATGACATGTTTGGTATCTCAGCAAACTACATGCCTAAATTTTCTAAGAATTTCTTAGCTGAAACTGGCGATATG
CGTACCGCTGTAACCAAATATATTAAAGATGTTGAGCTAGGTGTATTCCCTGCAGCTGAACATACGTTTAACTAA

Upstream 100 bases:

>100_bases
ACTTTACCTGATGGCTCAACCCTTTCTCAACTATTGACAACAATAGATAAGAATGGGCTAGCCGTTTGGGAAAAGTAATC
GCTTCTCGTAAGGATGTTTT

Downstream 100 bases:

>100_bases
GGAACCGTAATGGAAATTTTTGCCGATATTTTACCATTGCGCGAGCAAATAAAAACATGGAAACGAGAAGGAAAGCGTAT
TGCTTTTATTCCTACGATGG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase 1; KPHMT 1 [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKKISIHDLMKWKQDGRKFATVTAYDASFAQLFEQQDMPVLLVGDSLGMVLQGKSDTLPVTTEEIAYHTRCVRAGSPNSL
LMADMPFMSYATPEQACQNAAKLMQAGANMVKIEGGEWIAETIKLLAERAVPVCAHLGLTPQSVNIFGGFRIQGRDETKA
NQMVKDALTLEKAGAQIILLECVPASLAERITKACTVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
RTAVTKYIKDVELGVFPAAEHTFN

Sequences:

>Translated_264_residues
MKKISIHDLMKWKQDGRKFATVTAYDASFAQLFEQQDMPVLLVGDSLGMVLQGKSDTLPVTTEEIAYHTRCVRAGSPNSL
LMADMPFMSYATPEQACQNAAKLMQAGANMVKIEGGEWIAETIKLLAERAVPVCAHLGLTPQSVNIFGGFRIQGRDETKA
NQMVKDALTLEKAGAQIILLECVPASLAERITKACTVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
RTAVTKYIKDVELGVFPAAEHTFN
>Mature_264_residues
MKKISIHDLMKWKQDGRKFATVTAYDASFAQLFEQQDMPVLLVGDSLGMVLQGKSDTLPVTTEEIAYHTRCVRAGSPNSL
LMADMPFMSYATPEQACQNAAKLMQAGANMVKIEGGEWIAETIKLLAERAVPVCAHLGLTPQSVNIFGGFRIQGRDETKA
NQMVKDALTLEKAGAQIILLECVPASLAERITKACTVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
RTAVTKYIKDVELGVFPAAEHTFN

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=264, Percent_Identity=64.7727272727273, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319653, Length=273, Percent_Identity=34.7985347985348, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28721; Mature: 28721

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISIHDLMKWKQDGRKFATVTAYDASFAQLFEQQDMPVLLVGDSLGMVLQGKSDTLPV
CCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCC
TTEEIAYHTRCVRAGSPNSLLMADMPFMSYATPEQACQNAAKLMQAGANMVKIEGGEWIA
CHHHHHHHHHHEECCCCCCEEEECCCCHHCCCHHHHHHHHHHHHHCCCCEEEEECCCHHH
ETIKLLAERAVPVCAHLGLTPQSVNIFGGFRIQGRDETKANQMVKDALTLEKAGAQIILL
HHHHHHHHHCCHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEE
ECVPASLAERITKACTVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
EECCHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCH
RTAVTKYIKDVELGVFPAAEHTFN
HHHHHHHHHHHHCCEECCCCCCCC
>Mature Secondary Structure
MKKISIHDLMKWKQDGRKFATVTAYDASFAQLFEQQDMPVLLVGDSLGMVLQGKSDTLPV
CCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCC
TTEEIAYHTRCVRAGSPNSLLMADMPFMSYATPEQACQNAAKLMQAGANMVKIEGGEWIA
CHHHHHHHHHHEECCCCCCEEEECCCCHHCCCHHHHHHHHHHHHHCCCCEEEEECCCHHH
ETIKLLAERAVPVCAHLGLTPQSVNIFGGFRIQGRDETKANQMVKDALTLEKAGAQIILL
HHHHHHHHHCCHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEE
ECVPASLAERITKACTVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
EECCHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCH
RTAVTKYIKDVELGVFPAAEHTFN
HHHHHHHHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA