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The map label for this gene is clpA [H]

Identifier: 209695651

GI number: 209695651

Start: 2380907

End: 2383159

Strand: Direct

Name: clpA [H]

Synonym: VSAL_I2214

Alternate gene names: 209695651

Gene position: 2380907-2383159 (Clockwise)

Preceding gene: 209695650

Following gene: 209695655

Centisome position: 71.6

GC content: 39.24

Gene sequence:

>2253_bases
ATGCTAAATAAAGAATTAGAAGCGAGTTTAAACAGTGCGTTTGCTCGTGCAAGAGAAAAGCGTCATGAATTTATGACAGT
GGAGCATTTGTTATTTGCTCTATTAGAGAACCCATCTGCACACGAAGCTCTTATTGCTTGCCATACAGACCTGGATGCTC
TTTCGACAGAAATTGATGAATTCATAACACAAACAACTCCTCTTATTCCAGCTGACGATGATAGTCGTGAAACGCAGCCA
ACGTTAAGCTTTCAACGTGTTCTTCAACGAGCTGTTTTTCATGTTCAATCATCAGGTCGTAATGAAGTCACTGGCGCGAA
TGTTTTAGTCGCTATTTTTAGCGAGCAAGAATCTCATGCTGCTTATCTTCTTAAAAAGAATGATATTAGTCGACTCGATA
TTGTTAACTTTATTTCTCATGGTGCACCAGAAAATCGAGATGAGAATTCAGAACAATCAAATGTAGAAGCCGCTGTTGAA
GGCAATTCTGATGATCAATTAGAAAGCTTCGCAACTAACTTAAATCAAGTCGCTAAAAATGGCGGTATTGATCCGTTGAT
TGGTCGTGAGCAAGAAGTTGAACGAACAATTCAAGTTCTTTGTCGTCGACGTAAAAATAACCCATTACTAGTGGGTGAAG
CTGGAGTCGGAAAAACGGCGATAGCGGAAGGGTTAGCATGGAGAATTGTTGAAGAACAAGTTCCCGATGTGATTAAAGAT
TGTATTATTTATTCTCTTGATATTGGTTCTCTATTAGCGGGTACTAAATATCGTGGTGATTTTGAAAAACGATTTAAAGC
CATTTTAAAACAGCTTGAAAAAGAAGAACATGCGATTTTATTCATTGATGAAATCCATACCATTATTGGCGCTGGTGCCG
CTTCTGGTGGGCAAGTTGATGCGGCTAATTTAATTAAGCCATTACTAAGCAGCGGTAAGTTACGTTGTATTGGTTCTACA
ACTTATCAAGAACACAGTACTATTTTTGAAAAAGAACGAGCGCTTGCTCGTCGATTCCAAAAAATTGATATTTTAGAACC
ATCAATAGATGATACAACTAAAATATTAATGGGTCTGAAAAGTAAATATGAAGAACACCACGAGGTTCGTTATACCAATA
AAGCACTCCGTGCTGCGGTAGAACTGTCAGCGAAATACATTAATGAGCGTCACTTGCCAGATAAGGCGATTGATGTGATT
GATGAAGCTGGTGCCCGTTGTCGTTTGACTCCAATTAGCCGTCGCAAAAAAACCATCAATGTTGCTGATATAGAATCGAT
GGTTGCTAAAATGGCTCGTATTCCAGAAAAATCAGTATCATCAAGCGATAAAGATGTACTGAAAAAACTGGATGCTAAAC
TTAAAATGTTAGTGTTTGGGCAAGATCAAGGTATCGATGTTTTATGTGAAGCCATTAAATTGAGCCGTGCTGGACTGGGT
GCAGATAATAAACCTGTTGGTTCTTTCTTGTTTGCGGGTCCGACAGGGGTTGGTAAAACTGAAGTAACGGTACAATTAGC
AAAAGCATTGGGCATAGAATTATTACGTTTTGATATGTCTGAGTACGGTGAGCGTCATACTGTTAGTCGCTTGATCGGTG
CTCCTCCTGGTTACGTTGGTTATGAGCAGGGAGGTCTATTAACCGACGCGGTTATTAAGCATCCTCATTCTGTCGTATTA
CTTGATGAGCTTGAAAAAGCACACCCTGACGTATTTAATTTGCTACTGCAAGTTATGGATAATGGGACATTAACGGATAA
CAATGGCCGTAAAGCTGATTTCCGCAATGTTATTTTTGTAATGACAACCAATGCTGGTGTCCATGACACGGTCAAAAAAT
CTATTGGTTTAATCCAACAAGATCACAGTACCGATGCGATGGCTGCGATTAAAAAAGTATTTACGCCAGAATTTAGAAAC
CGTCTGGATAATATTATTTGGTTTGAGCACTTAGGCAAAGACGTGATCGGGCAAGTTGTTGATAAGTTCATTGTTGAATT
ACAAGCACAATTAGACGCTCGTGGTGTATCAATGGAAGTATCGCAAGATGTCAAAGAGTGGTTAGCTAATAAAGGATACG
ATAAAGCGATGGGCGCACGTCCAATGGCTCGTGTTATTCAAGAAAACTTGAAAAAACCAATGGCAAATGAGCTATTATTT
GGTGAGTTAGTTAATGGTGGCACCGTTCGAGTTAAATTAACGAAAGGTGAATTGGACTTTGAGTTTACGAGTGAAGCTGA
AGTTGTCCATTAA

Upstream 100 bases:

>100_bases
AAACATTTATTCGCGTGATAATGAGCACCCACTACTGTGTACAATGGAGCAAGCTTAAGTTTGTTCGTTACACCATCATT
TGGTGTTTTGGGAGGTTCCT

Downstream 100 bases:

>100_bases
ATATCATTTTATAATGTTATAAATATAAAAAACCCAGTCTGTTGACTGGGTTTTTTTATATTGTTTAATACTACCCAGTG
TAAATATGTTTACTTTGGGT

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MLNKELEASLNSAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALSTEIDEFITQTTPLIPADDDSRETQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGAPENRDENSEQSNVEAAVE
GNSDDQLESFATNLNQVAKNGGIDPLIGREQEVERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CIIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLRCIGST
TYQEHSTIFEKERALARRFQKIDILEPSIDDTTKILMGLKSKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVI
DEAGARCRLTPISRRKKTINVADIESMVAKMARIPEKSVSSSDKDVLKKLDAKLKMLVFGQDQGIDVLCEAIKLSRAGLG
ADNKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGERHTVSRLIGAPPGYVGYEQGGLLTDAVIKHPHSVVL
LDELEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIFVMTTNAGVHDTVKKSIGLIQQDHSTDAMAAIKKVFTPEFRN
RLDNIIWFEHLGKDVIGQVVDKFIVELQAQLDARGVSMEVSQDVKEWLANKGYDKAMGARPMARVIQENLKKPMANELLF
GELVNGGTVRVKLTKGELDFEFTSEAEVVH

Sequences:

>Translated_750_residues
MLNKELEASLNSAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALSTEIDEFITQTTPLIPADDDSRETQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGAPENRDENSEQSNVEAAVE
GNSDDQLESFATNLNQVAKNGGIDPLIGREQEVERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CIIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLRCIGST
TYQEHSTIFEKERALARRFQKIDILEPSIDDTTKILMGLKSKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVI
DEAGARCRLTPISRRKKTINVADIESMVAKMARIPEKSVSSSDKDVLKKLDAKLKMLVFGQDQGIDVLCEAIKLSRAGLG
ADNKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGERHTVSRLIGAPPGYVGYEQGGLLTDAVIKHPHSVVL
LDELEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIFVMTTNAGVHDTVKKSIGLIQQDHSTDAMAAIKKVFTPEFRN
RLDNIIWFEHLGKDVIGQVVDKFIVELQAQLDARGVSMEVSQDVKEWLANKGYDKAMGARPMARVIQENLKKPMANELLF
GELVNGGTVRVKLTKGELDFEFTSEAEVVH
>Mature_750_residues
MLNKELEASLNSAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALSTEIDEFITQTTPLIPADDDSRETQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGAPENRDENSEQSNVEAAVE
GNSDDQLESFATNLNQVAKNGGIDPLIGREQEVERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CIIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLRCIGST
TYQEHSTIFEKERALARRFQKIDILEPSIDDTTKILMGLKSKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVI
DEAGARCRLTPISRRKKTINVADIESMVAKMARIPEKSVSSSDKDVLKKLDAKLKMLVFGQDQGIDVLCEAIKLSRAGLG
ADNKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGERHTVSRLIGAPPGYVGYEQGGLLTDAVIKHPHSVVL
LDELEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIFVMTTNAGVHDTVKKSIGLIQQDHSTDAMAAIKKVFTPEFRN
RLDNIIWFEHLGKDVIGQVVDKFIVELQAQLDARGVSMEVSQDVKEWLANKGYDKAMGARPMARVIQENLKKPMANELLF
GELVNGGTVRVKLTKGELDFEFTSEAEVVH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=315, Percent_Identity=30.7936507936508, Blast_Score=147, Evalue=5e-35,
Organism=Escherichia coli, GI1787109, Length=760, Percent_Identity=76.7105263157895, Blast_Score=1198, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=324, Percent_Identity=42.5925925925926, Blast_Score=286, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=321, Percent_Identity=47.0404984423676, Blast_Score=293, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6323002, Length=392, Percent_Identity=36.2244897959184, Blast_Score=245, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83081; Mature: 83081

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKELEASLNSAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALSTEIDE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHHHH
FITQTTPLIPADDDSRETQPTLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESHA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
AYLLKKNDISRLDIVNFISHGAPENRDENSEQSNVEAAVEGNSDDQLESFATNLNQVAKN
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHC
GGIDPLIGREQEVERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
CIIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAILFIDEIHTIIGAGAASGGQVD
HHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCC
AANLIKPLLSSGKLRCIGSTTYQEHSTIFEKERALARRFQKIDILEPSIDDTTKILMGLK
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARCRLTPISRRKKTIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHCCCCCC
VADIESMVAKMARIPEKSVSSSDKDVLKKLDAKLKMLVFGQDQGIDVLCEAIKLSRAGLG
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCC
ADNKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGERHTVSRLIGAPPGYVG
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
YEQGGLLTDAVIKHPHSVVLLDELEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIFV
CCCCCCHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEEE
MTTNAGVHDTVKKSIGLIQQDHSTDAMAAIKKVFTPEFRNRLDNIIWFEHLGKDVIGQVV
EECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHH
DKFIVELQAQLDARGVSMEVSQDVKEWLANKGYDKAMGARPMARVIQENLKKPMANELLF
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCCHHHHHHHH
GELVNGGTVRVKLTKGELDFEFTSEAEVVH
HHHCCCCEEEEEEECCCCCEEECCCCCCCC
>Mature Secondary Structure
MLNKELEASLNSAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALSTEIDE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHHHH
FITQTTPLIPADDDSRETQPTLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESHA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
AYLLKKNDISRLDIVNFISHGAPENRDENSEQSNVEAAVEGNSDDQLESFATNLNQVAKN
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHC
GGIDPLIGREQEVERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
CIIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAILFIDEIHTIIGAGAASGGQVD
HHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCC
AANLIKPLLSSGKLRCIGSTTYQEHSTIFEKERALARRFQKIDILEPSIDDTTKILMGLK
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARCRLTPISRRKKTIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHCCCCCC
VADIESMVAKMARIPEKSVSSSDKDVLKKLDAKLKMLVFGQDQGIDVLCEAIKLSRAGLG
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCC
ADNKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGERHTVSRLIGAPPGYVG
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
YEQGGLLTDAVIKHPHSVVLLDELEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVIFV
CCCCCCHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEEE
MTTNAGVHDTVKKSIGLIQQDHSTDAMAAIKKVFTPEFRNRLDNIIWFEHLGKDVIGQVV
EECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHH
DKFIVELQAQLDARGVSMEVSQDVKEWLANKGYDKAMGARPMARVIQENLKKPMANELLF
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCCHHHHHHHH
GELVNGGTVRVKLTKGELDFEFTSEAEVVH
HHHCCCCEEEEEEECCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]