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The map label for this gene is tmk

Identifier: 209695681

GI number: 209695681

Start: 2415595

End: 2416227

Strand: Direct

Name: tmk

Synonym: VSAL_I2245

Alternate gene names: 209695681

Gene position: 2415595-2416227 (Clockwise)

Preceding gene: 209695680

Following gene: 209695682

Centisome position: 72.65

GC content: 42.65

Gene sequence:

>633_bases
ATGTCTAAATTTATTGTTATTGAAGGCCTTGAAGGCGCGGGTAAAAGCACCGCAATTAAGAACGTATTAGCAACACTGGC
TAAGCATGGAATTACAGCACCAGTGACGACAAGAGAGCCCGGTGGAACGCCGTTAGCCGAAAAAATGCGCGAACTAGTAA
AGCAAGGACATCCTGATGAGCCATTAACGGACATGGCCGAGTTATTACTATTGTATGCAGCACGAGCTCAGTTAGTTGGT
AATGTTATTAAACCAGCTTTAGCCGCAGGTAATTGGGTGGTTGGTGATCGTCATGATCTGTCATCTCAGGCTTATCAAGG
CGGTGGTCGTGGTTTTGACCGTGAGTTAATGGCGACCATGAAAAGAACAGTACTTGGTGATTTTACACCAGACTTAACTA
TCTATATGGATATTGATCCGAAGTTAGGGTTACAGCGTGCTTCTGCTCGTGGTGAGCTAGATAGAATCGAACAAATGAAA
CTGGATTTCTTTGAACGCAGTCGTGAACGTTATTTAGAATTTGCTAATAATGACGAAAGTATTATAACCATTGATGCAGG
ACAAGACTTAGATACGGTAACAGCATCGATTATTGCCGCTTTAGAAATATGGTTAGCGACGAATGGCAACTAA

Upstream 100 bases:

>100_bases
ATTTTGTTGCGGATGGAACGGGTGGTCATAAATTCACTAAATCATTAGTTGAGCATAACAAAGCAGTTAGAGCTTACTTA
AGAACCTTAAGAAATTAATT

Downstream 100 bases:

>100_bases
ACTCTATCCTTGGCAGAAAGAGGTTTGGTCGCAATGGCAACAATTGATTGAAAAGGATCGATTGCCACACGCCATTTTAT
GCGCTATGCCTGATGGCGTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITAPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVG
NVIKPALAAGNWVVGDRHDLSSQAYQGGGRGFDRELMATMKRTVLGDFTPDLTIYMDIDPKLGLQRASARGELDRIEQMK
LDFFERSRERYLEFANNDESIITIDAGQDLDTVTASIIAALEIWLATNGN

Sequences:

>Translated_210_residues
MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITAPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVG
NVIKPALAAGNWVVGDRHDLSSQAYQGGGRGFDRELMATMKRTVLGDFTPDLTIYMDIDPKLGLQRASARGELDRIEQMK
LDFFERSRERYLEFANNDESIITIDAGQDLDTVTASIIAALEIWLATNGN
>Mature_209_residues
SKFIVIEGLEGAGKSTAIKNVLATLAKHGITAPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVGN
VIKPALAAGNWVVGDRHDLSSQAYQGGGRGFDRELMATMKRTVLGDFTPDLTIYMDIDPKLGLQRASARGELDRIEQMKL
DFFERSRERYLEFANNDESIITIDAGQDLDTVTASIIAALEIWLATNGN

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=61.1650485436893, Blast_Score=248, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ALISL (B6EJ04)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263610.1
- GeneID:   6987670
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2245
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22927; Mature: 22796

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITAPVTTREPGGTPLAEKMRELVKQGHPDE
CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PLTDMAELLLLYAARAQLVGNVIKPALAAGNWVVGDRHDLSSQAYQGGGRGFDRELMATM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCCHHHHHHHH
KRTVLGDFTPDLTIYMDIDPKLGLQRASARGELDRIEQMKLDFFERSRERYLEFANNDES
HHHHHCCCCCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IITIDAGQDLDTVTASIIAALEIWLATNGN
EEEEECCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKFIVIEGLEGAGKSTAIKNVLATLAKHGITAPVTTREPGGTPLAEKMRELVKQGHPDE
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PLTDMAELLLLYAARAQLVGNVIKPALAAGNWVVGDRHDLSSQAYQGGGRGFDRELMATM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCCHHHHHHHH
KRTVLGDFTPDLTIYMDIDPKLGLQRASARGELDRIEQMKLDFFERSRERYLEFANNDES
HHHHHCCCCCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IITIDAGQDLDTVTASIIAALEIWLATNGN
EEEEECCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA