Click here to switch to the map view.

The map label for this gene is varA [H]

Identifier: 209695582

GI number: 209695582

Start: 2296671

End: 2297315

Strand: Reverse

Name: varA [H]

Synonym: VSAL_I2141

Alternate gene names: 209695582

Gene position: 2297315-2296671 (Counterclockwise)

Preceding gene: 209695583

Following gene: 209695581

Centisome position: 69.09

GC content: 40.31

Gene sequence:

>645_bases
GTGATTAAAGTATTCCTTGTAGATGATCATGAGCTGGTTCGCACAGGGATTCGACGTATTCTTGAAGACGTCCGTGGAAT
TAAAGTAGTAGGGGAAGCTGACAGCGGTGAAGATGCCGTTAAATGGTGTCGAACAGAGCAGGCTGATATTGTTCTGATGG
ATATGAACATGCCTGGTATTGGTGGCTTAGAAGCCACGAAAAAGATTTTACGATTTAACCCAGATATGAAAGTTATAGTA
TTAACTATTCATACTGAGAATCCATTCCCAACGAAGGTGATGCAAGCGGGAGCTGCAGGCTATCTAACCAAAGGTGCGGG
ACCGGATGAAATGGTGAATGCTATTCGTATGGTACAAAGTGGCCAGCGTTACTTATCACCAGAAATTGCTCAACAAATGG
CGTTAAGTCAATTTACGCCTGATTCTGAAAATCCTTTTAAAGAACTTTCAGAGCGTGAGTTACAGATAATGATCATGATT
ACTAAAGGCGAAAAAGTGACGGATATTTCCGAACAACTTAATTTAAGCCCTAAAACTGTGAACAGTTATCGTTATCGATT
ATTCAGTAAATTAGACATTAGTGGAGATGTTGAATTAACGCATTTAGCTATTCGTCATGGCATATTAGATGCTGAGACGC
TGTAG

Upstream 100 bases:

>100_bases
ACGCATAATCAATGCGCGCATTACTTTTTATTTAAGGTAAAATAGGACATTGAGATAAGCCTCAGCCGAGGTGGCTGTAG
ATTAATTCGGAGTGTCAGTT

Downstream 100 bases:

>100_bases
TGCCTCCTTTTGATTCAAAAGCTTTTCTACTATCAGTTACCCATCAGCCCGGCGTTTATCGAATGTATAACGCCGAAGCT
GAGGTTATTTACGTCGGTAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIKVFLVDDHELVRTGIRRILEDVRGIKVVGEADSGEDAVKWCRTEQADIVLMDMNMPGIGGLEATKKILRFNPDMKVIV
LTIHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRMVQSGQRYLSPEIAQQMALSQFTPDSENPFKELSERELQIMIMI
TKGEKVTDISEQLNLSPKTVNSYRYRLFSKLDISGDVELTHLAIRHGILDAETL

Sequences:

>Translated_214_residues
MIKVFLVDDHELVRTGIRRILEDVRGIKVVGEADSGEDAVKWCRTEQADIVLMDMNMPGIGGLEATKKILRFNPDMKVIV
LTIHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRMVQSGQRYLSPEIAQQMALSQFTPDSENPFKELSERELQIMIMI
TKGEKVTDISEQLNLSPKTVNSYRYRLFSKLDISGDVELTHLAIRHGILDAETL
>Mature_214_residues
MIKVFLVDDHELVRTGIRRILEDVRGIKVVGEADSGEDAVKWCRTEQADIVLMDMNMPGIGGLEATKKILRFNPDMKVIV
LTIHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRMVQSGQRYLSPEIAQQMALSQFTPDSENPFKELSERELQIMIMI
TKGEKVTDISEQLNLSPKTVNSYRYRLFSKLDISGDVELTHLAIRHGILDAETL

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=75.8139534883721, Blast_Score=349, Evalue=1e-97,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=35, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=31.7073170731707, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1786747, Length=200, Percent_Identity=26.5, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=27.0935960591133, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23946; Mature: 23946

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVFLVDDHELVRTGIRRILEDVRGIKVVGEADSGEDAVKWCRTEQADIVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCC
GGLEATKKILRFNPDMKVIVLTIHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRMVQS
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHC
GQRYLSPEIAQQMALSQFTPDSENPFKELSERELQIMIMITKGEKVTDISEQLNLSPKTV
CCHHCCHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEEECCCCEECHHHHHCCCCCHH
NSYRYRLFSKLDISGDVELTHLAIRHGILDAETL
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIKVFLVDDHELVRTGIRRILEDVRGIKVVGEADSGEDAVKWCRTEQADIVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCC
GGLEATKKILRFNPDMKVIVLTIHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRMVQS
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHC
GQRYLSPEIAQQMALSQFTPDSENPFKELSERELQIMIMITKGEKVTDISEQLNLSPKTV
CCHHCCHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEEECCCCEECHHHHHCCCCCHH
NSYRYRLFSKLDISGDVELTHLAIRHGILDAETL
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]