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The map label for this gene is fabF [H]

Identifier: 209695678

GI number: 209695678

Start: 2412442

End: 2413683

Strand: Direct

Name: fabF [H]

Synonym: VSAL_I2242

Alternate gene names: 209695678

Gene position: 2412442-2413683 (Clockwise)

Preceding gene: 209695677

Following gene: 209695679

Centisome position: 72.55

GC content: 44.36

Gene sequence:

>1242_bases
GTGTCCAAACGTCGTGTAGTAGTTACAGGCATGGGTATGCTAACACCGGTGGGTAACACTGTTGAAGCAGCCTGGAAAGC
GCTGTTAGCAGGCCAAAGTGGTATCGTTAATATCGAGCACTTTGATACCACTGAGTTTACGACTCGTTTTGCAGGTCTCG
TTAAAGACTTTAATGCTGAAGAGTACATGTCTAAGAAAGACGCTCGTAAAATGGATTTATTCATCCAATACGGTGTGGCT
GCTGGCATTCAGGCATTAGATGACTCGGGTTTTAAAGTTACTGAAGAAAATGCACACCGCATTGGTGCTGCTATTGGTTC
AGGTATTGGTGGTCTTGGCTTAATTGAAGCCGGTCACAAAGCCTTTACTGCAAAAGGTCCTCGTAAGATCAGCCCGTTTT
TCGTGCCTTCAACTATCGTAAATATGATTTCTGGTCATATGTCGATCATGCGCGGTCTACGTGGTCCTAATATCGCAATT
TCAACGGCTTGTACGACAGGTCTTCATAATATCGGTCATGCTGCACGTATGATCGCTTATGGTGATGCTGACGCAATGCT
AGCGGGTGGTGCAGAAAAAGCATCAACAGAGCTAGGTATGGGCGGTTTCGGTGCAGCTAAAGCACTGTCTACAAATAATG
AGAATCCACAAGCGGCTTCACGCCCATGGGATAAGAACCGTGATGGTTTTGTTCTAGGTGATGGCGCAGGCATGATGGTT
CTTGAAGAGTATGAACACGCAAAAGCGCGTGGTGCTAAAATCTACGCTGAATTAGTCGGTTTTGGTATGAGCGGCGATGC
TTACCATATGACTTCTCCTACTCCAGATGGTTCTGGTGGTGCGTTAGCTATGGAAGCGGCAATGCGTGATGCAAATGTAA
CGGGTGAACAAATCGGTTATGTTAACGCGCATGGTACATCAACACCTGCGGGTGATGTTGCTGAAATCAAAGGCATCAAA
CGTGCTTTAGGTGAAGAAGGTTCTAAGAAAGTATTAGTGTCATCAACAAAATCAATGACAGGTCACCTATTAGGTGCTGC
GGGTTCTGTTGAAGCGATTATTACGGTTATGTCTTTGATTGATCAAATAGCGCCACCAACGATTAATCTTGATGATCCTG
AAGAAGGTTTAGACATTGATCTTGTTCCGCATACTGCTCGTAAAGTTGAGATGGAATACGCTATTTGTAATTCATTCGGC
TTTGGTGGTACAAACGGCACATTAATATTTAAGAAAATGTAA

Upstream 100 bases:

>100_bases
CACAGTAAGAAATACCCTCCAGGCGGTCACTCTTGACCGCCTGAGTTTTTTTATACGCTACAATCCCTATCTAATTCAAT
TAATTCCGGAGAAATATATC

Downstream 100 bases:

>100_bases
TAACTTGTTTGTGAGGCTTAATTAGTTTCACTCAGTTAGTTATACTAGAAAGCGGCTTGATATTATATCAAGCCGCTTTT
TTCTGTTTGGAGTACTGTAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSKRRVVVTGMGMLTPVGNTVEAAWKALLAGQSGIVNIEHFDTTEFTTRFAGLVKDFNAEEYMSKKDARKMDLFIQYGVA
AGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGHKAFTAKGPRKISPFFVPSTIVNMISGHMSIMRGLRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQAASRPWDKNRDGFVLGDGAGMMV
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDANVTGEQIGYVNAHGTSTPAGDVAEIKGIK
RALGEEGSKKVLVSSTKSMTGHLLGAAGSVEAIITVMSLIDQIAPPTINLDDPEEGLDIDLVPHTARKVEMEYAICNSFG
FGGTNGTLIFKKM

Sequences:

>Translated_413_residues
MSKRRVVVTGMGMLTPVGNTVEAAWKALLAGQSGIVNIEHFDTTEFTTRFAGLVKDFNAEEYMSKKDARKMDLFIQYGVA
AGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGHKAFTAKGPRKISPFFVPSTIVNMISGHMSIMRGLRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQAASRPWDKNRDGFVLGDGAGMMV
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDANVTGEQIGYVNAHGTSTPAGDVAEIKGIK
RALGEEGSKKVLVSSTKSMTGHLLGAAGSVEAIITVMSLIDQIAPPTINLDDPEEGLDIDLVPHTARKVEMEYAICNSFG
FGGTNGTLIFKKM
>Mature_412_residues
SKRRVVVTGMGMLTPVGNTVEAAWKALLAGQSGIVNIEHFDTTEFTTRFAGLVKDFNAEEYMSKKDARKMDLFIQYGVAA
GIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGHKAFTAKGPRKISPFFVPSTIVNMISGHMSIMRGLRGPNIAIS
TACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQAASRPWDKNRDGFVLGDGAGMMVL
EEYEHAKARGAKIYAELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDANVTGEQIGYVNAHGTSTPAGDVAEIKGIKR
ALGEEGSKKVLVSSTKSMTGHLLGAAGSVEAIITVMSLIDQIAPPTINLDDPEEGLDIDLVPHTARKVEMEYAICNSFGF
GGTNGTLIFKKM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=45.9134615384615, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=47.5903614457831, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI41872631, Length=422, Percent_Identity=23.9336492890995, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=74.1545893719807, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=36.7788461538462, Blast_Score=234, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=37.6811594202899, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=43.2330827067669, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI212642053, Length=423, Percent_Identity=23.1678486997636, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=23.7410071942446, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=38.3747178329571, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=42.4882629107981, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI19920632, Length=425, Percent_Identity=21.6470588235294, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221330659, Length=425, Percent_Identity=21.6470588235294, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24581345, Length=372, Percent_Identity=22.5806451612903, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43193; Mature: 43062

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVVTGMGMLTPVGNTVEAAWKALLAGQSGIVNIEHFDTTEFTTRFAGLVKDFNAE
CCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
EYMSKKDARKMDLFIQYGVAAGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGHK
HHHHHHCCHHHHHHEEHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCHHHHCCCC
AFTAKGPRKISPFFVPSTIVNMISGHMSIMRGLRGPNIAISTACTTGLHNIGHAARMIAY
EEECCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHEEEE
GDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQAASRPWDKNRDGFVLGDGAGMMV
CCCCCEEECCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDANVTGEQIGY
EHHHHHHHHCCHHEEEHHHCCCCCCCEEEECCCCCCCCCCEEEHHHHHHCCCCCHHHEEE
VNAHGTSTPAGDVAEIKGIKRALGEEGSKKVLVSSTKSMTGHLLGAAGSVEAIITVMSLI
EECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHH
DQIAPPTINLDDPEEGLDIDLVPHTARKVEMEYAICNSFGFGGTNGTLIFKKM
HHHCCCCCCCCCCCCCCEEEECCCCCHHEEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SKRRVVVTGMGMLTPVGNTVEAAWKALLAGQSGIVNIEHFDTTEFTTRFAGLVKDFNAE
CCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
EYMSKKDARKMDLFIQYGVAAGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGHK
HHHHHHCCHHHHHHEEHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCHHHHCCCC
AFTAKGPRKISPFFVPSTIVNMISGHMSIMRGLRGPNIAISTACTTGLHNIGHAARMIAY
EEECCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHEEEE
GDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQAASRPWDKNRDGFVLGDGAGMMV
CCCCCEEECCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDANVTGEQIGY
EHHHHHHHHCCHHEEEHHHCCCCCCCEEEECCCCCCCCCCEEEHHHHHHCCCCCHHHEEE
VNAHGTSTPAGDVAEIKGIKRALGEEGSKKVLVSSTKSMTGHLLGAAGSVEAIITVMSLI
EECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHH
DQIAPPTINLDDPEEGLDIDLVPHTARKVEMEYAICNSFGFGGTNGTLIFKKM
HHHCCCCCCCCCCCCCCEEEECCCCCHHEEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]